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Abstract

, a non-tuberculous mycobacterium, was recently identified as causative agent of deep-seated infections in patients who had previously undergone open-chest cardiac surgery. Outbreak investigations suggested an aerosol-borne pathogen transmission originating from water contained in heater-cooler units (HCUs) used during cardiac surgery. Similar thermoregulatory devices are used for extracorporeal membrane oxygenation (ECMO) and might also be detectable in ECMO treatment settings. We performed a prospective microbiological study investigating the occurrence of in water from ECMO systems and in environmental samples, and a retrospective clinical review of possible ECMO-related mycobacterial infections among patients in a pneumological intensive care unit. We detected in 9 of 18 water samples from 10 different thermoregulatory ECMO devices; no mycobacteria were found in the nine room air samples and other environmental samples. Among 118 ECMO patients, 76 had bronchial specimens analysed for mycobacteria and was found in three individuals without signs of mycobacterial infection at the time of sampling. We conclude that can be detected in water samples from ECMO-associated thermoregulatory devices and might potentially pose patients at risk of infection. Further research is warranted to elucidate the clinical significance of in ECMO treatment settings.

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/content/10.2807/1560-7917.ES.2016.21.46.30398
2016-11-17
2024-11-05
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.46.30398
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Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Franziska+C.+Trudzinski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trudzinski Franziska C.</a>, <a href="/search?value1=Uwe+Schlotthauer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schlotthauer Uwe</a>, <a href="/search?value1=Annegret+Kamp&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kamp Annegret</a>, <a href="/search?value1=Kai+Hennemann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hennemann Kai</a>, <a href="/search?value1=Ralf+M.+Muellenbach&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muellenbach Ralf M.</a>, <a href="/search?value1=Udo+Reischl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reischl Udo</a>, <a href="/search?value1=Barbara+G%C3%A4rtner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gärtner Barbara</a>, <a href="/search?value1=Heinrike+Wilkens&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wilkens Heinrike</a>, <a href="/search?value1=Robert+Bals&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bals Robert</a>, <a href="/search?value1=Mathias+Herrmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Herrmann Mathias</a>, <a href="/search?value1=Philipp+M.+Lepper&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lepper Philipp M.</a>, <a href="/search?value1=S%C3%B6ren+L.+Becker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Becker Sören L.</a></span>. Clinical implications of Mycobacterium chimaera detection in thermoregulatory devices used for extracorporeal membrane oxygenation (ECMO), Germany, 2015 to 2016. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(46):pii=30398. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.46.30398" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.46.30398</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 07 Sept 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 19 Oct 2016 </span> </p>
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