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Abstract

Following the reported link between heater–cooler unit (HCU) colonisation with and endocarditis, mycobacterial sampling of all HCUs in use in Western Australia was initiated from August 2015, revealing colonisation in 10 of 15 HCUs. After was isolated from a pleural biopsy from a cardiothoracic patient who may have been exposed to a colonised HCU, a whole genome sequencing investigation was performed involving 65 specimens from 15 HCUs across five hospitals to assess if this infection was related to the HCU. Genetic relatedness was found between the 10 HCU isolates from four hospitals. However the isolate from the cardiothoracic patient was not genetically related to the HCU isolates from that hospital, nor to the other HCU isolates, indicating that the HCUs were not the source of the infection in this patient.

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/content/10.2807/1560-7917.ES.2016.21.46.30396
2016-11-17
2024-11-05
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2016.21.46.30396
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References

  1. Tortoli E, Rindi L, Garcia MJ, Chiaradonna P, Dei R, Garzelli C, et al. Proposal to elevate the genetic variant MAC-A, included in the Mycobacterium avium complex, to species rank as Mycobacterium chimaera sp. nov. Int J Syst Evol Microbiol. 2004;54(Pt 4):1277-85.  https://doi.org/10.1099/ijs.0.02777-0  PMID: 15280303 
  2. Boyle DP, Zembower TR, Reddy S, Qi C. Comparison of Clinical Features, Virulence, and Relapse among Mycobacterium avium Complex Species. Am J Respir Crit Care Med. 2015;191(11):1310-7.  https://doi.org/10.1164/rccm.201501-0067OC  PMID: 25835090 
  3. Cohen-Bacrie S, David M, Stremler N, Dubus JC, Rolain JM, Drancourt M. Mycobacterium chimaera pulmonary infection complicating cystic fibrosis: a case report. J Med Case Reports. 2011;5(1):473.  https://doi.org/10.1186/1752-1947-5-473  PMID: 21939536 
  4. Achermann Y, Rössle M, Hoffmann M, Deggim V, Kuster S, Zimmermann DR, et al. Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera. J Clin Microbiol. 2013;51(6):1769-73.  https://doi.org/10.1128/JCM.00435-13  PMID: 23536407 
  5. Götting T, Klassen S, Jonas D, Benk Ch, Serr A, Wagner D, et al. Heater-cooler units: contamination of crucial devices in cardiothoracic surgery. J Hosp Infect. 2016;93(3):223-8.  https://doi.org/10.1016/j.jhin.2016.02.006  PMID: 27101883 
  6. Haller S, Höller C, Jacobshagen A, Hamouda O, Abu Sin M, Monnet DL, et al. Contamination during production of heater-cooler units by Mycobacterium chimaera potential cause for invasive cardiovascular infections: results of an outbreak investigation in Germany, April 2015 to February 2016. Euro Surveill. 2016;21(17):30215.  https://doi.org/10.2807/1560-7917.ES.2016.21.17.30215  PMID: 27168588 
  7. Kohler P, Kuster SP, Bloemberg G, Schulthess B, Frank M, Tanner FC, et al. Healthcare-associated prosthetic heart valve, aortic vascular graft, and disseminated Mycobacterium chimaera infections subsequent to open heart surgery. Eur Heart J. 2015;36(40):2745-53.  https://doi.org/10.1093/eurheartj/ehv342  PMID: 26188001 
  8. Sax H, Bloemberg G, Hasse B, Sommerstein R, Kohler P, Achermann Y, et al. Prolonged Outbreak of Mycobacterium chimaera Infection After Open-Chest Heart Surgery. Clin Infect Dis. 2015;61(1):67-75.  https://doi.org/10.1093/cid/civ198  PMID: 25761866 
  9. Perkins KM, Lawsin A, Hasan NA, Strong M, Halpin AL, Rodger RR, et al. Notes from the Field: Mycobacterium chimaera Contamination of Heater-Cooler Devices Used in Cardiac Surgery - United States. MMWR Morb Mortal Wkly Rep. 2016;65(40):1117-8.  https://doi.org/10.15585/mmwr.mm6540a6  PMID: 27740609 
  10. Tan N, Sampath R, Abu Saleh OM, Tweet MS, Jevremovic D, Alniemi S, et al. Disseminated Mycobacterium chimaera Infection After Cardiothoracic Surgery. Open Forum Infect Dis. 2016;3(3):ofw131.  https://doi.org/10.1093/ofid/ofw131  PMID: 27703994 
  11. Sommerstein R, Rüegg C, Kohler P, Bloemberg G, Kuster SP, Sax H. Transmission of Mycobacterium chimaera from Heater-Cooler Units during Cardiac Surgery despite an Ultraclean Air Ventilation System. Emerg Infect Dis. 2016;22(6):1008-13.  https://doi.org/10.3201/eid2206.160045  PMID: 27070958 
  12. Taylor A, Jones D, Everts R, Cowen A, Wardle E, editors. Infection control in endoscopy. 3rd ed. Mulgrave: Gastroenterological Society of Australia; 2010. Available from: http://membes.gesa.org.au/membes/files/Clinical%20Guidelines%20and%20Updates/Infection_Control_in_Endoscopy_Guidelines_2014.pdf
  13. Public Health England (PHE). Protocol for environmental sampling, processing and culturing of water and air samples for the isolation of slow-growing mycobacteria. Standard operating procedure. London: PHE; 2015. Available from: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/540325/Air_water_environmental_sampling_SOP_V2.pdf
  14. European Centre for Disease Prevention and Control (ECDC). EU protocol for case detection, laboratory diagnosis and environmental testing of Mycobacterium chimaera infections potentially associated with heater-cooler units: case definition and environmental testing methodology. Stockholm: ECDC; 2015. Available from: http://ecdc.europa.eu/en/publications/Publications/EU-protocol-for-M-chimaera.pdf
  15. Mac Aogáin M, Roycroft E, Raftery P, Mok S, Fitzgibbon M, Rogers TR. Draft Genome Sequences of Three Mycobacterium chimaera Respiratory Isolates. Genome Announc. 2015;3(6):e01409-15.  https://doi.org/10.1128/genomeA.01409-15  PMID: 26634757 
  16. Seemann T, Goncalves da Silva A, Bulach DM, Schultz MB, Kwong JC, Howden BP. Nullarbor. San Francisco; Github. [Accessed: 03 Jun 2016]. Available from: https://github.com/tseemann/nullarbor
  17. Kumar S, Stecher G, Tamura K. MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets. Mol Biol Evol. 2016;33(7):1870-4.  https://doi.org/10.1093/molbev/msw054  PMID: 27004904 
Mycobacterium chimaera colonisation of heater–cooler units (HCU) in Western Australia, 2015: investigation of possible iatrogenic infection using whole genome sequencing
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=James+Owen+Robinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robinson James Owen</a>, <a href="/search?value1=Geoffrey+Wallace+Coombs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Coombs Geoffrey Wallace</a>, <a href="/search?value1=David+John+Speers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Speers David John</a>, <a href="/search?value1=Terillee+Keehner&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Keehner Terillee</a>, <a href="/search?value1=Anthony+David+Keil&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Keil Anthony David</a>, <a href="/search?value1=Victoria+D%E2%80%99Abrera&option1=author&noRedirect=true" class="nonDisambigAuthorLink">D’Abrera Victoria</a>, <a href="/search?value1=Peter+Boan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Boan Peter</a>, <a href="/search?value1=Stanley+Pang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pang Stanley</a></span>. Mycobacterium chimaera colonisation of heater–cooler units (HCU) in Western Australia, 2015: investigation of possible iatrogenic infection using whole genome sequencing. <a href="/content/ecdc">Euro Surveill.</a> 2016;21(46):pii=30396. <a href="https://doi.org/10.2807/1560-7917.ES.2016.21.46.30396" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2016.21.46.30396</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 06 Sept 2016;&nbsp;&nbsp; <span class="generated">Accepted</span>: 04 Oct 2016 </span> </p>
/content/10.2807/1560-7917.ES.2016.21.46.30396
/content/10.2807/1560-7917.ES.2016.21.46.30396
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