1887
  1. Home
  2. Eurosurveillance
  3. Volume 20, Issue 40, 08/Oct/2015
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

The Magazine Wharf area, Freetown, Sierra Leone was a focus of ongoing Ebola virus transmission from late June 2015. Viral genomes linked to this area contain a series of 13 T to C substitutions in a 150 base pair intergenic region downstream of viral protein 40 open reading frame, similar to the Ebolavirus/H.sapiens-wt/SLE/2014/Makona-J0169 strain (J0169) detected in the same town in November 2014. This suggests that recently circulating viruses from Freetown descend from a J0169-like virus.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2015.20.40.30035
2015-10-08
2024-11-14
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2015.20.40.30035
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/20/40/eurosurv-20-30035-2.html?itemId=/content/10.2807/1560-7917.ES.2015.20.40.30035&mimeType=html&fmt=ahah

References

  1. Baize S, Pannetier D, Oestereich L, Rieger T, Koivogui L, Magassouba N, et al. Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371(15):1418-25.  https://doi.org/10.1056/NEJMoa1404505  PMID: 24738640 
  2. Carroll MW, Matthews DA, Hiscox JA, Elmore MJ, Pollakis G, Rambaut A, et al. Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa. Nature. 2015;524(7563):97-101.  https://doi.org/10.1038/nature14594  PMID: 26083749 
  3. Gire SK, Goba A, Andersen KG, Sealfon RS, Park DJ, Kanneh L, et al. Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak. Science. 2014;345(6202):1369-72.  https://doi.org/10.1126/science.1259657  PMID: 25214632 
  4. Kugelman JR, Wiley MR, Mate S, Ladner JT, Beitzel B, Fakoli L, et al. US Army Medical Research Institute of Infectious DiseasesNational Institutes of HealthIntegrated Research Facility–Frederick Ebola Response Team 2014–2015. Monitoring of Ebola Virus Makona Evolution through Establishment of Advanced Genomic Capability in Liberia. Emerg Infect Dis. 2015;21(7):1135-43.  https://doi.org/10.3201/eid2107.150522  PMID: 26079255 
  5. Park DJ, Dudas G, Wohl S, Goba A, Whitmer SL, Andersen KG, et al. Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone. Cell. 2015;161(7):1516-26.  https://doi.org/10.1016/j.cell.2015.06.007  PMID: 26091036 
  6. Simon-Loriere E, Faye O, Faye O, Koivogui L, Magassouba N, Keita S, et al. Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic. Nature. 2015;524(7563):102-4.  https://doi.org/10.1038/nature14612  PMID: 26106863 
  7. Tong YG, Shi WF, Liu D, Qian J, Liang L, Bo XC, et al. China Mobile Laboratory Testing Team in Sierra Leone. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone. Nature. 2015;524(7563):93-6.  https://doi.org/10.1038/nature14490  PMID: 25970247 
  8. Samuel CE. Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral. Virology. 2011;411(2):180-93.  https://doi.org/10.1016/j.virol.2010.12.004  PMID: 21211811 
  9. Cattaneo R, Schmid A, Eschle D, Baczko K, ter Meulen V, Billeter MA. Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell. 1988;55(2):255-65.  https://doi.org/10.1016/0092-8674(88)90048-7  PMID: 3167982 
  10. Shabman RS, Jabado OJ, Mire CE, Stockwell TB, Edwards M, Mahajan M, et al. Deep sequencing identifies noncanonical editing of Ebola and Marburg virus RNAs in infected cells. MBio. 2014;5(6):e02011.  https://doi.org/10.1128/mBio.02011-14  PMID: 25370495 
Genotypic anomaly in Ebola virus strains circulating in Magazine Wharf area, Freetown, Sierra Leone, 2015
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Saskia+L+Smits&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Smits Saskia L</a>, <a href="/search?value1=Suzan+D+Pas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pas Suzan D</a>, <a href="/search?value1=Chantal+B+Reusken&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reusken Chantal B</a>, <a href="/search?value1=Bart+L+Haagmans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Haagmans Bart L</a>, <a href="/search?value1=Peirro+Pertile&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pertile Peirro</a>, <a href="/search?value1=Corrado+Cancedda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cancedda Corrado</a>, <a href="/search?value1=Kerry+Dierberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dierberg Kerry</a>, <a href="/search?value1=Isata+Wurie&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wurie Isata</a>, <a href="/search?value1=Abdul+Kamara&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kamara Abdul</a>, <a href="/search?value1=David+Kargbo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kargbo David</a>, <a href="/search?value1=Sarah+L+Caddy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caddy Sarah L</a>, <a href="/search?value1=Armando+Arias&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Arias Armando</a>, <a href="/search?value1=Lucy+Thorne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Thorne Lucy</a>, <a href="/search?value1=Jia+Lu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lu Jia</a>, <a href="/search?value1=Umaru+Jah&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jah Umaru</a>, <a href="/search?value1=Ian+Goodfellow&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Goodfellow Ian</a>, <a href="/search?value1=Marion+P+Koopmans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koopmans Marion P</a></span>. Genotypic anomaly in Ebola virus strains circulating in Magazine Wharf area, Freetown, Sierra Leone, 2015. <a href="/content/ecdc">Euro Surveill.</a> 2015;20(40):pii=30035. <a href="https://doi.org/10.2807/1560-7917.ES.2015.20.40.30035" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2015.20.40.30035</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Sept 2015;&nbsp;&nbsp; <span class="generated">Accepted</span>: 08 Oct 2015 </span> </p>
/content/10.2807/1560-7917.ES.2015.20.40.30035
/content/10.2807/1560-7917.ES.2015.20.40.30035
Loading

Data & Media loading...

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error