Effectiveness of seasonal 2012/13 vaccine in preventing laboratory-confirmed
influenza infection in primary care in the United Kingdom: mid-season analysis 2012/13

J McMenamin; N Andrews; C Robertson; D M Fleming; H Durnall; B von Wissmann; J Ellis; A Lackenby; S Cottrell; B Smyth; M Zambon; C Moore; J M Watson; R G Pebody

doi:10.2807/ese.18.05.20393-en

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Effectiveness of seasonal 2012/13 vaccine in preventing laboratory-confirmed influenza infection in primary care in the United Kingdom: mid-season analysis 2012/13
J McMenamin¹ , N Andrews² , C Robertson^1,3,4 , D M Fleming⁵ , H Durnall⁵ , B von Wissmann¹ , J Ellis⁶ , A Lackenby⁶ , S Cottrell⁷ , B Smyth⁸ , M Zambon² , C Moore⁷ , J M Watson² , R G Pebody²
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Affiliations: ¹ Health Protection Scotland, Glasgow, United Kingdom ² Health Protection Agency Health Protection Services – Colindale, London, United Kingdom ³ University of Strathclyde, Glasgow, United Kingdom ⁴ International Prevention Research Institute, Lyon, France ⁵ Royal College of General Practitioners Research and Surveillance Centre, Birmingham, United Kingdom ⁶ Health Protection Agency Microbiology Services – Colindale, London, United Kingdom ⁷ Public Health Wales, Cardiff, United Kingdom ⁸ Public Health Agency Northern Ireland, Belfast, United Kingdom

Correspondence:
J McMenamin
jim.mcmenamin nhs.net
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Citation style for this article: McMenamin J, Andrews N, Robertson C, Fleming D M, Durnall H, von Wissmann B, Ellis J, Lackenby A, Cottrell S, Smyth B, Zambon M, Moore C, Watson J M, Pebody R G. Effectiveness of seasonal 2012/13 vaccine in preventing laboratory-confirmed influenza infection in primary care in the United Kingdom: mid-season analysis 2012/13. Euro Surveill. 2013;18(5):pii=20393. https://doi.org/10.2807/ese.18.05.20393-en Received: 28 Jan 2013

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Abstract

The early experience of the United Kingdom (UK) is that influenza B has dominated the influenza 2012/13 season. Overall trivalent influenza vaccine (TIV) adjusted vaccine effectiveness (VE) against all laboratory-confirmed influenza in primary care was 51% (95% confidence interval (CI): 27% to 68%); TIV adjusted VE against influenza A alone or influenza B alone was 49% (95% CI: -2% to 75%) and 52% (95% CI: 23% to 70%) respectively. Vaccination remains the best protection against influenza.