Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012

A Meijer; M Jonges; P van Beek; C M Swaan; A D Osterhaus; R S Daniels; A C Hurt; M P Koopmans

doi:10.2807/ese.17.36.20266-en

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Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012
A Meijer¹ , M Jonges¹ , P van Beek² , C M Swaan² , A D Osterhaus^3,4 , R S Daniels⁵ , A C Hurt⁶ , M P Koopmans^1,4
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Affiliations: ¹ Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands ² Preparedness and Response Unit, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands ³ National Influenza Centre, Erasmus Medical Centre, Rotterdam, the Netherlands ⁴ Viroscience laboratory, Erasmus Medical Centre, Rotterdam, the Netherlands ⁵ World Health Organization Collaborating Centre for Reference and Research on Influenza, Medical Research Council (MRC) National Institute for Medical Research, London, United Kingdom ⁶ World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia

Correspondence:
A Meijer
adam.meijer rivm.nl
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Citation style for this article: Meijer A, Jonges M, van Beek P, Swaan C M, Osterhaus A D, Daniels R S, Hurt A C, Koopmans M P. Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012. Euro Surveill. 2012;17(36):pii=20266. https://doi.org/10.2807/ese.17.36.20266-en Received: 05 Sept 2012

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Abstract

Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.