Carbapenem non-susceptible Klebsiella pneumoniae from Micronet network hospitals, Italy, 2009 to 2012

A Sisto; F D'Ancona; M Meledandri; A Pantosti; G M Rossolini; A Raglio; R Serra; L Dematte; E Aiello; A Goglio; Collective Micronet network participants

doi:10.2807/ese.17.33.20247-en

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Carbapenem non-susceptible Klebsiella pneumoniae from Micronet network hospitals, Italy, 2009 to 2012
A Sisto¹ , F D'Ancona² , M Meledandri³ , A Pantosti² , G M Rossolini⁴ , A Raglio⁵ , R Serra⁶ , L Dematte¹ , E Aiello¹ , A Goglio⁵ , Collective Micronet network participants⁷
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Affiliations: ¹ CINECA – Consortium of universities, Bologna, Italy ² Istituto Superiore Sanità (Italian National Public Health Institute), Rome, Italy ³ Azienda Complessa Ospedaliera San Filippo Neri, Rome, Italy ⁴ University of Sienna, Department of Biotechnologies, Section of Microbiology, and Microbiology and Virology Unit, Sienna University Hospital, Sienna, Italy ⁵ Azienda Ospedaliera Ospedali Riuniti di Bergamo, Bergamo, Italy ⁶ Azienda Ospedaliera S. Giovanni Battista ‘Le Molinette’, Turin, Italy ⁷ The participants are listed at the end of the article

Correspondence:
F D'Ancona
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Citation style for this article: Sisto A, D'Ancona F, Meledandri M, Pantosti A, Rossolini G M, Raglio A, Serra R, Dematte L, Aiello E, Goglio A, Micronet network participants Collective. Carbapenem non-susceptible Klebsiella pneumoniae from Micronet network hospitals, Italy, 2009 to 2012. Euro Surveill. 2012;17(33):pii=20247. https://doi.org/10.2807/ese.17.33.20247-en Received: 17 Jan 2012

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Abstract

Carbapenem-resistant Klebsiella pneumoniae has recently been reported as a new, multidrug-resistant nosocomial pathogen in several hospitals from various Italian regions. Through Micronet, a new Italian sentinel laboratory-based surveillance network, we studied the trend of non-susceptibility of K. pneumoniae to selected carbapenems (imipenem and/or meropenem) in 14 of the 15 hospitals participating in the network. Analysis of data from 1 January 2009 to 30 April 2012 revealed a statistically significant increasing trend (p<0.01) in the proportion of carbapenem non-susceptible K. pneumoniae isolates from clinical specimens (from 2.2 % in 2009 to 19.4% in 2012). The increase in the proportion of non-susceptibility was very large for isolates from the respiratory tract (from 5.3% in 2009 to 38.5% in 2012) and blood (from 5.4% in 2009 to 29.2% in 2012). The results demonstrate the urgent need in Italy for infection control, guidelines, antibiotic stewardship programmes and utilisation of surveillance systems, such as Micronet, which are capable of receiving data from hospitals in real time for many pathogens and types of clinical specimens.