Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010

D M Skowronski; G De Serres; N Z Janjua; J L Gardy; V Gilca; M Dionne; M E Hamelin; C Rhéaume; G Boivin

doi:10.2807/ese.17.04.20066-en

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Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010
D M Skowronski^1,2 , G De Serres^3,4,5 , N Z Janjua^1,2 , J L Gardy^1,2 , V Gilca^3,4,5 , M Dionne^3,4,5 , M E Hamelin^4,5 , C Rhéaume⁵ , G Boivin^4,5
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Affiliations: ¹ British Columbia Centre for Disease Control, Vancouver, Canada ² University of British Columbia, Vancouver, Canada ³ Institut National de Santé Publique du Québec (National Institute of Health of Quebec), Québec, Canada ⁴ Laval University, Quebec, Canada ⁵ Centre Hospitalier Universitaire de Québec (University Hospital Centre of Quebec), Québec, Canada

Correspondence:
D Skowronski
danuta.skowronski bccdc.ca
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Citation style for this article: Skowronski D M, De Serres G, Janjua N Z, Gardy J L, Gilca V, Dionne M, Hamelin M E, Rhéaume C, Boivin G. Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010. Euro Surveill. 2012;17(4):pii=20066. https://doi.org/10.2807/ese.17.04.20066-en Received: 11 Jan 2012

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Abstract

In pre- and post-immunisation sera from children (17-120 months-old) and adults (20-59 years-old) immunised with 2010/11 trivalent inactivated influenza vaccine, we assessed age-related patterns of sero-susceptibility and vaccine-induced cross-reactive antibodies to a representative swine H3N2 (swH3N2) and a related ancestral human H3N2 (A/Sydney/5/1997) influenza virus. Few children but a greater proportion of adults showed pre-immunisation haemagglutination inhibition titres ≥40 to either virus. Titres increased with age among children but decreased in adults. Fewer than 20% showed a four-fold rise in antibody titres to either virus following immunisation. Further investigation is warranted to guide ongoing risk assessment and response to emerging swine H3N2 viruses.