Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation

A C Hurt; R T Lee; S K Leang; L Cui; Y M Deng; S P Phuah; N Caldwell; K Freeman; N Komadina; D Smith; D Speers; A Kelso; R T Lin; S Maurer-Stroh; I G Barr

doi:10.2807/ese.16.23.19884-en

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Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation
A C Hurt¹ , R T Lee² , S K Leang¹ , L Cui³ , Y M Deng¹ , S P Phuah³ , N Caldwell¹ , K Freeman⁴ , N Komadina¹ , D Smith⁵ , D Speers⁵ , A Kelso¹ , R T Lin³ , S Maurer-Stroh^2,3,6 , I G Barr¹
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Affiliations: ¹ World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia ² Bioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), Singapore ³ National Public Health Laboratory, Communicable Diseases Division Ministry of Health, Singapore ⁴ Serology/Molecular Biology Department, Royal Darwin Hospital, Darwin, Australia ⁵ PathWest Laboratory Medicine, Nedlands, Western Australia ⁶ School of Biological Sciences (SBS), Nanyang Technological University (NTU), Singapore

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A Hurt
Aeron.Hurt influenzacentre.org
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Citation style for this article: Hurt A C, Lee R T, Leang S K, Cui L, Deng Y M, Phuah S P, Caldwell N, Freeman K, Komadina N, Smith D, Speers D, Kelso A, Lin R T, Maurer-Stroh S, Barr I G. Increased detection in Australia and Singapore of a novel influenza A(H1N1)2009 variant with reduced oseltamivir and zanamivir sensitivity due to a S247N neuraminidase mutation. Euro Surveill. 2011;16(23):pii=19884. https://doi.org/10.2807/ese.16.23.19884-en Received: 26 May 2011

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Abstract

A novel influenza A(H1N1)2009 variant with mildly reduced oseltamivir and zanamivir sensitivity has been detected in more than 10% of community specimens in Singapore and more than 30% of samples from northern Australia during the early months of 2011. The variant, which has also been detected in other regions of the Asia-Pacific, contains a S247N neuraminidase mutation. When combined with the H275Y mutation, as detected in an oseltamivir-treated patient, the dual S247N+H275Y mutant had extremely high oseltamivir resistance.