Effectiveness of the 2010/11 seasonal trivalent influenza vaccine in Spain: preliminary results of a case–control study

C Savulescu; S Jiménez-Jorge; S de Mateo; J Ledesma; F Pozo; I Casas; A Larrauri; Collective cycEVA Study Team

doi:10.2807/ese.16.11.19820-en

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Effectiveness of the 2010/11 seasonal trivalent influenza vaccine in Spain: preliminary results of a case–control study
C Savulescu^1,2 , S Jiménez-Jorge^2,3 , S de Mateo^2,3 , J Ledesma⁴ , F Pozo⁴ , I Casas⁴ , A Larrauri^2,3 , Collective cycEVA Study Team⁵
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Affiliations: ¹ EpiConcept, Paris, France ² National Centre of Epidemiology, Institute of Health Carlos III, Madrid, Spain ³ Ciber Epidemiología y Salud Pública (CIBERESP), Ministry of Science and Innovation, Institute of Health Carlos III, Spain ⁴ National Influenza Centre-Madrid, National Centre for Microbiology, Institute of Health Carlos III, Madrid, Spain ⁵ Members of the team are listed at the end of the article

Correspondence:
C Savulescu
csavulescu isciii.es
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Citation style for this article: Savulescu C, Jiménez-Jorge S, de Mateo S, Ledesma J, Pozo F, Casas I, Larrauri A, cycEVA Study Team Collective. Effectiveness of the 2010/11 seasonal trivalent influenza vaccine in Spain: preliminary results of a case–control study. Euro Surveill. 2011;16(11):pii=19820. https://doi.org/10.2807/ese.16.11.19820-en Received: 01 Mar 2011

Abstract

We present preliminary results of a case-control study to estimate influenza vaccine effectiveness in Spain, from week 50 of 2010 to week 6 of 2011. The adjusted effectiveness of the vaccine in preventing laboratory-confirmed influenza due to any type of influenza virus was 50% (95% CI: -6 to 77%) for the trivalent seasonal vaccine and 72% (95% CI: 7 to 92%) for both trivalent seasonal and monovalent pandemic vaccines, suggesting a protective effect of seasonal vaccination lower than that reported for the previous season.