Effectiveness of trivalent seasonal and monovalent influenza A(H1N1)2009 vaccines in population with major chronic conditions of Navarre, Spain: 2010/11 mid-season analysis

J Castilla; J Moran; V Martínez-Artola; G Reina; I Martínez-Baz; M García Cenoz; N Alvarez; F Irisarri; M Arriazu; F Elía; E Salcedo

doi:10.2807/ese.16.07.19799-en

Surveillance and outbreak reports Open Access

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Effectiveness of trivalent seasonal and monovalent influenza A(H1N1)2009 vaccines in population with major chronic conditions of Navarre, Spain: 2010/11 mid-season analysis
J Castilla^1,2 , J Moran³ , V Martínez-Artola⁴ , G Reina⁵ , I Martínez-Baz^1,2 , M García Cenoz^1,2 , N Alvarez⁶ , F Irisarri^1,2 , M Arriazu^1,2 , F Elía³ , E Salcedo⁴
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Affiliations: ¹ Instituto de Salud Pública de Navarra (Public Health Institute of Navarre), Pamplona, Spain ² CIBER de Epidemiología y Salud Pública (Biomedical Research Network of Epidemiology and Public Health) ³ Dirección de Atención Primaria, Servicio Navarro de Salud (Primary Health Care Department), Pamplona, Spain ⁴ Complejo Hospitalario de Navarra (Navarre Hospital Complex), Pamplona, Spain ⁵ Clínica Universidad de Navarra (University Clinic of Navarra), Pamplona, Spain ⁶ Servicio Navarro de Salud (Navarre Health Service), Pamplona, Spain

Correspondence:
J Castilla
jcastilc navarra.es
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Citation style for this article: Castilla J, Moran J, Martínez-Artola V, Reina G, Martínez-Baz I, García Cenoz M, Alvarez N, Irisarri F, Arriazu M, Elía F, Salcedo E. Effectiveness of trivalent seasonal and monovalent influenza A(H1N1)2009 vaccines in population with major chronic conditions of Navarre, Spain: 2010/11 mid-season analysis. Euro Surveill. 2011;16(7):pii=19799. https://doi.org/10.2807/ese.16.07.19799-en Received: 03 Feb 2011

Abstract

We defined a cohort of people with major chronic conditions (152,585 subjects) in Navarre, Spain, using electronic records from physicians, to obtain 2010/11 mid-season estimates of influenza vaccine effectiveness. The adjusted estimates of the effectiveness of the 2010/11 trivalent influenza vaccine were 31% (95% confidence interval (CI): 20-40%) in preventing medically attended influenza-like illness, and 58% (95% CI: 11-80%) in preventing laboratory-confirmed influenza. Having received the monovalent influenza A(H1N1)2009 vaccine in the 2009/10 season had an independent preventive effect against medically attended influenza-like illness (17%, 95% CI: 1-30%), and having received both vaccines had 68% (95% CI: 23-87%) effectiveness in preventing laboratory-confirmed influenza.