Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010

G Grard; J F Drexler; S Lekana-Douki; M Caron; A Lukashev; D Nkoghe; J P Gonzalez; C Drosten; E Leroy

doi:10.2807/ese.15.47.19723-en

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Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010
G Grard^1,2 , J F Drexler^2,3 , S Lekana-Douki^1,2 , M Caron¹ , A Lukashev⁴ , D Nkoghe¹ , J P Gonzalez¹ , C Drosten³ , E Leroy^1,2,5
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Affiliations: ¹ Centre International de Recherches Médicales de Franceville (CIRMF, International Centre of Medical Research of Francville), Franceville, Gabon ² These authors contributed equally to this work ³ Institute of Virology, University of Bonn Medical Centre, Bonn, Germany ⁴ Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia ⁵ Institut de Recherche pour le Développement (IRD, Institute of research for development), UMR 224 (MIVEGEC), IRD/CNRS/UM1, Montpellier, France

Correspondence:
E Leroy
eric.leroy ird.fr
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Citation style for this article: Grard G, Drexler J F, Lekana-Douki S, Caron M, Lukashev A, Nkoghe D, Gonzalez J P, Drosten C, Leroy E. Type 1 wild poliovirus and putative enterovirus 109 in an outbreak of acute flaccid paralysis in Congo, October-November 2010. Euro Surveill. 2010;15(47):pii=19723. https://doi.org/10.2807/ese.15.47.19723-en Received: 11 Nov 2010

Abstract

An outbreak of flaccid paralysis syndrome in adults is ongoing in Congo. Molecular analysis of faecal, throat and cerebrospinal samples identified wildtype 1 poliovirus and an additional enterovirus C strain related to enterovirus 109 as the cause. As of 22 November, the cumulative number of cases was 409, of which 169 (41.3%) were fatal. This is one of the largest wild type 1 poliovirus outbreaks ever described associated with an unusually high case fatality rate.