The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009

H Harvala; R Gunson; P Simmonds; A Hardie; S Bennett; F Scott; H Roddie; J McKnight; T Walsh; D Rowney; A Clark; J Bremner; C Aitken; K Templeton

doi:10.2807/ese.15.14.19536-en

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The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009
H Harvala¹ , R Gunson² , P Simmonds³ , A Hardie¹ , S Bennett² , F Scott⁴ , H Roddie⁴ , J McKnight⁵ , T Walsh⁶ , D Rowney⁷ , A Clark^7,8 , J Bremner¹ , C Aitken² , K Templeton¹
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Affiliations: ¹ Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom ² West of Scotland Specialist Virology Centre, Glasgow, United Kingdom ³ Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom ⁴ Department of Haematology, Western General Hospital, Edinburgh, United Kingdom ⁵ Metabolic Unit, Western General Hospital, Edinburgh, United Kingdom ⁶ Intensive Therapy Unit, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom ⁷ Department of Paediatric Haematology, Royal Hospital for Sick Children, Glasgow, United Kingdom ⁸ Bone Marrow Transplant Unit, Gartnaval General Hospital, Gartnavel General Hospital, Glasgow, United Kingdom

Correspondence:
H Harvala
heli.harvala luht.scot.nhs.uk
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Citation style for this article: Harvala H, Gunson R, Simmonds P, Hardie A, Bennett S, Scott F, Roddie H, McKnight J, Walsh T, Rowney D, Clark A, Bremner J, Aitken C, Templeton K. The emergence of oseltamivir-resistant pandemic influenza A(H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009. Euro Surveill. 2010;15(14):pii=19536. https://doi.org/10.2807/ese.15.14.19536-en Received: 01 Apr 2010

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Abstract

To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.