2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals

M Rondy; O Launay; J Puig-Barberà; G Gefenaite; J Castilla; K de Gaetano Donati; F Galtier; E Hak; M Guevara; S Costanzo; Collective European hospital IVE network; A Moren

doi:10.2807/1560-7917.ES2015.20.2.21011

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2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals
M Rondy¹ , O Launay^2,3,4 , J Puig-Barberà⁵ , G Gefenaite^6,7 , J Castilla^8,9 , K de Gaetano Donati¹⁰ , F Galtier^2,11,12 , E Hak^6,7 , M Guevara^8,9 , S Costanzo¹³ , Collective European hospital IVE network¹⁴ , A Moren¹
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Affiliations: ¹ EpiConcept, Paris, France ² French Clinical Vaccinology Network (REIVAC) ³ Cochin hospital, Paris, France ⁴ Institut national de la santé et de la recherche médicale (Inserm), CIC BT 505 Cochin Pasteur, Paris, France ⁵ Vaccines Research, FISABIO-Public Health, Valencia, Spain ⁶ Department of Pharmacy, Unit of Pharmaco-Epidemiology & Pharmaco-Economics (PE2), University of Groningen, Groningen, the Netherlands ⁷ Department of Epidemiology, University Medical Centre Groningen, Groningen, the Netherlands ⁸ Instituto de Salud Pública de Navarra, Pamplona, Spain ⁹ Centro de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain ¹⁰ Department of Infectious Disease, Catholic University, Rome, Italy ¹¹ Centre hospitalier régional universitaire (CHRU) Montpellier, Hôpital Saint Eloi, Montpellier, France ¹² Inserm, CIC 1001, Montpellier, France ¹³ Department of Epidemiology and Prevention, IRCCS Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy ¹⁴ Members are listed at the end of the article

Correspondence:
M Rondy
m.rondy epiconcept.fr
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Citation style for this article: Rondy M, Launay O, Puig-Barberà J, Gefenaite G, Castilla J, de Gaetano Donati K, Galtier F, Hak E, Guevara M, Costanzo S, European hospital IVE network Collective, Moren A. 2012/13 influenza vaccine effectiveness against hospitalised influenza A(H1N1)pdm09, A(H3N2) and B: estimates from a European network of hospitals. Euro Surveill. 2015;20(2):pii=21011. https://doi.org/10.2807/1560-7917.ES2015.20.2.21011 Received: 07 May 2014

Abstract

While influenza vaccines aim to decrease the incidence of severe influenza among high-risk groups, evidence of influenza vaccine effectiveness (IVE) among the influenza vaccine target population is sparse. We conducted a multicentre test-negative case-control study to estimate IVE against hospitalised laboratory-confirmed influenza in the target population in 18 hospitals in France, Italy, Lithuania and the Navarre and Valencia regions in Spain. All hospitalised patients aged?≥18 years, belonging to the target population presenting with influenza-like illness symptom onset within seven days were swabbed. Patients positive by reverse transcription polymerase chain reaction for influenza virus were cases and those negative were controls. Using logistic regression, we calculated IVE for each influenza virus subtype and adjusted it for month of symptom onset, study site, age and chronic conditions. Of the 1,972 patients included, 116 were positive for influenza A(H1N1)pdm09, 58 for A(H3N2) and 232 for influenza B. Adjusted IVE was 21.3% (95% confidence interval (CI): -25.2 to 50.6; n=1,628), 61.8% (95% CI: 26.8 to 80.0; n=557) and 43.1% (95% CI: 21.2 to 58.9; n=1,526) against influenza A(H1N1)pdm09, A(H3N2) and B respectively. Our results suggest that the 2012/13 IVE was moderate against influenza A(H3N2) and B and low against influenza A(H1N1)pdm09. .