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Abstract

The monoclonal antibody nirsevimab was at least 70% effective in preventing hospitalisations in infants with lower respiratory tract infections (LRTI) positive for respiratory syncytial virus (RSV) in Spain (Oct 2023–Jan 2024), where a universal immunisation programme began late September (coverage range: 79–99%). High protection was confirmed by two methodological designs (screening and test-negative) in a multicentre active surveillance in nine hospitals in three regions. No protection against RSV-negative LRTI-hospitalisations was shown. These interim results could guide public-health decision-making.

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/content/10.2807/1560-7917.ES.2024.29.6.2400046
2024-02-08
2024-12-19
/content/10.2807/1560-7917.ES.2024.29.6.2400046
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Early estimates of nirsevimab immunoprophylaxis effectiveness against hospital admission for respiratory syncytial virus lower respiratory tract infections in infants, Spain, October 2023 to January 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=M%C3%B3nica+L%C3%B3pez-Lacort&option1=author&noRedirect=true" class="nonDisambigAuthorLink">López-Lacort Mónica</a>, <a href="/search?value1=Cintia+Mu%C3%B1oz-Quiles&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Muñoz-Quiles Cintia</a>, <a href="/search?value1=Ainara+Mira-Iglesias&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mira-Iglesias Ainara</a>, <a href="/search?value1=F+Xavier+L%C3%B3pez-Labrador&option1=author&noRedirect=true" class="nonDisambigAuthorLink">López-Labrador F Xavier</a>, <a href="/search?value1=Beatriz+Mengual-Chuli%C3%A1&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mengual-Chuliá Beatriz</a>, <a href="/search?value1=Carlos+Fern%C3%A1ndez-Garc%C3%ADa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fernández-García Carlos</a>, <a href="/search?value1=Mario+Carballido-Fern%C3%A1ndez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carballido-Fernández Mario</a>, <a href="/search?value1=Ana+Pineda-Caplliure&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pineda-Caplliure Ana</a>, <a href="/search?value1=Juan+Mollar-Maseres&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mollar-Maseres Juan</a>, <a href="/search?value1=Maruan+Shalabi+Benavent&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Shalabi Benavent Maruan</a>, <a href="/search?value1=Francisco+Sanz-Herrero&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sanz-Herrero Francisco</a>, <a href="/search?value1=Matilde+Zornoza-Moreno&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zornoza-Moreno Matilde</a>, <a href="/search?value1=Jaime+Jes%C3%BAs+P%C3%A9rez-Mart%C3%ADn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez-Martín Jaime Jesús</a>, <a href="/search?value1=Santiago+Alfayate-Miguelez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alfayate-Miguelez Santiago</a>, <a href="/search?value1=Roc%C3%ADo+P%C3%A9rez+Crespo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez Crespo Rocío</a>, <a href="/search?value1=Encarnaci%C3%B3n+Bastida+S%C3%A1nchez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bastida Sánchez Encarnación</a>, <a href="/search?value1=Ana+Isabel+Menasalvas-Ruiz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Menasalvas-Ruiz Ana Isabel</a>, <a href="/search?value1=M%C2%AA+Cinta+T%C3%A9llez-Gonz%C3%A1lez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Téllez-González Mª Cinta</a>, <a href="/search?value1=Samuel+Esquiva+Soto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Esquiva Soto Samuel</a>, <a href="/search?value1=Carlos+Del+Toro+Saravia&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Del Toro Saravia Carlos</a>, <a href="/search?value1=Iv%C3%A1n+Sanz-Mu%C3%B1oz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sanz-Muñoz Iván</a>, <a href="/search?value1=Jos%C3%A9+Mar%C3%ADa+Eiros&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eiros José María</a>, <a href="/search?value1=Vanesa+Mat%C3%ADas+Del+Pozo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matías Del Pozo Vanesa</a>, <a href="/search?value1=Marina+Toquero-Asensi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Toquero-Asensi Marina</a>, <a href="/search?value1=Eliseo+Pastor-Villalba&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pastor-Villalba Eliseo</a>, <a href="/search?value1=Jos%C3%A9+Antonio+Lluch-Rodrigo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lluch-Rodrigo José Antonio</a>, <a href="/search?value1=Javier+D%C3%ADez-Domingo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Díez-Domingo Javier</a>, <a href="/search?value1=Alejandro+Orrico-S%C3%A1nchez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Orrico-Sánchez Alejandro</a></span>. Early estimates of nirsevimab immunoprophylaxis effectiveness against hospital admission for respiratory syncytial virus lower respiratory tract infections in infants, Spain, October 2023 to January 2024. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(6):pii=2400046. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.6.2400046" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.6.2400046</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Jan 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 06 Feb 2024 </span> </p>
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/content/10.2807/1560-7917.ES.2024.29.6.2400046
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