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Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
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Anke Kohlenberg1
,
Olov Svartström1
,
Petra Apfalter2
,
Rainer Hartl2
,
Pierre Bogaerts3
,
Te-Din Huang3
,
Katerina Chudejova4
,
Lucia Malisova5,6
,
Jessica Eisfeld7
,
Mirco Sandfort8
,
Anette M Hammerum9
,
Louise Roer9
,
Kati Räisänen10
,
Laurent Dortet11,12
,
Rémy A Bonnin11,12
,
Ákos Tóth13
,
Kinga Tóth13
,
Christina Clarke14
,
Martin Cormican15
,
Algirdas Griškevičius16
,
Kirstin Khonyongwa17
,
Marie Meo17
,
Baiba Niedre-Otomere18
,
Reinis Vangravs18
,
Antoni PA Hendrickx19
,
Daan W Notermans19
,
Ørjan Samuelsen20
,
Manuela Caniça21
,
Vera Manageiro21
,
Vilhelm Müller22
,
Barbro Mäkitalo22
,
Urška Kramar23
,
Mateja Pirs24
,
Daniel Palm1
,
Dominique L Monnet1
,
Erik Alm1
,
Marius Linkevicius1
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View Affiliations Hide AffiliationsAffiliations: 1 European Centre for Disease Prevention and Control, Stockholm, Sweden 2 Austrian National Reference Centre for Antimicrobial Resistance, Ordensklinikum Linz Elisabethinen, Linz, Austria 3 National Reference Centre for Antimicrobic-Resistant Gram-Negative Bacilli, Laboratory of Microbiology, CHU UCL Namur, Yvoir, Belgium 4 Department of Microbiology, Faculty of Medicine, University Hospital in Pilsen, Charles University, Pilsen, Czechia 5 National Reference Laboratory for Antibiotics, National Institute of Public Health, Prague, Czechia 6 Department of Microbiology, 3rd Faculty of Medicine, Charles University, University Hospital Kralovske Vinohrady and National Institute of Public Health, Prague, Czechia 7 German National Reference Centre for Multidrug-resistant Gram-negative Bacteria, Department of Medical Microbiology, Ruhr-University Bochum, Bochum, Germany 8 Department of Infectious Disease Epidemiology, Robert Koch Institute, Berlin, Germany 9 National Reference Laboratory for Antimicrobial Resistance, Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark 10 Finnish Institute for Health and Welfare, Helsinki, Finland 11 Associated French National Reference Centre for Antibiotic Resistance: Carbapenemase-Producing Enterobacteriaceae, Le Kremlin-Bicêtre, France 12 Team “Resist” UMR1184 “Immunology of Viral, Auto-Immune, Hematological and Bacterial diseases (IMVA-HB)”, INSERM, Université Paris-Saclay, CEA, IHU Prometheus Faculty of Medicine, Le Kremlin-Bicêtre, France 13 National Centre for Public Health and Pharmacy, Budapest, Hungary 14 Galway Reference Laboratory Service, Galway University Hospital, Galway, Ireland 15 School of Medicine, University of Galway, Galway, Ireland 16 National Public Health Surveillance Laboratory, Vilnius, Lithuania 17 Service Bactériologie-Mycologie-Antibiorésistance-Hygiène Hospitalière, Département de Microbiologie, Laboratoire National de Santé, Dudelange, Luxembourg 18 National Microbiology Reference Laboratory of Latvia, Laboratory “Latvian Centre of Infectious Diseases”, Laboratory Service, Riga East University Hospital, Riga, Latvia 19 Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands 20 Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway 21 National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Dr Ricardo Jorge, Lisbon, Portugal 22 Public Health Agency of Sweden, Solna, Sweden 23 National Laboratory of Health, Environment and Food, Centre for Medical Microbiology, Maribor, Slovenia 24 Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Ljubljana, SloveniaCorrespondence:Anke KohlenbergAnke.Kohlenberg ecdc.europa.eu
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Citation style for this article: Kohlenberg Anke, Svartström Olov, Apfalter Petra, Hartl Rainer, Bogaerts Pierre, Huang Te-Din, Chudejova Katerina, Malisova Lucia, Eisfeld Jessica, Sandfort Mirco, Hammerum Anette M, Roer Louise, Räisänen Kati, Dortet Laurent, Bonnin Rémy A, Tóth Ákos, Tóth Kinga, Clarke Christina, Cormican Martin, Griškevičius Algirdas, Khonyongwa Kirstin, Meo Marie, Niedre-Otomere Baiba, Vangravs Reinis, Hendrickx Antoni PA, Notermans Daan W, Samuelsen Ørjan, Caniça Manuela, Manageiro Vera, Müller Vilhelm, Mäkitalo Barbro, Kramar Urška, Pirs Mateja, Palm Daniel, Monnet Dominique L, Alm Erik, Linkevicius Marius. Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024. Euro Surveill. 2024;29(47):pii=2400727. https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400727 Received: 03 Nov 2024; Accepted: 20 Nov 2024
Abstract
Analysis of 594 isolates of Escherichia coli sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were blaOXA-244 (n = 230) and blaOXA-48 (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying blaOXA-244 have increased rapidly since 2021. The increasing detection of carbapenemase genes in the E. coli high-risk lineage ST131 is a public health concern.
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2024-11-21
2024-11-22
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References
-
Murray CJL, Ikuta KS, Sharara F, Swetschinski L, Robles Aguilar G, Gray A, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet. 2022;399(10325):629-55. https://doi.org/10.1016/S0140-6736(21)02724-0 PMID: 35065702
-
Mathers AJ, Peirano G, Pitout JD. The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae. Clin Microbiol Rev. 2015;28(3):565-91. https://doi.org/10.1128/CMR.00116-14 PMID: 25926236
-
Welker S, Boutin S, Miethke T, Heeg K, Nurjadi D. Emergence of carbapenem-resistant ST131 Escherichia coli carrying blaOXA-244 in Germany, 2019 to 2020. Euro Surveill. 2020;25(46):2001815. https://doi.org/10.2807/1560-7917.ES.2020.25.46.2001815 PMID: 33213685
-
Piazza A, Corbella M, Mattioni Marchetti V, Merla C, Mileto I, Kuka A, et al. Clinical isolates of ST131 blaOXA-244-positive Escherichia coli, Italy, December 2022 to July 2023. Euro Surveill. 2024;29(8):2400073. https://doi.org/10.2807/1560-7917.ES.2024.29.8.2400073 PMID: 38390649
-
Patiño-Navarrete R, Rosinski-Chupin I, Cabanel N, Zongo PD, Héry M, Oueslati S, et al. Specificities and Commonalities of Carbapenemase-Producing Escherichia coli Isolated in France from 2012 to 2015. mSystems. 2022;7(1):e0116921. https://doi.org/10.1128/msystems.01169-21 PMID: 35014866
-
Bankevich A, Nurk S, Antipov D, Gurevich AA, Dvorkin M, Kulikov AS, et al. SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing. J Comput Biol. 2012;19(5):455-77. https://doi.org/10.1089/cmb.2012.0021 PMID: 22506599
-
Kolmogorov M, Yuan J, Lin Y, Pevzner PA. Assembly of long, error-prone reads using repeat graphs. Nat Biotechnol. 2019;37(5):540-6. https://doi.org/10.1038/s41587-019-0072-8 PMID: 30936562
-
Silva M, Machado MP, Silva DN, Rossi M, Moran-Gilad J, Santos S, et al. chewBBACA: A complete suite for gene-by-gene schema creation and strain identification. Microb Genom. 2018;4(3):e000166. https://doi.org/10.1099/mgen.0.000166 PMID: 29543149
-
Zhou Z, Alikhan NF, Mohamed K, Fan Y, Achtman M, Agama Study Group. The EnteroBase user’s guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny, and Escherichia core genomic diversity. Genome Res. 2020;30(1):138-52. https://doi.org/10.1101/gr.251678.119 PMID: 31809257
-
Larsen MV, Cosentino S, Rasmussen S, Friis C, Hasman H, Marvig RL, et al. Multilocus sequence typing of total-genome-sequenced bacteria. J Clin Microbiol. 2012;50(4):1355-61. https://doi.org/10.1128/JCM.06094-11 PMID: 22238442
-
Wirth T, Falush D, Lan R, Colles F, Mensa P, Wieler LH, et al. Sex and virulence in Escherichia coli: an evolutionary perspective. Mol Microbiol. 2006;60(5):1136-51. https://doi.org/10.1111/j.1365-2958.2006.05172.x PMID: 16689791
-
Roer L, Tchesnokova V, Allesøe R, Muradova M, Chattopadhyay S, Ahrenfeldt J, et al. Development of a web tool for Escherichia coli subtyping based on fimH alleles. J Clin Microbiol. 2017;55(8):2538-43. https://doi.org/10.1128/JCM.00737-17 PMID: 28592545
-
Bortolaia V, Kaas RS, Ruppe E, Roberts MC, Schwarz S, Cattoir V, et al. ResFinder 4.0 for predictions of phenotypes from genotypes. J Antimicrob Chemother. 2020;75(12):3491-500. https://doi.org/10.1093/jac/dkaa345 PMID: 32780112
-
Schürch AC, Arredondo-Alonso S, Willems RJL, Goering RV. Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene-based approaches. Clin Microbiol Infect. 2018;24(4):350-4. https://doi.org/10.1016/j.cmi.2017.12.016 PMID: 29309930
-
Manges AR, Geum HM, Guo A, Edens TJ, Fibke CD, Pitout JDD. Global extraintestinal pathogenic Escherichia coli (ExPEC) lineages. Clin Microbiol Rev. 2019;32(3):e00135-18. https://doi.org/10.1128/CMR.00135-18 PMID: 31189557
-
Emeraud C, Biez L, Girlich D, Jousset AB, Naas T, Bonnin RA, et al. Screening of OXA-244 producers, a difficult-to-detect and emerging OXA-48 variant? J Antimicrob Chemother. 2020;75(8):2120-3. https://doi.org/10.1093/jac/dkaa155 PMID: 32363407
-
Peirano G, Bradford PA, Kazmierczak KM, Badal RE, Hackel M, Hoban DJ, et al. Global incidence of carbapenemase-producing Escherichia coli ST131. Emerg Infect Dis. 2014;20(11):1928-31. https://doi.org/10.3201/eid2011.141388 PMID: 25340464
-
Peirano G, Chen L, Nobrega D, Finn TJ, Kreiswirth BN, DeVinney R, et al. Genomic epidemiology of global carbapenemase-producing Escherichia coli, 2015-2017. Emerg Infect Dis. 2022;28(5):924-31. https://doi.org/10.3201/eid2805.212535 PMID: 35451367
-
Pitout JDD, Finn TJ. The evolutionary puzzle of Escherichia coli ST131. Infect Genet Evol. 2020;81:104265. https://doi.org/10.1016/j.meegid.2020.104265 PMID: 32112974
-
Gladstone RA, McNally A, Pöntinen AK, Tonkin-Hill G, Lees JA, Skytén K, et al. Emergence and dissemination of antimicrobial resistance in Escherichia coli causing bloodstream infections in Norway in 2002-17: a nationwide, longitudinal, microbial population genomic study. Lancet Microbe. 2021;2(7):e331-41. https://doi.org/10.1016/S2666-5247(21)00031-8 PMID: 35544167
-
Stoesser N, Sheppard AE, Pankhurst L, De Maio N, Moore CE, Sebra R, et al. Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131. MBio. 2016;7(2):e02162. https://doi.org/10.1128/mBio.02162-15 PMID: 27006459
-
Linkevicius M, Bonnin RA, Alm E, Svartström O, Apfalter P, Hartl R, et al. Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022. Euro Surveill. 2023;28(19):2300209. https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209 PMID: 37166762
-
European Centre for Disease Prevention and Control (ECDC). Rapid risk assessment: Increase in OXA-244-producing Escherichia coli in the European Union/European Economic Area and the UK since 2013, first update. Stockholm: ECDC; 2021. Available from: https://www.ecdc.europa.eu/en/publications-data/rapid-risk-assessment-increase-oxa-244-producing-escherichia-coli-eu-eea
-
Haidar G, Clancy CJ, Shields RK, Hao B, Cheng S, Nguyen MH. Mutations in blaKPC-3 that confer ceftazidime-avibactam resistance encode novel KPC-3 variants that function as extended-spectrum β-lactamases. Antimicrob Agents Chemother. 2017;61(5):e02534-16. https://doi.org/10.1128/AAC.02534-16 PMID: 28223379
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024
<p class="citation">
<span>Citation style for this article:</span>
<span class="meta-value authors">
<a href="/search?value1=Anke+Kohlenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kohlenberg Anke</a>,
<a href="/search?value1=Olov+Svartstr%C3%B6m&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Svartström Olov</a>,
<a href="/search?value1=Petra+Apfalter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Apfalter Petra</a>,
<a href="/search?value1=Rainer+Hartl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hartl Rainer</a>,
<a href="/search?value1=Pierre+Bogaerts&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bogaerts Pierre</a>,
<a href="/search?value1=Te-Din+Huang&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Huang Te-Din</a>,
<a href="/search?value1=Katerina+Chudejova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chudejova Katerina</a>,
<a href="/search?value1=Lucia+Malisova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Malisova Lucia</a>,
<a href="/search?value1=Jessica+Eisfeld&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eisfeld Jessica</a>,
<a href="/search?value1=Mirco+Sandfort&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sandfort Mirco</a>,
<a href="/search?value1=Anette+M+Hammerum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hammerum Anette M</a>,
<a href="/search?value1=Louise+Roer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roer Louise</a>,
<a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>,
<a href="/search?value1=Laurent+Dortet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dortet Laurent</a>,
<a href="/search?value1=R%C3%A9my+A+Bonnin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bonnin Rémy A</a>,
<a href="/search?value1=%C3%81kos+T%C3%B3th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tóth Ákos</a>,
<a href="/search?value1=Kinga+T%C3%B3th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tóth Kinga</a>,
<a href="/search?value1=Christina+Clarke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Clarke Christina</a>,
<a href="/search?value1=Martin+Cormican&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cormican Martin</a>,
<a href="/search?value1=Algirdas+Gri%C5%A1kevi%C4%8Dius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Griškevičius Algirdas</a>,
<a href="/search?value1=Kirstin+Khonyongwa&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Khonyongwa Kirstin</a>,
<a href="/search?value1=Marie+Meo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Meo Marie</a>,
<a href="/search?value1=Baiba+Niedre-Otomere&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Niedre-Otomere Baiba</a>,
<a href="/search?value1=Reinis+Vangravs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vangravs Reinis</a>,
<a href="/search?value1=Antoni+PA+Hendrickx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hendrickx Antoni PA</a>,
<a href="/search?value1=Daan+W+Notermans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Notermans Daan W</a>,
<a href="/search?value1=%C3%98rjan+Samuelsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Samuelsen Ørjan</a>,
<a href="/search?value1=Manuela+Cani%C3%A7a&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caniça Manuela</a>,
<a href="/search?value1=Vera+Manageiro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Manageiro Vera</a>,
<a href="/search?value1=Vilhelm+M%C3%BCller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Müller Vilhelm</a>,
<a href="/search?value1=Barbro+M%C3%A4kitalo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mäkitalo Barbro</a>,
<a href="/search?value1=Ur%C5%A1ka+Kramar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kramar Urška</a>,
<a href="/search?value1=Mateja+Pirs&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pirs Mateja</a>,
<a href="/search?value1=Daniel+Palm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palm Daniel</a>,
<a href="/search?value1=Dominique+L+Monnet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monnet Dominique L</a>,
<a href="/search?value1=Erik+Alm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alm Erik</a>,
<a href="/search?value1=Marius+Linkevicius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Linkevicius Marius</a></span>.
Emergence of Escherichia coli ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024.
<a href="/content/ecdc">Euro Surveill.</a> 2024;29(47):pii=2400727.
<a href="https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400727" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400727</a>
<span class="ES_Article_citation">
<span class="generated">Received</span>: 03 Nov 2024;
<span class="generated">Accepted</span>: 20 Nov 2024
</span>
</p>
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