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SDG 3: Antimicrobial resistance

Abstract

To reduce antimicrobial resistance (AMR), pathogen-specific AMR burden data are crucial to guide target selection for research and development of vaccines and monoclonal antibodies (mAbs). We identified knowledge gaps through previously conducted systematic reviews, which informed a Delphi expert consultation on future AMR research priorities and harmonisation strategies to support data-driven decision-making. Consensus (≥80% agreement) on importance and feasibility of research topics was achieved in two rounds, involving 24 of 39 and 19 of 24 invited experts, respectively. Priority pathogens and resistance profiles for future research were identified: third generation cephalosporin-resistant and for bloodstream and urinary tract infections, respectively, and meticillin-resistant for surgical-site infections. Prioritised high-risk populations included surgical, haemato-oncological and transplant patients. Mortality and resource use were prioritised as health-economic outcomes. The importance of age-stratified data and inclusion of a non-infected comparator group were highlighted. This agenda provides guidance for future research to fill knowledge gaps and support data-driven selection of target pathogens and populations for new preventive and treatment strategies, specifically vaccines and mAbs, to effectively address the AMR burden in Europe. These research priorities are also relevant to improve the evidence base for future AMR burden estimates.

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2024-11-21
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.47.2400212
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Expert consensus on antimicrobial resistance research priorities to focus development and implementation of antibacterial vaccines and monoclonal antibodies
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Nasreen+Hassoun-Kheir&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hassoun-Kheir Nasreen</a>, <a href="/search?value1=Mariana+Guedes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guedes Mariana</a>, <a href="/search?value1=Fabiana+Arieti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Arieti Fabiana</a>, <a href="/search?value1=Maria+Diletta+Pezzani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pezzani Maria Diletta</a>, <a href="/search?value1=Beryl+Primrose+Gladstone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gladstone Beryl Primrose</a>, <a href="/search?value1=Julie+V+Robotham&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robotham Julie V</a>, <a href="/search?value1=Koen+B+Pouwels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pouwels Koen B</a>, <a href="/search?value1=Rhys+Kingston&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kingston Rhys</a>, <a href="/search?value1=Yehuda+Carmeli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carmeli Yehuda</a>, <a href="/search?value1=Alessandro+Cassini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cassini Alessandro</a>, <a href="/search?value1=Michele+Cecchini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cecchini Michele</a>, <a href="/search?value1=Francis+Drobniewski&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drobniewski Francis</a>, <a href="/search?value1=Isabel+Frost&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Frost Isabel</a>, <a href="/search?value1=Jeroen+Geurtsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Geurtsen Jeroen</a>, <a href="/search?value1=Andreas+Kronenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kronenberg Andreas</a>, <a href="/search?value1=Mila+Nu+Nu+Htay&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Htay Mila Nu Nu</a>, <a href="/search?value1=Mical+Paul&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paul Mical</a>, <a href="/search?value1=Nuno+Rocha-Pereira&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rocha-Pereira Nuno</a>, <a href="/search?value1=Jes%C3%BAs+Rodr%C3%ADguez-Ba%C3%B1o&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rodríguez-Baño Jesús</a>, <a href="/search?value1=Luigia+Scudeller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scudeller Luigia</a>, <a href="/search?value1=Andrew+J+Stewardson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stewardson Andrew J</a>, <a href="/search?value1=Evelina+Tacconelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tacconelli Evelina</a>, <a href="/search?value1=Stephan+Harbarth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Harbarth Stephan</a>, <a href="/search?value1=Venanzio+Vella&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vella Venanzio</a>, <a href="/search?value1=Marlieke+EA+de+Kraker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Kraker Marlieke EA</a></span>. Expert consensus on antimicrobial resistance research priorities to focus development and implementation of antibacterial vaccines and monoclonal antibodies. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(47):pii=2400212. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400212" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.47.2400212</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 05 Apr 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 07 Oct 2024 </span> </p>
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