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Abstract

After the start of the COVID-19 pandemic, a rapid rise in reported numbers and wide geographic spread of -related invasive infections has been observed globally. However, the contemporary epidemiology of fungaemias in Greece remains unknown. An outbreak of bloodstream infections has been ongoing for almost 3 years in a Greek tertiary care academic hospital, with 89 -driven episodes appearing in five waves every 6–7 months following peaks in colonisation rates by 3–4 months. All isolates clustered in clade I and were genetically related, 84% were fluconazole-resistant and all were non-resistant to amphotericin B and echinocandins, except one pan-echinocandin-resistant isolate ( mutant) recovered from a patient on empiric therapy with anidulafungin. Notably, was in 2023 the most prevalent (34%) cause of candidaemia in our hospital. The accelerated and long-term transmission dynamics of fungaemia underscore the need for rigorous infection control measures, while antifungal stewardship is warranted to contain the selection of echinocandin-resistant isolates.

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/content/10.2807/1560-7917.ES.2024.29.45.2400128
2024-11-07
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.45.2400128
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Candida auris fungaemia outbreak in a tertiary care academic hospital and emergence of a pan-echinocandin resistant isolate, Greece, 2021 to 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Joseph+Meletiadis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Meletiadis Joseph</a>, <a href="/search?value1=Maria+Siopi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Siopi Maria</a>, <a href="/search?value1=Bram+Spruijtenburg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Spruijtenburg Bram</a>, <a href="/search?value1=Panagiota-Christina+Georgiou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Georgiou Panagiota-Christina</a>, <a href="/search?value1=Maria+Kostoula&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kostoula Maria</a>, <a href="/search?value1=Sophia+Vourli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vourli Sophia</a>, <a href="/search?value1=Frantzeska+Frantzeskaki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Frantzeskaki Frantzeska</a>, <a href="/search?value1=Elisabeth+Paramythiotou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Paramythiotou Elisabeth</a>, <a href="/search?value1=Jacques+F+Meis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Meis Jacques F</a>, <a href="/search?value1=Iraklis+Tsangaris&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tsangaris Iraklis</a>, <a href="/search?value1=Spyros+Pournaras&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pournaras Spyros</a></span>. Candida auris fungaemia outbreak in a tertiary care academic hospital and emergence of a pan-echinocandin resistant isolate, Greece, 2021 to 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(45):pii=2400128. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.45.2400128" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.45.2400128</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Feb 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 May 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.45.2400128
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