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Abstract

Background

Long-term effectiveness data on bivalent COVID-19 boosters are limited.

Aim

We evaluated the long-term protection of bivalent boosters against severe COVID-19 among ≥ 65-year-olds in Finland.

Methods

In this register-based cohort analysis, we compared the risk of three severe COVID-19 outcomes among ≥ 65-year-olds who received a bivalent booster (Original/Omicron BA.1 or Original/BA.4–5; exposed group) between 1/9/2022 and 31/8/2023 to those who did not (unexposed). We included individuals vaccinated with at least two monovalent COVID-19 vaccine doses before 1/9/2022 and ≥ 3 months ago. The analysis was divided into two periods: 1/9/2022–28/2/2023 (BA.5 and BQ.1.X predominating) and 1/3/2023–31/8/2023 (XBB predominating). The hazards for the outcomes between exposed and unexposed individuals were compared with Cox regression.

Results

We included 1,191,871 individuals. From 1/9/2022 to 28/2/2023, bivalent boosters were associated with a reduced risk of hospitalisation due to COVID-19 (hazard ratio (HR): 0.45; 95% confidence interval (CI): 0.37–0.55), death due to COVID-19 (HR: 0.49; 95% CI: 0.38–0.62), and death in which COVID-19 was a contributing factor (HR: 0.40; 95% CI: 0.31–0.51) during 14–60 days since vaccination. From 1/3/2023 to 31/8/2023, bivalent boosters were associated with lower risks of all three severe COVID-19 outcomes during 61–120 days since a bivalent booster (e.g. HR: 0.53; 95% CI: 0.39–0.71 for hospitalisation due to COVID-19); thereafter no notable risk reduction was observed. No difference was found between Original/Omicron BA.1 and Original/BA.4–5 boosters.

Conclusion

Bivalent boosters initially reduced the risk of severe COVID-19 outcomes by ca 50% among ≥ 65-year-olds, but protection waned over time. These findings help guide vaccine development and vaccination programmes.

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2024-09-12
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.37.2300587
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Relative effectiveness of bivalent boosters against severe COVID-19 outcomes among people aged ≥ 65 years in Finland, September 2022 to August 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Eero+Poukka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Poukka Eero</a>, <a href="/search?value1=Jori+Per%C3%A4l%C3%A4&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Perälä Jori</a>, <a href="/search?value1=Hanna+Nohynek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nohynek Hanna</a>, <a href="/search?value1=Sirkka+Goebeler&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Goebeler Sirkka</a>, <a href="/search?value1=Kari+Auranen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Auranen Kari</a>, <a href="/search?value1=Tuija+Leino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leino Tuija</a>, <a href="/search?value1=Ulrike+Baum&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baum Ulrike</a></span>. Relative effectiveness of bivalent boosters against severe COVID-19 outcomes among people aged ≥ 65 years in Finland, September 2022 to August 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(37):pii=2300587. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.37.2300587" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.37.2300587</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 Oct 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 28 Apr 2024 </span> </p>
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