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Abstract

is a Gram-negative rod which may cause invasive infections when they contaminate liquid medical products. After was detected in blood cultures and a stem cell product from three patients in a tertiary care hospital in Germany, whole genome sequencing of these three isolates and two water isolates from the environment was performed. Core genome multilocus sequence typing analysis showed that the three patient isolates were closely related and there was a large distance to the environmental isolates. In a genomic comparison, the patients’ isolates were distantly related to an strain from a cluster in Australia suspected to be caused by contaminated saline produced in India, while all liquid medical products with a link to all patients were produced in Europe or the United States. Our data point towards an ongoing risk by an unknown common source that could be traced back to medical products contaminated with and potentially distributed worldwide. Investigating invasive infections, identifying and testing medical products administered to the patients and timely whole genome sequencing may help identify the exact source of this potentially global outbreak.

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/content/10.2807/1560-7917.ES.2024.29.3.2400010
2024-01-18
2024-12-26
/content/10.2807/1560-7917.ES.2024.29.3.2400010
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Ralstonia pickettii bloodstream infections with potential genomic link to internationally distributed contaminated saline solution, Germany, October 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Manuel+Krone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Krone Manuel</a>, <a href="/search?value1=Vera+Rauschenberger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rauschenberger Vera</a>, <a href="/search?value1=Vera+Blaschke&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blaschke Vera</a>, <a href="/search?value1=Heike+Claus&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Claus Heike</a>, <a href="/search?value1=Oliver+Kurzai&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kurzai Oliver</a>, <a href="/search?value1=Stefanie+Kampmeier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kampmeier Stefanie</a></span>. Ralstonia pickettii bloodstream infections with potential genomic link to internationally distributed contaminated saline solution, Germany, October 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(3):pii=2400010. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.3.2400010" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.3.2400010</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Jan 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 12 Jan 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.3.2400010
/content/10.2807/1560-7917.ES.2024.29.3.2400010
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