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Abstract

We describe an outbreak of in the United Kingdom, with isolates genetically indistinguishable from a 2023 Australian outbreak linked to internationally distributed saline solutions. Confirmed cases (n = 3) had bacteraemia, clinically relevant infection, indwelling venous lines and frequent healthcare contact. Multi-stakeholder intervention was required including product recall and risk communications. We recommend a low threshold for investigating clusters of species and similar opportunistic pathogens, considering contaminated product sources. Effective mitigation requires multi-agency partnership and international collaboration.

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/content/10.2807/1560-7917.ES.2024.29.27.2400384
2024-07-04
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.27.2400384
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References

  1. Therapeutic Goods Administration (TGA). Recall: Logiwash and Legency Remedies Sodium Chloride 0.9% ampoules. Canberra: TGA; 18 Dec 2023. Available from: https://www.tga.gov.au/safety/product-recalls/recall-logiwash-and-legency-remedies-sodium-chloride-09-ampoules
  2. Therapeutic Goods Administration (TGA). Recall: Interpharma Sodium Chloride 0.9% 30mL ampoules: Canberra: TGA; 1 Dec 2023. Available from: https://www.tga.gov.au/safety/product-recalls/recall-interpharma-sodium-chloride-09-30ml-ampoules
  3. Krone M, Rauschenberger V, Blaschke V, Claus H, Kurzai O, Kampmeier S. Ralstonia pickettii bloodstream infections with potential genomic link to internationally distributed contaminated saline solution, Germany, October 2023. Euro Surveill. 2024;29(3):2400010.  https://doi.org/10.2807/1560-7917.ES.2024.29.3.2400010  PMID: 38240062 
  4. New South Wales Health Pathology (NSW Health Pathology). Genome assembly ASM3380453v1. Newcastle: NSW Health Pathology; 2023. Available from: https://pathology.health.nsw.gov.au/services/genomics/
  5. European Centre for Disease Prevention and Control (ECDC). Communicable disease threats report, 3-9 March 2024, week 10. Stockholm: ECDC; 8 Mar 2024. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-3-9-march-2024-week-10
  6. Medicines and Healthcare products Regulatory Agency. Urgent Field Safety Notice Product Recall Sodium Chloride Irrigation Solution 0.9% w/v, Sodium Chloride Eye Wash Solution 0.9% w/v, Sodium Chloride Inhalation Solution 0.9% w/v: Legency Remedies Pvt Ltd. London: Medicines and Healthcare products Regulatory Agency; 3 Apr 2024. Available from: https://mhra-gov.filecamp.com/s/d/JfpeDKgndWv9wzP0
  7. Medicines and Healthcare products Regulatory Agency. Device Safety Information: 0.9% Sodium Chloride Solutions for Irrigation, Inhalation, and Eyewash: recall from manufacturer Legency Remedies, DSI/2024/004. London: Medicines and Healthcare products Regulatory Agency; 4 Apr 2024. Available from: https://www.gov.uk/drug-device-alerts/0-dot-9-percent-sodium-chloride-solutions-for-irrigation-inhalation-and-eyewash-recall-from-manufacturer-legency-remedies-dsi-slash-2024-slash-004
  8. Ryan MP, Pembroke JT, Adley CC. Ralstonia pickettii: a persistent gram-negative nosocomial infectious organism. J Hosp Infect. 2006;62(3):278-84.  https://doi.org/10.1016/j.jhin.2005.08.015  PMID: 16337309 
  9. Wu HHL, Collier J, Crosby L, Holder D, Trautt E, Lewis D, et al. Peritoneal dialysis-associated peritonitis presenting with Ralstonia pickettii infection: A novel series of three cases during the COVID-19 pandemic. Semin Dial. 2023;36(1):70-4. https://doi.org/10.1111/sdi.13133  PMID: 36480217 
  10. Labarca JA, Trick WE, Peterson CL, Carson LA, Holt SC, Arduino MJ, et al. A multistate nosocomial outbreak of Ralstonia pickettii colonization associated with an intrinsically contaminated respiratory care solution. Clin Infect Dis. 1999;29(5):1281-6.  https://doi.org/10.1086/313458  PMID: 10524976 
  11. Schnetzinger M, Heger F, Indra A, Kimberger O. Bacterial contamination of water used as thermal transfer fluid in fluid-warming devices. J Hosp Infect. 2023;141:49-54.  https://doi.org/10.1016/j.jhin.2023.06.018  PMID: 37385452 
  12. Viana-Cárdenas E, Triana A, Cárdenas-Álvarez J, Carvajal-Diaz E, Mendoza H, Viasus D. A large multicenter Ralstonia pickettii outbreak in critically ill patients during the COVID-19 pandemic: Epidemiological and clinical characteristics of 66 cases. J Infect Prev. 2024;25(3):85-8.  https://doi.org/10.1177/17571774241236250  PMID: 38584711 
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