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Adapting response to a measles outbreak in a context of high vaccination and breakthrough cases: an example from Vaud, Switzerland, January to March 2024
- Alessandro Cassini1,2,* , Ludovico Cobuccio1,2,* , Emmanouil Glampedakis1 , Pascal Cherpillod3,4,5 , Pierre Alex Crisinel6 , Francisco-Javier Pérez-Rodríguez3,4,5 , Monica Attinger1 , Dominique Bachelin1 , Marie Nahimana Tessemo1 , Mirjam Maeusezahl7 , Céline Gardiol7 , Karim Boubaker1
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View Affiliations Hide AffiliationsAffiliations: 1 Cantonal Doctor Office, Public Health Department, Canton of Vaud, Lausanne, Switzerland 2 Infectious Diseases Service, Lausanne University Hospital, Lausanne, Switzerland 3 Geneva Center for Emerging Viral Diseases, Geneva University Hospitals, Geneva, Switzerland 4 National Measles and Rubella Reference Laboratory, Geneva University Hospitals, Geneva, Switzerland 5 Laboratory of Virology, Laboratory Medicine Division, Geneva University Hospitals, Geneva, Switzerland 6 Unit of paediatric infectious diseases and vaccinology, Service of Paediatrics, Women-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland 7 Communicable Disease Division, Federal Office of Public Health, Bern, Switzerland * These authors contributed equally to this work and share first authorship.Alessandro Cassinialessandro.cassini vd.ch
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Citation style for this article: Cassini Alessandro, Cobuccio Ludovico, Glampedakis Emmanouil, Cherpillod Pascal, Crisinel Pierre Alex, Pérez-Rodríguez Francisco-Javier, Attinger Monica, Bachelin Dominique, Tessemo Marie Nahimana, Maeusezahl Mirjam, Gardiol Céline, Boubaker Karim. Adapting response to a measles outbreak in a context of high vaccination and breakthrough cases: an example from Vaud, Switzerland, January to March 2024. Euro Surveill. 2024;29(22):pii=2400275. https://doi.org/10.2807/1560-7917.ES.2024.29.22.2400275 Received: 08 May 2024; Accepted: 30 May 2024
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Abstract
A measles outbreak with 51 cases occurred in the canton of Vaud, Switzerland, between January and March 2024. The outbreak was triggered by an imported case, and 37 (72.5%) subsequent cases were previously vaccinated individuals. Epidemiological investigations showed that vaccinated measles cases were symptomatic and infectious. In a highly vaccinated population, it is important to raise awareness among healthcare professionals to suspect and test for measles virus when an outbreak is declared, irrespective of the vaccination status of the patients.
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References
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Federal Office of Public Health (FOPH). Bulletin OFSP: Une suisse sans rougeole. [Switzerland without measles]. Bern: FOPH; 1 Dec 2016. French. Available from: https://www.bag.admin.ch/bag/fr/home/strategie-und-politik/nationale-gesundheitsstrategien/nationale-strategie-masernelimination.html
-
Federal Office of Public Health (FOPH). Suivi cantonal de la couverture vaccinale en Suisse. [Cantonal monitoring of vaccination coverage in Switzerland]. Bern: FOPH. [Accessed: 9 Feb 2024]. French. Available from: https://www.bag.admin.ch/bag/fr/home/gesund-leben/gesundheitsfoerderung-und-praevention/impfungen-prophylaxe/informationen-fachleute-gesundheitspersonal/durchimpfung.html
-
Richard JL, Mäusezahl M, Basler S, Eckert N. Approaching measles elimination in Switzerland: changing epidemiology 2007-2018. Swiss Med Wkly. 2019;149:w20102. https://doi.org/10.4414/smw.2019.20102 PMID: 31185128
-
World Health Organization Regional Office for Europe (WHO/Europe). Measles and rubella elimination country profile: Switzerland. Copenhagen: WHO/Europe; 2020. Available from: https://iris.who.int/handle/10665/337743
-
Federal Office of Public Health (FOPH). Directives de lutte contre la rougeole et les flambées de rougeole. Directives et recommandations. [Guidelines for controlling measles and measles outbreaks. Guidelines and recommendations]. Bern: FOPH; 2019. French. Available from: https://www.bag.admin.ch/bag/fr/home/strategie-und-politik/nationale-gesundheitsstrategien/nationale-strategie-masernelimination.html
-
Cherry JD, Zahn M. Clinical characteristics of measles in previously vaccinated and unvaccinated patients in California. Clin Infect Dis. 2018;67(9):1315-9. https://doi.org/10.1093/cid/ciy286 PMID: 29878209
-
López-Perea N, Fernández-García A, Echevarría JE, de Ory F, Pérez-Olmeda M, Masa-Calles J. Measles in vaccinated people: epidemiology and challenges in surveillance and diagnosis in the post-elimination phase. Spain, 2014-2020. Viruses. 2021;13(10):1982. https://doi.org/10.3390/v13101982 PMID: 34696412
-
Risco-Risco C, Masa-Calles J, López-Perea N, Echevarría JE, Rodríguez-Caravaca G. Epidemiology of measles in vaccinated people, Spain 2003-2014. Enferm Infecc Microbiol Clin. 2017;35(9):569-73. https://doi.org/10.1016/j.eimc.2016.05.001 PMID: 27262819
-
Sundell N, Dotevall L, Sansone M, Andersson M, Lindh M, Wahlberg T, et al. Measles outbreak in Gothenburg urban area, Sweden, 2017 to 2018: low viral load in breakthrough infections. Euro Surveill. 2019;24(17):1900114. https://doi.org/10.2807/1560-7917.ES.2019.24.17.1900114 PMID: 31039835
-
Update of the nomenclature for describing the genetic characteristics of wild-type measles viruses: new genotypes and reference strains. Wkly Epidemiol Rec. 2003;78(27):229-32. PMID: 12866261
-
Genetic diversity of wild-type measles viruses and the global measles nucleotide surveillance database (MeaNS). Wkly Epidemiol Rec. 2015;90(30):373-80. PMID: 26211016
-
Benson DA, Cavanaugh M, Clark K, Karsch-Mizrachi I, Lipman DJ, Ostell J, et al. GenBank. Nucleic Acids Res. 2013;41(Database issue):D36-42. PMID: 23193287
-
Orenstein WA, Bernier RH, Dondero TJ, Hinman AR, Marks JS, Bart KJ, et al. Field evaluation of vaccine efficacy. Bull World Health Organ. 1985;63(6):1055-68. PMID: 3879673
-
Kurata T, Yamamoto SP, Nishimura H, Yumisashi T, Motomura K, Kinoshita M. A measles outbreak in Kansai International Airport, Japan, 2016: Analysis of the quantitative difference and infectivity of measles virus between patients who are immunologically naive versus those with secondary vaccine failure. J Med Virol. 2021;93(6):3446-54. https://doi.org/10.1002/jmv.26733 PMID: 33325052
-
Komabayashi K, Seto J, Tanaka S, Suzuki Y, Ikeda T, Onuki N, et al. The largest measles outbreak, including 38 modified measles and 22 typical measles cases in its elimination era in Yamagata, Japan, 2017. Jpn J Infect Dis. 2018;71(6):413-8. https://doi.org/10.7883/yoken.JJID.2018.083 PMID: 29962488
-
Bianchi S, Gori M, Fappani C, Ciceri G, Canuti M, Colzani D, et al. Characterization of vaccine breakthrough cases during measles outbreaks in Milan and surrounding areas, Italy, 2017-2021. Viruses. 2022;14(5):1068. https://doi.org/10.3390/v14051068 PMID: 35632809
-
Hahné SJ, Nic Lochlainn LM, van Burgel ND, Kerkhof J, Sane J, Yap KB, et al. Measles outbreak among previously immunized healthcare workers, the Netherlands, 2014. J Infect Dis. 2016;214(12):1980-6. https://doi.org/10.1093/infdis/jiw480 PMID: 27923955
-
Rota JS, Hickman CJ, Sowers SB, Rota PA, Mercader S, Bellini WJ. Two case studies of modified measles in vaccinated physicians exposed to primary measles cases: high risk of infection but low risk of transmission. J Infect Dis. 2011;204(Suppl 1):S559-63. https://doi.org/10.1093/infdis/jir098 PMID: 21666213
-
Rosen JB, Rota JS, Hickman CJ, Sowers SB, Mercader S, Rota PA, et al. Outbreak of measles among persons with prior evidence of immunity, New York City, 2011. Clin Infect Dis. 2014;58(9):1205-10. https://doi.org/10.1093/cid/ciu105 PMID: 24585562
-
Iwamoto M, Hickman CJ, Colley H, Arciuolo RJ, Mahle CE, Deocharan B, et al. Measles infection in persons with secondary vaccine failure, New York City, 2018-19. Vaccine. 2021;39(38):5346-50. https://doi.org/10.1016/j.vaccine.2021.07.078 PMID: 34393016
-
Zhang Z, Chen M, Ma R, Pan J, Suo L, Lu L. Outbreak of measles among persons with secondary vaccine failure, China, 2018. Hum Vaccin Immunother. 2020;16(2):358-62. https://doi.org/10.1080/21645515.2019.1653742 PMID: 31487215
-
Orenstein W, Offit P, Edwards K, Plotkin S. Plotkin's Vaccines. 8th Edition. Amsterdam: Elsevier; 2022. p. 1808
-
World Health Organization. Measles vaccines: WHO position paper, April 2017 - recommendations. Vaccine. 2019;37(2):219-22. https://doi.org/10.1016/j.vaccine.2017.07.066 PMID: 28760612
-
Ministère du Travail, de la Santé et des Solidarités (Santé). Recommandations sanitaires dans le cadre de l’épidémie de rougeole touchant l’Ardèche et la Drôme depuis septembre 2023. [Health recommendations on the measles outbreak affecting Ardèche et Drôme since September 2023]. Paris: Santé; 16 Nov 2023. French. Available from: https://sante.gouv.fr/IMG/pdf/dgs-urgent_n02023_21_rougeole_ara.pdf
-
Nic Lochlainn LM, de Gier B, van der Maas N, van Binnendijk R, Strebel PM, Goodman T, et al. Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis. Lancet Infect Dis. 2019;19(11):1246-54. https://doi.org/10.1016/S1473-3099(19)30396-2 PMID: 31548081
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