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SDG 3: Antimicrobial resistance

Abstract

Fosfomycin-resistant FosA8-producing are uncommon strains with extremely low incidence in Europe, based on only three reports in the literature. We detected FosA8-producing ST131 in clinical isolates from two patients admitted in February 2023 to a rehabilitation unit in Italy. The occurrence of rare -like genes in the high-risk clone ST131 is of clinical relevance. The dissemination of FosA-producing although still at low levels, should be continuously monitored.

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/content/10.2807/1560-7917.ES.2024.29.21.2400276
2024-05-23
2024-12-21
/content/10.2807/1560-7917.ES.2024.29.21.2400276
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References

  1. Falagas ME, Athanasaki F, Voulgaris GL, Triarides NA, Vardakas KZ. Resistance to fosfomycin: mechanisms, frequency and clinical consequences. Int J Antimicrob Agents. 2019;53(1):22-8.  https://doi.org/10.1016/j.ijantimicag.2018.09.013  PMID: 30268576 
  2. Mattioni Marchetti V, Hrabak J, Bitar I. Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat. Front Cell Infect Microbiol. 2023;13:1178547.  https://doi.org/10.3389/fcimb.2023.1178547  PMID: 37469601 
  3. European Committee on Antimicrobial Susceptibility Testing (EUCAST). The 13.0 versions of breakpoints, dosing and QC (2023) published. Växjö: EUCAST; 2023. Available from: https://www.eucast.org/eucast_news/news_singleview?tx_ttnews%5Btt_news%5D=518&cHash=2509b0db92646dffba041406dcc9f20c
  4. Mattioni Marchetti V, Kraftova L, Finianos M, Sourenian T, Hrabak J, Bitar I. Polyclonal spread of fosfomycin resistance among carbapenemase-producing members of the Enterobacterales in the Czech Republic. Microbiol Spectr. 2023;11(3):e0009523.  https://doi.org/10.1128/spectrum.00095-23  PMID: 37098942 
  5. Carattoli A, Zankari E, Garcia-Fernandez A, Volby Larsen M, Lund O, Villa L, et al. PlasmidFinder and pMLST: in silico detection and typing of plasmids. Antimicrob Agents Chemother. 2014;58(7):3895-903.  https://doi.org/10.1128/AAC.02412-14  PMID: 24777092 
  6. Poirel L, Vuillemin X, Kieffer N, Mueller L, Descombes MC, Nordmann P. Identification of FosA8, a plasmid-encoded fosfomycin resistance determinant from Escherichia coli, and its origin in Leclercia adecarboxylata. Antimicrob Agents Chemother. 2019;63(11):e01403-19.  https://doi.org/10.1128/AAC.01403-19  PMID: 31481445 
  7. Piazza A, Corbella M, Mattioni Marchetti V, Merla C, Mileto I, Kuka A, et al. Clinical isolates of ST131 blaOXA-244-positive Escherichia coli, Italy, December 2022 to July 2023. Euro Surveill. 2024;29(8):2400073.  https://doi.org/10.2807/1560-7917.ES.2024.29.8.2400073  PMID: 38390649 
  8. Tanrıverdi Çaycı Y, Hacıeminoğlu Ülker K, Karacan Temür G, Güney DB, Ertokatlı M, Birinci A. Escherichia coli İzolatlarında O25b-ST131 Klonu Sıklığı ile Karbapenem ve Fosfomisin Direnç Genlerinin Varlığının Araştırılması: Escherichia coli O25b-ST131 İzolatlarında Türkiye’den İlk fosA3 Tespiti. [Investigation of O25b-ST131 Clone Frequency and Presence of Carbapenem and Fosfomycin Resistance Genes in Escherichia coli Isolates: First Detection of fosA3 from Escherichia coli O25bSTf131 Clone from Türkiye]. Mikrobiyol Bul. 2023;57(3):454-62. Turkish.  https://doi.org/10.5578/mb.20239937  PMID: 37462308 
  9. Shi J, Zhu H, Liu C, Xie H, Li C, Cao X, et al. Epidemiological and genomic characteristics of global mcr-positive Escherichia coli isolates. Front Microbiol. 2023;13:1105401.  https://doi.org/10.3389/fmicb.2022.1105401  PMID: 36741897 
  10. Hameed MF, Chen Y, Bilal H, Khan S, Ge H, Xiaofang C, et al. The Co-occurrence of mcr-3 and fosA3 in IncP plasmid in ST131 Escherichia coli: A novel case. J Infect Dev Ctries. 2022;16(4):622-9.  https://doi.org/10.3855/jidc.15943  PMID: 35544623 
  11. Milner KA, Bay DC, Alexander D, Walkty A, Karlowsky JA, Mulvey MR, et al. Identification and characterization of a novel FosA7 Member from fosfomycin-resistant Escherichia coli clinical isolates from Canadian hospitals. Antimicrob Agents Chemother. 2020;65(1):e00865-20.  https://doi.org/10.1128/AAC.00865-20  PMID: 33077665 
  12. Findlay J, Sierra R, Raro OHF, Aires-de-Sousa M, Andrey DO, Nordmann P. Plasmid-mediated fosfomycin resistance in Escherichia coli isolates of worldwide origin. J Glob Antimicrob Resist. 2023;35:137-42.  https://doi.org/10.1016/j.jgar.2023.09.003  PMID: 37709135 
  13. Sullivan MJ, Petty NK, Beatson SA. Easyfig: a genome comparison visualizer. Bioinformatics. 2011;27(7):1009-10.  https://doi.org/10.1093/bioinformatics/btr039 
FosA8-producing E. coli ST131: clinical cases in Italy, February 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Katerina+Chudejova&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chudejova Katerina</a>, <a href="/search?value1=Maria+Sofia+Caltagirone&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caltagirone Maria Sofia</a>, <a href="/search?value1=Vittoria+Mattioni+Marchetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mattioni Marchetti Vittoria</a>, <a href="/search?value1=Antonella+Rezzani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rezzani Antonella</a>, <a href="/search?value1=Antonella+Navarra&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Navarra Antonella</a>, <a href="/search?value1=Ibrahim+Bitar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bitar Ibrahim</a></span>. FosA8-producing E. coli ST131: clinical cases in Italy, February 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(21):pii=2400276. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.21.2400276" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.21.2400276</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 May 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 23 May 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.21.2400276
/content/10.2807/1560-7917.ES.2024.29.21.2400276
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