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SDG 3: Antimicrobial resistance

Abstract

Background

Antimicrobial resistance to mupirocin and fusidic acid, which are used for treatment of skin infections caused by is of concern.

Aim

To investigate resistance to fusidic acid and mupirocin in meticillin-susceptible (MSSA) from community-acquired skin and soft tissue infections (SSTIs) in Belgium.

Methods

We collected 2013–2023 data on fusidic acid and mupirocin resistance in SSTI-associated MSSA from two large Belgian laboratories. Resistant MSSA isolates sent to the Belgian Reference Centre were -typed and analysed for the presence of the and virulence genes and the resistance gene. In addition, we whole genome sequenced MSSA isolates collected between October 2021 and September 2023.

Results

Mupirocin resistance increased between 2013 and 2023 from 0.5-1.5% to 1.7-5.6%. Between 2018 and 2023, 91.4% (64/70) of mupirocin-resistant isolates were co-resistant to fusidic acid. By September 2023, between 8.9% (15/168) and 10.1% (11/109) of children isolates from the two laboratories were co-resistant. Of the 33 sequenced isolates, 29 were sequence type 121, clonal and more distantly related to the European epidemic fusidic acid-resistant impetigo clone (EEFIC) observed in Belgium in 2020. These isolates carried the and genes conferring resistance to mupirocin and fusidic acid, respectively, and the and virulence genes.

Conclusion

We highlight the spread of a mupirocin-resistant EEFIC in children, with a seasonal trend for the third quarter of the year. This is of concern because this variant is resistant to the two main topical antibiotics used to treat impetigo in Belgium.

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2024-05-09
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2024.29.19.2300668
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Emergence and spread of a mupirocin-resistant variant of the European epidemic fusidic acid-resistant impetigo clone of Staphylococcus aureus, Belgium, 2013 to 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Nicolas+Yin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yin Nicolas</a>, <a href="/search?value1=Charlotte+Michel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Michel Charlotte</a>, <a href="/search?value1=Nadia+Makki&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Makki Nadia</a>, <a href="/search?value1=Ariane+Deplano&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deplano Ariane</a>, <a href="/search?value1=Alisha+Milis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Milis Alisha</a>, <a href="/search?value1=Benoit+Prevost&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Prevost Benoit</a>, <a href="/search?value1=Veronique+Yvette+Miendje-Deyi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Miendje-Deyi Veronique Yvette</a>, <a href="/search?value1=Marie+Hallin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hallin Marie</a>, <a href="/search?value1=Delphine+Martiny&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Martiny Delphine</a></span>. Emergence and spread of a mupirocin-resistant variant of the European epidemic fusidic acid-resistant impetigo clone of Staphylococcus aureus, Belgium, 2013 to 2023. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(19):pii=2300668. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.19.2300668" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.19.2300668</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 24 Nov 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 11 Mar 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.19.2300668
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