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Abstract

A severe outbreak of influenza A(H1N1pdm09) infection in seven children (median age: 52 months) occurred between December 2023 and January 2024 in Tuscany, Italy. Clinical presentation ranged from milder encephalopathy to acute necrotizing encephalopathy (ANE) with coma and multiorgan failure; one child died. This report raises awareness for clinicians to identify and treat early acute encephalopathy caused by H1N1 influenza and serves as a reminder of severe presentations of influenza in young children and the importance of vaccination.

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/content/10.2807/1560-7917.ES.2024.29.17.2400199
2024-04-25
2024-12-22
/content/10.2807/1560-7917.ES.2024.29.17.2400199
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Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Luca+Bartolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bartolini Luca</a>, <a href="/search?value1=Silvia+Ricci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ricci Silvia</a>, <a href="/search?value1=Chiara+Azzari&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Azzari Chiara</a>, <a href="/search?value1=Maria+Moriondo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Moriondo Maria</a>, <a href="/search?value1=Francesco+Nieddu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nieddu Francesco</a>, <a href="/search?value1=Manuela+L%E2%80%99Erario&option1=author&noRedirect=true" class="nonDisambigAuthorLink">L’Erario Manuela</a>, <a href="/search?value1=Zaccaria+Ricci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ricci Zaccaria</a>, <a href="/search?value1=Gabriele+Simonini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Simonini Gabriele</a>, <a href="/search?value1=Marzia+Mortilla&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mortilla Marzia</a>, <a href="/search?value1=Giuseppe+Indolfi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Indolfi Giuseppe</a>, <a href="/search?value1=Carlotta+Montagnani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Montagnani Carlotta</a>, <a href="/search?value1=Elena+Chiappini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chiappini Elena</a>, <a href="/search?value1=Luisa+Galli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Galli Luisa</a>, <a href="/search?value1=Renzo+Guerrini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guerrini Renzo</a></span>. Severe A(H1N1)pdm09 influenza acute encephalopathy outbreak in children in Tuscany, Italy, December 2023 to January 2024. <a href="/content/ecdc">Euro Surveill.</a> 2024;29(17):pii=2400199. <a href="https://doi.org/10.2807/1560-7917.ES.2024.29.17.2400199" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2024.29.17.2400199</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 01 Apr 2024;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Apr 2024 </span> </p>
/content/10.2807/1560-7917.ES.2024.29.17.2400199
/content/10.2807/1560-7917.ES.2024.29.17.2400199
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