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Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023
- Stephen B Beres1 , Randall J Olsen1,2 , S Wesley Long1,2 , Ross Langley3 , Thomas Williams4 , Helga Erlendsdottir5,6 , Andrew Smith7,8 , Karl G Kristinsson5,6 , James M Musser1,2
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View Affiliations Hide AffiliationsAffiliations: 1 Laboratory of Molecular and Translational Human Infectious Disease Research, Center for Infectious Diseases, Department of Pathology and Genomic Medicine, Houston Methodist Research Institute and Houston Methodist Hospital, Houston, United States 2 Departments of Pathology and Laboratory Medicine and Microbiology and Immunology, Weill Cornell Medical College, New York, United States 3 Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children, Glasgow, Scotland 4 Department of Child Life and Health, University of Edinburgh, Edinburgh, Scotland 5 Department of Clinical Microbiology, Landspitali – the National University Hospital of Iceland, Reykjavik, Iceland 6 Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland 7 College of Medical, Veterinary and Life Sciences, Glasgow Dental Hospital and School, University of Glasgow, Glasgow, Scotland 8 Scottish Microbiology Reference Laboratory, New Lister Building, Glasgow, ScotlandJames M MusserJMMusser houstonmethodist.org
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Citation style for this article: Beres Stephen B, Olsen Randall J, Long S Wesley, Langley Ross, Williams Thomas, Erlendsdottir Helga, Smith Andrew, Kristinsson Karl G, Musser James M. Increase in invasive Streptococcus pyogenes M1 infections with close evolutionary genetic relationship, Iceland and Scotland, 2022 to 2023. Euro Surveill. 2024;29(13):pii=2400129. https://doi.org/10.2807/1560-7917.ES.2024.29.13.2400129 Received: 26 Feb 2024; Accepted: 27 Mar 2024
Abstract
Group A Streptococcus isolates of the recently described M1UK clade have emerged to cause human infections in several European countries and elsewhere. Full-genome sequence analysis of M1 isolates discovered a close genomic relationship between some isolates from Scotland and the majority of isolates from Iceland causing serious infections in 2022 and 2023. Phylogenetic analysis strongly suggests that an isolate from or related to Scotland was the precursor to an M1UK variant responsible for almost all recent M1 infections in Iceland.
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