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Abstract

Background

The COVID-19 pandemic resulted in adaptation in infection control measures, increased patient transfer, high occupancy of intensive cares, downscaling of non-urgent medical procedures and decreased travelling.

Aim

To gain insight in the influence of these changes on antimicrobial resistance (AMR) prevalence in the Netherlands, a country with a low AMR prevalence, we estimated changes in demographics and prevalence of six highly resistant microorganisms (HRMO) in hospitalised patients in the Netherlands during COVID-19 waves (March–June 2020, October 2020–June 2021, October 2021–May 2022 and June–August 2022) and interwaves (July–September 2020 and July–September 2021) compared with pre-COVID-19 (March 2019–February 2020).

Methods

We investigated data on routine bacteriology cultures of hospitalised patients, obtained from 37 clinical microbiological laboratories participating in the national AMR surveillance. Demographic characteristics and HRMO prevalence were calculated as proportions and rates per 10,000 hospital admissions.

Results

Although no significant persistent changes in HRMO prevalence were detected, some relevant non-significant patterns were recognised in intensive care units. Compared with pre-COVID-19 we found a tendency towards higher prevalence of meticillin-resistant during waves and lower prevalence of multidrug-resistant during interwaves. Additionally, during the first three waves, we observed significantly higher proportions and rates of cultures with (pooled 10% vs 6% and 240 vs 120 per 10,000 admissions) and coagulase-negative Staphylococci (pooled 21% vs 14% and 500 vs 252 per 10,000 admissions) compared with pre-COVID-19.

Conclusion

We observed no substantial changes in HRMO prevalence in hospitalised patients during the COVID-19 pandemic.

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This work is licensed under a Creative Commons Attribution 4.0 International License.
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2023-12-14
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.50.2300152
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Impact of the COVID-19 pandemic on prevalence of highly resistant microorganisms in hospitalised patients in the Netherlands, March 2020 to August 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Wieke+Altorf-van+der+Kuil&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Altorf-van der Kuil Wieke</a>, <a href="/search?value1=Cornelia+CH+Wielders&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wielders Cornelia CH</a>, <a href="/search?value1=Romy+D+Zwittink&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zwittink Romy D</a>, <a href="/search?value1=Sabine+C+de+Greeff&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Greeff Sabine C</a>, <a href="/search?value1=Dave+A+Dongelmans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dongelmans Dave A</a>, <a href="/search?value1=Ed+J+Kuijper&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kuijper Ed J</a>, <a href="/search?value1=Daan+W+Notermans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Notermans Daan W</a>, <a href="/search?value1=Annelot+F+Schoffelen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schoffelen Annelot F</a>, <a href="/search?value1=on+behalf+of+the+study+collaborators+ISIS-AR+study+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the study collaborators ISIS-AR study group</a></span>. Impact of the COVID-19 pandemic on prevalence of highly resistant microorganisms in hospitalised patients in the Netherlands, March 2020 to August 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(50):pii=2300152. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.50.2300152" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.50.2300152</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 08 Mar 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 28 Jun 2023 </span> </p>
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