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Abstract

An outbreak of bloodstream infections occurred in four hospitals in north-eastern Italy, involving 20 haemodialysis patients with tunnelled central vascular catheter access. We identified as the outbreak source a batch of urokinase vials imported from India contaminated with Whole genome sequences of the clinical and urokinase strains were highly related, and only urokinase-treated patients were reported with infections (attack rate = 34%; 95% confidence interval: 22.1–47.4). Discontinuation of the contaminated urokinase terminated the outbreak.

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/content/10.2807/1560-7917.ES.2023.28.28.2300328
2023-07-13
2024-12-16
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.28.2300328
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A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Massimiliano+Fabricci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fabricci Massimiliano</a>, <a href="/search?value1=Ana%C3%AFs+Trinca&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trinca Anaïs</a>, <a href="/search?value1=Luca+Talotti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Talotti Luca</a>, <a href="/search?value1=Marina+Busetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Busetti Marina</a>, <a href="/search?value1=Emmanouil+Alexandros+Fotakis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fotakis Emmanouil Alexandros</a>, <a href="/search?value1=Christina+Merakou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Merakou Christina</a>, <a href="/search?value1=Raffaella+Koncan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koncan Raffaella</a>, <a href="/search?value1=Annachiara+Ghiotti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ghiotti Annachiara</a>, <a href="/search?value1=Camilla+Negri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Negri Camilla</a>, <a href="/search?value1=Vittorio+Di+Maso&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Di Maso Vittorio</a>, <a href="/search?value1=Manuela+Bosco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bosco Manuela</a>, <a href="/search?value1=Alberto+Antonelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Antonelli Alberto</a>, <a href="/search?value1=Marco+Coppi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Coppi Marco</a>, <a href="/search?value1=Gian+Maria+Rossolini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rossolini Gian Maria</a>, <a href="/search?value1=Claudia+Giuliani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giuliani Claudia</a>, <a href="/search?value1=Enrico+Scarpis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Scarpis Enrico</a>, <a href="/search?value1=Barbara+Gregoretti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gregoretti Barbara</a>, <a href="/search?value1=Danilo+Licastro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Licastro Danilo</a>, <a href="/search?value1=Roberto+Luzzati&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Luzzati Roberto</a>, <a href="/search?value1=Venera+Costantino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Costantino Venera</a>, <a href="/search?value1=the+multidisciplinary+working+group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">the multidisciplinary working group</a></span>. A urokinase-associated outbreak of Ralstonia mannitolilytica bloodstream infections in haemodialysis patients in north-eastern Italy, January to April 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(28):pii=2300328. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.28.2300328" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.28.2300328</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 28 Jun 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 13 Jul 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.28.2300328
/content/10.2807/1560-7917.ES.2023.28.28.2300328
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