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Abstract

Infections with OXA-244-carbapenemase-producing with sequence type (ST)38 have recently increased in Europe. Due to its low-level activity against carbapenems, OXA-244 can be difficult to detect. Previous assessments have not revealed a clear source and route of transmission for OXA-244-producing , but there are indications of non-healthcare related sources and community spread. Here we report a hospital-associated outbreak of OXA-244-producing ST38 involving three hospitals in Western Norway in 2020. The outbreak occurred over a 5-month period and included 12 cases identified through clinical (n = 6) and screening (n = 6) samples. The transmission chain was unclear; cases were identified in several wards and there was no clear overlap of patient stay. However, all patients had been admitted to the same tertiary hospital in the region, where screening revealed an outbreak in one ward (one clinical case and five screening cases). Outbreak control measures were instigated including contact tracing, isolation, and screening; no further cases were identified in 2021. This outbreak adds another dimension to the spread of OXA-244-producing ST38, illustrating this clone’s ability to establish itself in the healthcare setting. Awareness of challenges concerning OXA-244-producing diagnostic is important to prevent further spread.

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/content/10.2807/1560-7917.ES.2023.28.27.2200773
2023-07-06
2024-11-22
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.27.2200773
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Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Paul+Christoffer+Lindemann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lindemann Paul Christoffer</a>, <a href="/search?value1=Torunn+Pedersen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pedersen Torunn</a>, <a href="/search?value1=Dorthea+Hagen+Oma&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oma Dorthea Hagen</a>, <a href="/search?value1=Jessin+Janice&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Janice Jessin</a>, <a href="/search?value1=Fredrik+Gr%C3%B8van&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grøvan Fredrik</a>, <a href="/search?value1=Ghantous+Milad+Chedid&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chedid Ghantous Milad</a>, <a href="/search?value1=Liv+Jorunn+Hafne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hafne Liv Jorunn</a>, <a href="/search?value1=Ellen+H.+Josefsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Josefsen Ellen H.</a>, <a href="/search?value1=Oliver+Kacelnik&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kacelnik Oliver</a>, <a href="/search?value1=Arnfinn+Sundsfjord&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sundsfjord Arnfinn</a>, <a href="/search?value1=%C3%98rjan+Samuelsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Samuelsen Ørjan</a></span>. Intraregional hospital outbreak of OXA-244-producing Escherichia coli ST38 in Norway, 2020. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(27):pii=2200773. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.27.2200773" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.27.2200773</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 29 Sept 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 09 May 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.27.2200773
/content/10.2807/1560-7917.ES.2023.28.27.2200773
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