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Abstract

A highly virulent sub-lineage of the M1 clone has been rapidly expanding throughout Denmark since late 2022 and now accounts for 30% of the new invasive group A streptococcal infections. We aimed to investigate whether a shift in variant composition can account for the high incidence rates observed over winter 2022/23, or if these are better explained by the impact of COVID-19-related restrictions on population immunity and carriage of group A .

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/content/10.2807/1560-7917.ES.2023.28.26.2300291
2023-06-29
2024-12-18
/content/10.2807/1560-7917.ES.2023.28.26.2300291
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Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Thor+Bech+Johannesen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Johannesen Thor Bech</a>, <a href="/search?value1=Charlotte++Munkstrup&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Munkstrup Charlotte </a>, <a href="/search?value1=Sofie+Marie+Edslev&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Edslev Sofie Marie</a>, <a href="/search?value1=Sharmin+Baig&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Baig Sharmin</a>, <a href="/search?value1=Stine+Nielsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nielsen Stine</a>, <a href="/search?value1=Tjede+Funk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Funk Tjede</a>, <a href="/search?value1=Dennis+Karsten+Kristensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kristensen Dennis Karsten</a>, <a href="/search?value1=Lars+Hervig+Jacobsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jacobsen Lars Hervig</a>, <a href="/search?value1=Signe+Fischer+Ravn&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ravn Signe Fischer</a>, <a href="/search?value1=Niels+Bindslev&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bindslev Niels</a>, <a href="/search?value1=Sophie+Gubbels&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gubbels Sophie</a>, <a href="/search?value1=Marianne+Voldstedlund&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Voldstedlund Marianne</a>, <a href="/search?value1=Pikka+Jokelainen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jokelainen Pikka</a>, <a href="/search?value1=S%C3%B8ren+Hallstr%C3%B8m&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hallstrøm Søren</a>, <a href="/search?value1=Astrid+Rasmussen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rasmussen Astrid</a>, <a href="/search?value1=Karl+G%C3%BAstaf+Kristinsson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kristinsson Karl Gústaf</a>, <a href="/search?value1=David+Fuglsang-Damgaard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fuglsang-Damgaard David</a>, <a href="/search?value1=Ram+B+Dessau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dessau Ram B</a>, <a href="/search?value1=Agnieszka+Barbara+Ols%C3%A9n&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Olsén Agnieszka Barbara</a>, <a href="/search?value1=Christian+Salgaard+Jensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jensen Christian Salgaard</a>, <a href="/search?value1=Annette+Skovby&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Skovby Annette</a>, <a href="/search?value1=Svend+Ellermann-Eriksen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ellermann-Eriksen Svend</a>, <a href="/search?value1=Th%C3%B8ger+Gorm+Jensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jensen Thøger Gorm</a>, <a href="/search?value1=Esad+Dzajic&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dzajic Esad</a>, <a href="/search?value1=Claus+%C3%98stergaard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Østergaard Claus</a>, <a href="/search?value1=Steen++Lomborg+Andersen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lomborg Andersen Steen </a>, <a href="/search?value1=Steen+Hoffmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoffmann Steen</a>, <a href="/search?value1=Peter+Henrik+Andersen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andersen Peter Henrik</a>, <a href="/search?value1=Marc+Stegger&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stegger Marc</a></span>. Increase in invasive group A streptococcal infections and emergence of novel, rapidly expanding sub-lineage of the virulent Streptococcus pyogenes M1 clone, Denmark, 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(26):pii=2300291. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.26.2300291" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.26.2300291</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 08 Jun 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Jun 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.26.2300291
/content/10.2807/1560-7917.ES.2023.28.26.2300291
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