Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Mathilde Grapin; Audrey Mirand; Didier Pinquier; Aurélie Basset; Matthieu Bendavid; Maxime Bisseux; Marion Jeannoël; Bérengère Kireche; Manoelle Kossorotoff; Anne-Sophie L’Honneur; Lila Robin; Yves Ville; Sylvain Renolleau; Véronique Lemee; Pierre-Henri Jarreau; Isabelle Desguerre; Florence Lacaille; Marianne Leruez-Ville; Clémence Guillaume; Cécile Henquell; Alexandre Lapillonne; Isabelle Schuffenecker; Mélodie Aubart

doi:10.2807/1560-7917.ES.2023.28.22.2300253

Rapid communication Open Access

Like 0

Download

Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023
Mathilde Grapin^1,* , Audrey Mirand^2,3,* , Didier Pinquier⁴ , Aurélie Basset⁵ , Matthieu Bendavid¹ , Maxime Bisseux^2,3 , Marion Jeannoël⁶ , Bérengère Kireche⁷ , Manoelle Kossorotoff⁸ , Anne-Sophie L’Honneur⁹ , Lila Robin⁷ , Yves Ville¹⁰ , Sylvain Renolleau¹ , Véronique Lemee¹¹ , Pierre-Henri Jarreau⁵ , Isabelle Desguerre⁸ , Florence Lacaille¹² , Marianne Leruez-Ville¹³ , Clémence Guillaume¹⁴ , Cécile Henquell^2,3 , Alexandre Lapillonne¹⁵ , Isabelle Schuffenecker^6,** , Mélodie Aubart^8,16,**
View Affiliations Hide Affiliations

Affiliations: ¹ Paediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ² Clermont-Ferrand University Hospital, 3IHP - Infection Inflammation et Interaction Hôtes Pathogènes Virology Department, French Reference Centre for enteroviruses and parechovirus, coordination laboratory, Clermont-Ferrand, France ³ Auvergne University, LMGE UMR CNRS 6023, Team Epidemiology and pathophysiology of enterovirus Infection, Clermont-Ferrand, France ⁴ Neonatal and Paediatric Intensive Care Units, Rouen University Hospital, Rouen, France ⁵ Neonatal Intensive Care Unit, Cochin-Port Royal University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ⁶ Hospices Civils de Lyon, Virology Department, French Reference Centre for enteroviruses and parechoviruses, associated laboratory, Lyon, France ⁷ Neonatal and Paediatric Intensive Care Units, Orléans Regional Hospital, Orléans, France ⁸ Paediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ⁹ Virology laboratory, Cochin University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹⁰ Obstetrics and Fetal Medicine Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹¹ Virology Department, Rouen University Hospital, Rouen, France ¹² Pediatric Gastroenterology-Hepatology-Nutrition Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, University of Paris, Paris, France ¹³ Clinical Microbiology laboratory and Virology unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹⁴ Orléans Hospital, Microbiology laboratory, Orléans, France ¹⁵ Neonatal Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹⁶ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Institut National de la Santé et de la Recherche Médicale U1163, Paris, France ^* These authors contributed equally to the work and share the first authorship. ^** These authors contributed equally to the work and share the last authorship.

Correspondence:
Mélodie AUBART
melodie.aubart aphp.fr
View Citation Hide Citation

Citation style for this article: Grapin Mathilde, Mirand Audrey, Pinquier Didier, Basset Aurélie, Bendavid Matthieu, Bisseux Maxime, Jeannoël Marion, Kireche Bérengère, Kossorotoff Manoelle, L’Honneur Anne-Sophie, Robin Lila, Ville Yves, Renolleau Sylvain, Lemee Véronique, Jarreau Pierre-Henri, Desguerre Isabelle, Lacaille Florence, Leruez-Ville Marianne, Guillaume Clémence, Henquell Cécile, Lapillonne Alexandre, Schuffenecker Isabelle, Aubart Mélodie. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023. Euro Surveill. 2023;28(22):pii=2300253. https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253 Received: 17 May 2023; Accepted: 01 Jun 2023

Previous Article
Table of Contents
Next Article

Abstract

We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3–5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted.

This work is licensed under a Creative Commons Attribution 4.0 International License.

Article metrics loading...

/content/10.2807/1560-7917.ES.2023.28.22.2300253

2023-06-01

2024-12-21

Click here for cited by

/content/10.2807/1560-7917.ES.2023.28.22.2300253

Full text loading...

/deliver/fulltext/eurosurveillance/28/22/eurosurv-28-22-1.html?itemId=/content/10.2807/1560-7917.ES.2023.28.22.2300253&mimeType=html&fmt=ahah

References

Abzug MJ. Presentation, diagnosis, and management of enterovirus infections in neonates. Paediatr Drugs. 2004;6(1):1-10. https://doi.org/10.2165/00148581-200406010-00001 PMID: 14969566
Sandoni M, Ciardo L, Tamburini C, Boncompagni A, Rossi C, Guidotti I, et al. Enteroviral Infections in the first three months of life. Pathogens. 2022;11(1):60. https://doi.org/10.3390/pathogens11010060 PMID: 35056008
Chuang YY, Huang YC. Enteroviral infection in neonates. J Microbiol Immunol Infect. 2019;52(6):851-7. https://doi.org/10.1016/j.jmii.2019.08.018 PMID: 31607572
Duval M, Mirand A, Lesens O, Bay JO, Caillaud D, Gallot D, et al. Retrospective study of the upsurge of enterovirus D68 clade D1 among adults (2014-2018). Viruses. 2021;13(8):1607. https://doi.org/10.3390/v13081607 PMID: 34452471
Mirand A, le Sage FV, Pereira B, Cohen R, Levy C, Archimbaud C, et al. Ambulatory pediatric surveillance of hand, foot and mouth disease as signal of an outbreak of coxsackievirus A6 infections, France, 2014-2015. Emerg Infect Dis. 2016;22(11):1884-93. https://doi.org/10.3201/eid2211.160590 PMID: 27767012
Nix WA, Oberste MS, Pallansch MA. Sensitive, seminested PCR amplification of VP1 sequences for direct identification of all enterovirus serotypes from original clinical specimens. J Clin Microbiol. 2006;44(8):2698-704. https://doi.org/10.1128/JCM.00542-06 PMID: 16891480
Schuffenecker I, Mirand A, Josset L, Henquell C, Hecquet D, Pilorgé L, et al. Epidemiological and clinical characteristics of patients infected with enterovirus D68, France, July to December 2014. Euro Surveill. 2016;21(19):30226. https://doi.org/10.2807/1560-7917.ES.2016.21.19.30226 PMID: 27195770
French Reference Centre for enteroviruses and parechovirus. CNR enterovirus. Clermont-Ferrand-Lyon: France. [Accessed: 6 May 2023]. Available from: http://cnr.chu-clermontferrand.fr/CNR
European Centre for Disease Prevention and Control (ECDC). Weekly bulletin. Communicable Disease Threats Report. Week 18, 30 April–6 May 2023. Stockholm: ECDC; 2023. Available from: https://www.ecdc.europa.eu/en/publications-data/communicable-disease-threats-report-30-april-6-may-2023-week-18
Khetsuriani N, Lamonte A, Oberste MS, Pallansch M. Neonatal enterovirus infections reported to the national enterovirus surveillance system in the United States, 1983-2003. Pediatr Infect Dis J. 2006;25(10):889-93. https://doi.org/10.1097/01.inf.0000237798.07462.32 PMID: 17006282
Zhang M, Wang H, Tang J, He Y, Xiong T, Li W, et al. Clinical characteristics of severe neonatal enterovirus infection: a systematic review. BMC Pediatr. 2021;21(1):127. https://doi.org/10.1186/s12887-021-02599-y PMID: 33722228
Chen J, Jing H, Martin-Nalda A, Bastard P, Rivière JG, Liu Z, et al. Inborn errors of TLR3- or MDA5-dependent type I IFN immunity in children with enterovirus rhombencephalitis. J Exp Med. 2021;218(12):e20211349. https://doi.org/10.1084/jem.20211349 PMID: 34726731
Yen MH, Huang YC, Chen MC, Liu CC, Chiu NC, Lien R, et al. Effect of intravenous immunoglobulin for neonates with severe enteroviral infections with emphasis on the timing of administration. J Clin Virol. 2015;64:92-6. https://doi.org/10.1016/j.jcv.2015.01.013 PMID: 25728086
Abzug MJ, Michaels MG, Wald E, Jacobs RF, Romero JR, Sánchez PJ, et al. . A Randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis. J Pediatric Infect Dis Soc. 2016;5(1):53-62. https://doi.org/10.1093/jpids/piv015 PMID: 26407253
Torres-Torres S, Myers AL, Klatte JM, Rhoden EE, Oberste MS, Collett MS, et al. First use of investigational antiviral drug pocapavir (v-073) for treating neonatal enteroviral sepsis. Pediatr Infect Dis J. 2015;34(1):52-4. https://doi.org/10.1097/INF.0000000000000497 PMID: 25229269

Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Citation style for this article: <a href="/search?value1=Mathilde+Grapin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grapin Mathilde</a>, <a href="/search?value1=Audrey+Mirand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mirand Audrey</a>, <a href="/search?value1=Didier+Pinquier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pinquier Didier</a>, <a href="/search?value1=Aur%C3%A9lie+Basset&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Basset Aurélie</a>, <a href="/search?value1=Matthieu+Bendavid&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bendavid Matthieu</a>, <a href="/search?value1=Maxime+Bisseux&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bisseux Maxime</a>, <a href="/search?value1=Marion+Jeanno%C3%ABl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jeannoël Marion</a>, <a href="/search?value1=B%C3%A9reng%C3%A8re+Kireche&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kireche Bérengère</a>, <a href="/search?value1=Manoelle+Kossorotoff&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kossorotoff Manoelle</a>, <a href="/search?value1=Anne-Sophie+L%E2%80%99Honneur&option1=author&noRedirect=true" class="nonDisambigAuthorLink">L’Honneur Anne-Sophie</a>, <a href="/search?value1=Lila+Robin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robin Lila</a>, <a href="/search?value1=Yves+Ville&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ville Yves</a>, <a href="/search?value1=Sylvain+Renolleau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Renolleau Sylvain</a>, <a href="/search?value1=V%C3%A9ronique+Lemee&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lemee Véronique</a>, <a href="/search?value1=Pierre-Henri+Jarreau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jarreau Pierre-Henri</a>, <a href="/search?value1=Isabelle+Desguerre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Desguerre Isabelle</a>, <a href="/search?value1=Florence+Lacaille&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lacaille Florence</a>, <a href="/search?value1=Marianne+Leruez-Ville&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leruez-Ville Marianne</a>, <a href="/search?value1=Cl%C3%A9mence+Guillaume&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guillaume Clémence</a>, <a href="/search?value1=C%C3%A9cile+Henquell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Henquell Cécile</a>, <a href="/search?value1=Alexandre+Lapillonne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lapillonne Alexandre</a>, <a href="/search?value1=Isabelle+Schuffenecker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schuffenecker Isabelle</a>, <a href="/search?value1=M%C3%A9lodie+Aubart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aubart Mélodie</a>. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(22):pii=2300253. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253</a> Received: 17 May 2023;   Accepted: 01 Jun 2023

/content/10.2807/1560-7917.ES.2023.28.22.2300253

Data & Media loading...

Supplementary data

Download
- Supplementary Material 2

Download
- Supplementary Material 1

Submit comment

Comment moderation successfully completed

Submit your article here

Submit an Article

Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Abstract

Click here for cited by

Supplementary data

Supplementary Material 2

Supplementary Material 1