Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Mathilde Grapin; Audrey Mirand; Didier Pinquier; Aurélie Basset; Matthieu Bendavid; Maxime Bisseux; Marion Jeannoël; Bérengère Kireche; Manoelle Kossorotoff; Anne-Sophie L’Honneur; Lila Robin; Yves Ville; Sylvain Renolleau; Véronique Lemee; Pierre-Henri Jarreau; Isabelle Desguerre; Florence Lacaille; Marianne Leruez-Ville; Clémence Guillaume; Cécile Henquell; Alexandre Lapillonne; Isabelle Schuffenecker; Mélodie Aubart

doi:10.2807/1560-7917.ES.2023.28.22.2300253

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Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023
Mathilde Grapin^1,* , Audrey Mirand^2,3,* , Didier Pinquier⁴ , Aurélie Basset⁵ , Matthieu Bendavid¹ , Maxime Bisseux^2,3 , Marion Jeannoël⁶ , Bérengère Kireche⁷ , Manoelle Kossorotoff⁸ , Anne-Sophie L’Honneur⁹ , Lila Robin⁷ , Yves Ville¹⁰ , Sylvain Renolleau¹ , Véronique Lemee¹¹ , Pierre-Henri Jarreau⁵ , Isabelle Desguerre⁸ , Florence Lacaille¹² , Marianne Leruez-Ville¹³ , Clémence Guillaume¹⁴ , Cécile Henquell^2,3 , Alexandre Lapillonne¹⁵ , Isabelle Schuffenecker^6,** , Mélodie Aubart^8,16,**
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Affiliations: ¹ Paediatric Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ² Clermont-Ferrand University Hospital, 3IHP - Infection Inflammation et Interaction Hôtes Pathogènes Virology Department, French Reference Centre for enteroviruses and parechovirus, coordination laboratory, Clermont-Ferrand, France ³ Auvergne University, LMGE UMR CNRS 6023, Team Epidemiology and pathophysiology of enterovirus Infection, Clermont-Ferrand, France ⁴ Neonatal and Paediatric Intensive Care Units, Rouen University Hospital, Rouen, France ⁵ Neonatal Intensive Care Unit, Cochin-Port Royal University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ⁶ Hospices Civils de Lyon, Virology Department, French Reference Centre for enteroviruses and parechoviruses, associated laboratory, Lyon, France ⁷ Neonatal and Paediatric Intensive Care Units, Orléans Regional Hospital, Orléans, France ⁸ Paediatric Neurology Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ⁹ Virology laboratory, Cochin University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹⁰ Obstetrics and Fetal Medicine Department, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹¹ Virology Department, Rouen University Hospital, Rouen, France ¹² Pediatric Gastroenterology-Hepatology-Nutrition Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, University of Paris, Paris, France ¹³ Clinical Microbiology laboratory and Virology unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹⁴ Orléans Hospital, Microbiology laboratory, Orléans, France ¹⁵ Neonatal Intensive Care Unit, Necker-Enfants malades University Hospital, Assistance Publique Hôpitaux de Paris, Paris Cité University, Paris, France ¹⁶ Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Imagine Institute, Institut National de la Santé et de la Recherche Médicale U1163, Paris, France ^* These authors contributed equally to the work and share the first authorship. ^** These authors contributed equally to the work and share the last authorship.

Correspondence:
Mélodie AUBART
melodie.aubart aphp.fr
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Citation style for this article: Grapin Mathilde, Mirand Audrey, Pinquier Didier, Basset Aurélie, Bendavid Matthieu, Bisseux Maxime, Jeannoël Marion, Kireche Bérengère, Kossorotoff Manoelle, L’Honneur Anne-Sophie, Robin Lila, Ville Yves, Renolleau Sylvain, Lemee Véronique, Jarreau Pierre-Henri, Desguerre Isabelle, Lacaille Florence, Leruez-Ville Marianne, Guillaume Clémence, Henquell Cécile, Lapillonne Alexandre, Schuffenecker Isabelle, Aubart Mélodie. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023. Euro Surveill. 2023;28(22):pii=2300253. https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253 Received: 17 May 2023; Accepted: 01 Jun 2023

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Abstract

We report nine severe neonatal infections caused by a new variant of echovirus 11. All were male, eight were twins. At illness onset, they were 3–5 days-old and had severe sepsis and liver failure. This new variant, detected in France since April 2022, is still circulating and has caused more fatal neonatal enterovirus infections in 2022 and 2023 (8/496; 1.6%, seven associated with echovirus 11) compared with 2016 to 2021 (7/1,774; 0.4%). National and international alerts are warranted.

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Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

Citation style for this article: <a href="/search?value1=Mathilde+Grapin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grapin Mathilde</a>, <a href="/search?value1=Audrey+Mirand&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mirand Audrey</a>, <a href="/search?value1=Didier+Pinquier&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pinquier Didier</a>, <a href="/search?value1=Aur%C3%A9lie+Basset&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Basset Aurélie</a>, <a href="/search?value1=Matthieu+Bendavid&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bendavid Matthieu</a>, <a href="/search?value1=Maxime+Bisseux&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bisseux Maxime</a>, <a href="/search?value1=Marion+Jeanno%C3%ABl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jeannoël Marion</a>, <a href="/search?value1=B%C3%A9reng%C3%A8re+Kireche&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kireche Bérengère</a>, <a href="/search?value1=Manoelle+Kossorotoff&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kossorotoff Manoelle</a>, <a href="/search?value1=Anne-Sophie+L%E2%80%99Honneur&option1=author&noRedirect=true" class="nonDisambigAuthorLink">L’Honneur Anne-Sophie</a>, <a href="/search?value1=Lila+Robin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robin Lila</a>, <a href="/search?value1=Yves+Ville&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ville Yves</a>, <a href="/search?value1=Sylvain+Renolleau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Renolleau Sylvain</a>, <a href="/search?value1=V%C3%A9ronique+Lemee&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lemee Véronique</a>, <a href="/search?value1=Pierre-Henri+Jarreau&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jarreau Pierre-Henri</a>, <a href="/search?value1=Isabelle+Desguerre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Desguerre Isabelle</a>, <a href="/search?value1=Florence+Lacaille&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lacaille Florence</a>, <a href="/search?value1=Marianne+Leruez-Ville&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leruez-Ville Marianne</a>, <a href="/search?value1=Cl%C3%A9mence+Guillaume&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Guillaume Clémence</a>, <a href="/search?value1=C%C3%A9cile+Henquell&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Henquell Cécile</a>, <a href="/search?value1=Alexandre+Lapillonne&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lapillonne Alexandre</a>, <a href="/search?value1=Isabelle+Schuffenecker&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schuffenecker Isabelle</a>, <a href="/search?value1=M%C3%A9lodie+Aubart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Aubart Mélodie</a>. Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(22):pii=2300253. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.22.2300253</a> Received: 17 May 2023;   Accepted: 01 Jun 2023

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Severe and fatal neonatal infections linked to a new variant of echovirus 11, France, July 2022 to April 2023

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