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Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
- Marius Linkevicius1 , Rémy A Bonnin2 , Erik Alm1 , Olov Svartström1 , Petra Apfalter3 , Rainer Hartl3 , Henrik Hasman4 , Louise Roer4 , Kati Räisänen5 , Laurent Dortet2 , Niels Pfennigwerth6 , Jörg B Hans6 , Ákos Tóth7 , Lilla Buzgó7 , Martin Cormican8 , Niall Delappe8 , Monica Monaco9 , Maria Giufrè9 , Antoni PA Hendrickx10 , Ørjan Samuelsen11,12 , Anna K Pöntinen11,13 , Manuela Caniça14 , Vera Manageiro14 , Jesús Oteo-Iglesias15 , María Pérez-Vázquez15 , Karin Westmo16 , Barbro Mäkitalo16 , Daniel Palm1 , Dominique L Monnet1 , Anke Kohlenberg1
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View Affiliations Hide AffiliationsAffiliations: 1 European Centre for Disease Prevention and Control, Stockholm, Sweden 2 French National Reference Center for Antimicrobial Resistance, INSERM UMR 1184, Paris-Saclay University, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France 3 Austrian National Reference Centre for Antimicrobial Resistance, Ordensklinikum Linz Elisabethinen, Linz, Austria 4 Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark 5 Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland 6 National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany 7 National Public Health Centre, Budapest, Hungary 8 University of Galway, Galway, Ireland 9 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy 10 Centre for Infectious Disease Control (CIb), National Institute for Public Health and the Environment, Bilthoven, the Netherlands 11 Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, University Hospital of North Norway, Tromsø, Norway 12 Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway 13 Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway 14 National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal 15 Laboratorio de Referencia e Investigación en Resistencia a Antibióticos del Centro Nacional de Microbiología and CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain 16 Public Health Agency of Sweden, Stockholm, SwedenCorrespondence:Anke KohlenbergAnke.Kohlenberg ecdc.europa.eu
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Citation style for this article: Linkevicius Marius, Bonnin Rémy A, Alm Erik, Svartström Olov, Apfalter Petra, Hartl Rainer, Hasman Henrik, Roer Louise, Räisänen Kati, Dortet Laurent, Pfennigwerth Niels, Hans Jörg B, Tóth Ákos, Buzgó Lilla, Cormican Martin, Delappe Niall, Monaco Monica, Giufrè Maria, Hendrickx Antoni PA, Samuelsen Ørjan, Pöntinen Anna K, Caniça Manuela, Manageiro Vera, Oteo-Iglesias Jesús, Pérez-Vázquez María, Westmo Karin, Mäkitalo Barbro, Palm Daniel, Monnet Dominique L, Kohlenberg Anke. Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022. Euro Surveill. 2023;28(19):pii=2300209. https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209 Received: 16 Apr 2023; Accepted: 10 May 2023
Abstract
Whole genome sequencing data of 874 Escherichia coli isolates carrying blaNDM-5 from 13 European Union/European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an increasing frequency of detection. Nearly a third (30.6%) of these isolates were associated with infections and more than half (58.2%) were predicted to be multidrug-resistant. Further spread of E. coli carrying blaNDM-5 would leave limited treatment options for serious E. coli infections.
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2023-05-11
2024-12-26
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Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
<p class="citation">
<span>Citation style for this article:</span>
<span class="meta-value authors">
<a href="/search?value1=Marius+Linkevicius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Linkevicius Marius</a>,
<a href="/search?value1=R%C3%A9my+A+Bonnin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bonnin Rémy A</a>,
<a href="/search?value1=Erik+Alm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alm Erik</a>,
<a href="/search?value1=Olov+Svartstr%C3%B6m&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Svartström Olov</a>,
<a href="/search?value1=Petra+Apfalter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Apfalter Petra</a>,
<a href="/search?value1=Rainer+Hartl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hartl Rainer</a>,
<a href="/search?value1=Henrik+Hasman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasman Henrik</a>,
<a href="/search?value1=Louise+Roer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roer Louise</a>,
<a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>,
<a href="/search?value1=Laurent+Dortet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dortet Laurent</a>,
<a href="/search?value1=Niels+Pfennigwerth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfennigwerth Niels</a>,
<a href="/search?value1=J%C3%B6rg+B+Hans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hans Jörg B</a>,
<a href="/search?value1=%C3%81kos+T%C3%B3th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tóth Ákos</a>,
<a href="/search?value1=Lilla+Buzg%C3%B3&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buzgó Lilla</a>,
<a href="/search?value1=Martin+Cormican&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cormican Martin</a>,
<a href="/search?value1=Niall+Delappe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delappe Niall</a>,
<a href="/search?value1=Monica+Monaco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monaco Monica</a>,
<a href="/search?value1=Maria+Giufr%C3%A8&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giufrè Maria</a>,
<a href="/search?value1=Antoni+PA+Hendrickx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hendrickx Antoni PA</a>,
<a href="/search?value1=%C3%98rjan+Samuelsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Samuelsen Ørjan</a>,
<a href="/search?value1=Anna+K+P%C3%B6ntinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pöntinen Anna K</a>,
<a href="/search?value1=Manuela+Cani%C3%A7a&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caniça Manuela</a>,
<a href="/search?value1=Vera+Manageiro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Manageiro Vera</a>,
<a href="/search?value1=Jes%C3%BAs+Oteo-Iglesias&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oteo-Iglesias Jesús</a>,
<a href="/search?value1=Mar%C3%ADa+P%C3%A9rez-V%C3%A1zquez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez-Vázquez María</a>,
<a href="/search?value1=Karin+Westmo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Westmo Karin</a>,
<a href="/search?value1=Barbro+M%C3%A4kitalo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mäkitalo Barbro</a>,
<a href="/search?value1=Daniel+Palm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palm Daniel</a>,
<a href="/search?value1=Dominique+L+Monnet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monnet Dominique L</a>,
<a href="/search?value1=Anke+Kohlenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kohlenberg Anke</a></span>.
Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022.
<a href="/content/ecdc">Euro Surveill.</a> 2023;28(19):pii=2300209.
<a href="https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209</a>
<span class="ES_Article_citation">
<span class="generated">Received</span>: 16 Apr 2023;
<span class="generated">Accepted</span>: 10 May 2023
</span>
</p>
/content/10.2807/1560-7917.ES.2023.28.19.2300209
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