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Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
- Marius Linkevicius1 , Rémy A Bonnin2 , Erik Alm1 , Olov Svartström1 , Petra Apfalter3 , Rainer Hartl3 , Henrik Hasman4 , Louise Roer4 , Kati Räisänen5 , Laurent Dortet2 , Niels Pfennigwerth6 , Jörg B Hans6 , Ákos Tóth7 , Lilla Buzgó7 , Martin Cormican8 , Niall Delappe8 , Monica Monaco9 , Maria Giufrè9 , Antoni PA Hendrickx10 , Ørjan Samuelsen11,12 , Anna K Pöntinen11,13 , Manuela Caniça14 , Vera Manageiro14 , Jesús Oteo-Iglesias15 , María Pérez-Vázquez15 , Karin Westmo16 , Barbro Mäkitalo16 , Daniel Palm1 , Dominique L Monnet1 , Anke Kohlenberg1
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View Affiliations Hide AffiliationsAffiliations: 1 European Centre for Disease Prevention and Control, Stockholm, Sweden 2 French National Reference Center for Antimicrobial Resistance, INSERM UMR 1184, Paris-Saclay University, Bicêtre Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France 3 Austrian National Reference Centre for Antimicrobial Resistance, Ordensklinikum Linz Elisabethinen, Linz, Austria 4 Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark 5 Department of Health Security, Finnish Institute for Health and Welfare, Helsinki, Finland 6 National Reference Centre for multidrug-resistant Gram-negative bacteria, Ruhr University Bochum, Bochum, Germany 7 National Public Health Centre, Budapest, Hungary 8 University of Galway, Galway, Ireland 9 Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy 10 Centre for Infectious Disease Control (CIb), National Institute for Public Health and the Environment, Bilthoven, the Netherlands 11 Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, University Hospital of North Norway, Tromsø, Norway 12 Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway 13 Department of Biostatistics, Faculty of Medicine, University of Oslo, Oslo, Norway 14 National Reference Laboratory of Antibiotic Resistances and Healthcare Associated Infections, Department of Infectious Diseases, National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal 15 Laboratorio de Referencia e Investigación en Resistencia a Antibióticos del Centro Nacional de Microbiología and CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain 16 Public Health Agency of Sweden, Stockholm, SwedenCorrespondence:Anke KohlenbergAnke.Kohlenberg ecdc.europa.eu
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Citation style for this article: Linkevicius Marius, Bonnin Rémy A, Alm Erik, Svartström Olov, Apfalter Petra, Hartl Rainer, Hasman Henrik, Roer Louise, Räisänen Kati, Dortet Laurent, Pfennigwerth Niels, Hans Jörg B, Tóth Ákos, Buzgó Lilla, Cormican Martin, Delappe Niall, Monaco Monica, Giufrè Maria, Hendrickx Antoni PA, Samuelsen Ørjan, Pöntinen Anna K, Caniça Manuela, Manageiro Vera, Oteo-Iglesias Jesús, Pérez-Vázquez María, Westmo Karin, Mäkitalo Barbro, Palm Daniel, Monnet Dominique L, Kohlenberg Anke. Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022. Euro Surveill. 2023;28(19):pii=2300209. https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209 Received: 16 Apr 2023; Accepted: 10 May 2023
Abstract
Whole genome sequencing data of 874 Escherichia coli isolates carrying blaNDM-5 from 13 European Union/European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an increasing frequency of detection. Nearly a third (30.6%) of these isolates were associated with infections and more than half (58.2%) were predicted to be multidrug-resistant. Further spread of E. coli carrying blaNDM-5 would leave limited treatment options for serious E. coli infections.
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2023-05-11
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.19.2300209
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References
-
European Centre for Disease Prevention and Control (ECDC). ECDC study protocol for genomic-based surveillance of carbapenem-resistant and/or colistin-resistant Enterobacteriaceae at the EU level. Version 2.0. Stockholm: ECDC; 2018. Available from: https://ecdc.europa.eu/en/publications-data/ecdc-study-protocol-genomic-based-surveillance-carbapenem-resistant-andor
-
Manges AR, Geum HM, Guo A, Edens TJ, Fibke CD, Pitout JDD. Global extraintestinal pathogenic Escherichia coli (ExPEC) lineages. Clin Microbiol Rev. 2019;32(3):e00135-18. https://doi.org/10.1128/CMR.00135-18 PMID: 31189557
-
Zhou Z, Alikhan NF, Mohamed K, Fan Y, Agama Study Group, Achtman M. The EnteroBase user’s guide, with case studies on Salmonella transmissions, Yersinia pestis phylogeny, and Escherichia core genomic diversity. Genome Res. 2020;30(1):138-52. https://doi.org/10.1101/gr.251678.119 PMID: 31809257
-
Larsen MV, Cosentino S, Rasmussen S, Friis C, Hasman H, Marvig RL, et al. Multilocus sequence typing of total-genome-sequenced bacteria. J Clin Microbiol. 2012;50(4):1355-61. https://doi.org/10.1128/JCM.06094-11 PMID: 22238442
-
Peirano G, Chen L, Nobrega D, Finn TJ, Kreiswirth BN, DeVinney R, et al. Genomic epidemiology of global carbapenemase-producing Escherichia coli, 2015-2017. Emerg Infect Dis. 2022;28(5):924-31. https://doi.org/10.3201/eid2805.212535 PMID: 35451367
-
Zankari E, Allesøe R, Joensen KG, Cavaco LM, Lund O, Aarestrup FM. PointFinder: a novel web tool for WGS-based detection of antimicrobial resistance associated with chromosomal point mutations in bacterial pathogens. J Antimicrob Chemother. 2017;72(10):2764-8. https://doi.org/10.1093/jac/dkx217 PMID: 29091202
-
Schürch AC, Arredondo-Alonso S, Willems RJL, Goering RV. Whole genome sequencing options for bacterial strain typing and epidemiologic analysis based on single nucleotide polymorphism versus gene-by-gene-based approaches. Clin Microbiol Infect. 2018;24(4):350-4. https://doi.org/10.1016/j.cmi.2017.12.016 PMID: 29309930
-
Garcia-Fernandez A, Villa L, Bibbolino G, Bressan A, Trancassini M, Pietropaolo V, et al. Novel insights and features of the NDM-5-producing Escherichia coli sequence type 167 high-risk clone. MSphere. 2020;5(2):e00269-20. https://doi.org/10.1128/mSphere.00269-20 PMID: 32350092
-
Barrado L, Pérez-Vázquez M, Del Pozo JL, Martín-Salas C, Leiva J, Mazón A, et al. Clonal transmission of NDM-5-producing Escherichia coli belonging to high-risk sequence type ST405. Int J Antimicrob Agents. 2018;52(1):123-4. https://doi.org/10.1016/j.ijantimicag.2018.05.018 PMID: 29864499
-
Bibbolino G, Di Lella FM, Oliva A, Lichtner M, Del Borgo C, Raponi G, et al. Molecular epidemiology of NDM-5-producing Escherichia coli high-risk clones identified in two Italian hospitals in 2017-2019. Diagn Microbiol Infect Dis. 2021;100(4):115399. https://doi.org/10.1016/j.diagmicrobio.2021.115399 PMID: 34030105
-
Roer L, Overballe-Petersen S, Hansen F, Schønning K, Wang M, Røder BL, et al. Escherichia coli sequence type 410 is causing new international high-risk clones. MSphere. 2018;3(4):e00337-18. https://doi.org/10.1128/mSphere.00337-18 PMID: 30021879
-
Turton JF, Pike R, Perry C, Jenkins C, Turton JA, Meunier D, et al. Wide distribution of Escherichia coli carrying IncF plasmids containing blaNDM-5 and rmtB resistance genes from hospitalized patients in England. J Med Microbiol. 2022;71(8). https://doi.org/10.1099/jmm.0.001569 PMID: 35925786
-
Hans JB, Pfennigwerth N, Neumann B, Pfeifer Y, Fischer MA, Eisfeld J, et al. Molecular surveillance reveals the emergence and dissemination of NDM-5-producing Escherichia coli high-risk clones in Germany, 2013 to 2019. Euro Surveill. 2023;28(10):2200509. https://doi.org/10.2807/1560-7917.ES.2023.28.10.2200509 PMID: 36892470
-
Chakraborty T, Sadek M, Yao Y, Imirzalioglu C, Stephan R, Poirel L, et al. Cross-border emergence of Escherichia coli producing the carbapenemase NDM-5 in Switzerland and Germany. J Clin Microbiol. 2021;59(3):e02238-20. https://doi.org/10.1128/JCM.02238-20 PMID: 33361340
-
Cummins EA, Snaith AE, McNally A, Hall RJ. The role of potentiating mutations in the evolution of pandemic Escherichia coli clones. Eur J Clin Microbiol Infect Dis. 2021. https://doi.org/10.1007/s10096-021-04359-3 PMID: 34787747
-
Schaufler K, Semmler T, Wieler LH, Trott DJ, Pitout J, Peirano G, et al. Genomic and functional analysis of emerging virulent and multidrug-resistant Escherichia coli lineage sequence type 648. Antimicrob Agents Chemother. 2019;63(6):e00243-19. https://doi.org/10.1128/AAC.00243-19 PMID: 30885899
-
Cox G, Ejim L, Stogios PJ, Koteva K, Bordeleau E, Evdokimova E, et al. Plazomicin retains antibiotic activity against most aminoglycoside modifying enzymes. ACS Infect Dis. 2018;4(6):980-7. https://doi.org/10.1021/acsinfecdis.8b00001 PMID: 29634241
-
Bonnin RA, Emeraud C, Jousset AB, Naas T, Dortet L. Comparison of disk diffusion, MIC test strip and broth microdilution methods for cefiderocol susceptibility testing on carbapenem-resistant Enterobacterales. Clin Microbiol Infect. 2022;28(8):1156.e1-5. https://doi.org/10.1016/j.cmi.2022.04.013 PMID: 35533970
-
Simner PJ, Mostafa HH, Bergman Y, Ante M, Tekle T, Adebayo A, et al. Progressive development of cefiderocol resistance in Escherichia coli during therapy is associated with an increase in blaNDM-5 copy number and gene expression. Clin Infect Dis. 2022;75(1):47-54. https://doi.org/10.1093/cid/ciab888 PMID: 34618008
-
European Centre for Disease Prevention and Control (ECDC). Antimicrobial resistance in the EU/EEA (EARS-Net) - Annual epidemiological report for 2021. Stockholm: ECDC; 2022. Available from: https://www.ecdc.europa.eu/en/publications-data/surveillance-antimicrobial-resistance-europe-2021
Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
<p class="citation">
<span>Citation style for this article:</span>
<span class="meta-value authors">
<a href="/search?value1=Marius+Linkevicius&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Linkevicius Marius</a>,
<a href="/search?value1=R%C3%A9my+A+Bonnin&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bonnin Rémy A</a>,
<a href="/search?value1=Erik+Alm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Alm Erik</a>,
<a href="/search?value1=Olov+Svartstr%C3%B6m&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Svartström Olov</a>,
<a href="/search?value1=Petra+Apfalter&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Apfalter Petra</a>,
<a href="/search?value1=Rainer+Hartl&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hartl Rainer</a>,
<a href="/search?value1=Henrik+Hasman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasman Henrik</a>,
<a href="/search?value1=Louise+Roer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Roer Louise</a>,
<a href="/search?value1=Kati+R%C3%A4is%C3%A4nen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Räisänen Kati</a>,
<a href="/search?value1=Laurent+Dortet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Dortet Laurent</a>,
<a href="/search?value1=Niels+Pfennigwerth&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pfennigwerth Niels</a>,
<a href="/search?value1=J%C3%B6rg+B+Hans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hans Jörg B</a>,
<a href="/search?value1=%C3%81kos+T%C3%B3th&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tóth Ákos</a>,
<a href="/search?value1=Lilla+Buzg%C3%B3&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buzgó Lilla</a>,
<a href="/search?value1=Martin+Cormican&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cormican Martin</a>,
<a href="/search?value1=Niall+Delappe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Delappe Niall</a>,
<a href="/search?value1=Monica+Monaco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monaco Monica</a>,
<a href="/search?value1=Maria+Giufr%C3%A8&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giufrè Maria</a>,
<a href="/search?value1=Antoni+PA+Hendrickx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hendrickx Antoni PA</a>,
<a href="/search?value1=%C3%98rjan+Samuelsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Samuelsen Ørjan</a>,
<a href="/search?value1=Anna+K+P%C3%B6ntinen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pöntinen Anna K</a>,
<a href="/search?value1=Manuela+Cani%C3%A7a&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Caniça Manuela</a>,
<a href="/search?value1=Vera+Manageiro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Manageiro Vera</a>,
<a href="/search?value1=Jes%C3%BAs+Oteo-Iglesias&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Oteo-Iglesias Jesús</a>,
<a href="/search?value1=Mar%C3%ADa+P%C3%A9rez-V%C3%A1zquez&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pérez-Vázquez María</a>,
<a href="/search?value1=Karin+Westmo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Westmo Karin</a>,
<a href="/search?value1=Barbro+M%C3%A4kitalo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mäkitalo Barbro</a>,
<a href="/search?value1=Daniel+Palm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palm Daniel</a>,
<a href="/search?value1=Dominique+L+Monnet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Monnet Dominique L</a>,
<a href="/search?value1=Anke+Kohlenberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kohlenberg Anke</a></span>.
Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022.
<a href="/content/ecdc">Euro Surveill.</a> 2023;28(19):pii=2300209.
<a href="https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.19.2300209</a>
<span class="ES_Article_citation">
<span class="generated">Received</span>: 16 Apr 2023;
<span class="generated">Accepted</span>: 10 May 2023
</span>
</p>
/content/10.2807/1560-7917.ES.2023.28.19.2300209
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