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Abstract

A hypervirulent SL218 (ST23-KL57), phylogenetically distinct from the classical hypervirulent SL23 (ST23-KL1) lineage, was transmitted between hospitalised patients in Denmark in 2021. The isolate carried a hybrid resistance and virulence plasmid containing and a plasmid containing (pOXA-48); the latter plasmid was horizontally transferred within-patient to . The convergence of drug resistance and virulence factors in single plasmids and in different lineages of is concerning and requires surveillance.

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/content/10.2807/1560-7917.ES.2023.28.17.2300196
2023-04-27
2024-12-24
/content/10.2807/1560-7917.ES.2023.28.17.2300196
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Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Karen+Leth+Nielsen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nielsen Karen Leth</a>, <a href="/search?value1=Marc+S%C3%B8rensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sørensen Marc</a>, <a href="/search?value1=Frederik+Bo%C3%ABtius+Hertz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hertz Frederik Boëtius</a>, <a href="/search?value1=Maria+Anna+Misiakou&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Misiakou Maria Anna</a>, <a href="/search?value1=Henrik+Hasman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hasman Henrik</a>, <a href="/search?value1=Susanne+H%C3%A4ussler&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Häussler Susanne</a>, <a href="/search?value1=Marie+Helleberg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Helleberg Marie</a>, <a href="/search?value1=Kristian+Sch%C3%B8nning&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schønning Kristian</a></span>. Within-patient horizontal transfer of pOXA-48 from a hypervirulent Klebsiella pneumoniae SL218 to Serratia marcescens following spread of the K. pneumoniae isolate among hospitalised patients, Denmark, 2021 . <a href="/content/ecdc">Euro Surveill.</a> 2023;28(17):pii=2300196. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.17.2300196</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 01 Apr 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 27 Apr 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.17.2300196
/content/10.2807/1560-7917.ES.2023.28.17.2300196
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