1887
  1. Home
  2. Eurosurveillance
  3. Volume 28, Issue 14, 06/Apr/2023
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

A difficult-to-control outbreak of is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of S639F and F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2023.28.14.2300161
2023-04-06
2024-12-18
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2023.28.14.2300161
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/28/14/eurosurv-28-14-1.html?itemId=/content/10.2807/1560-7917.ES.2023.28.14.2300161&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO). WHO fungal priority pathogens list to guide research, development and public health action. Geneva: WHO; 2022. ISBN 978-92-4-006024-1. Available from: https://www.who.int/publications/i/item/9789240060241
  2. Kohlenberg A, Monnet DL, Plachouras D, Candida auris survey collaborative group. Increasing number of cases and outbreaks caused by Candida auris in the EU/EEA, 2020 to 2021. Euro Surveill. 2022;27(46):1-6.  https://doi.org/10.2807/1560-7917.ES.2022.27.46.2200846  PMID: 36398575 
  3. Geremia N, Brugnaro P, Solinas M, Scarparo C, Panese S. Candida auris as an Emergent Public Health Problem: A Current Update on European Outbreaks and Cases. Healthcare (Basel). 2023;11(3):425.  https://doi.org/10.3390/healthcare11030425  PMID: 36767000 
  4. Crea F, Codda G, Orsi A, Battaglini A, Giacobbe DR, Delfino E, et al. Isolation of Candida auris from invasive and non-invasive samples of a patient suffering from vascular disease, Italy, July 2019. Euro Surveill. 2019;24(37):1900549.  https://doi.org/10.2807/1560-7917.ES.2019.24.37.1900549  PMID: 31530343 
  5. European Centre for Disease Prevention and Control (ECDC). Candida auris outbreak in healthcare facilities in northern Italy, 2019-2021. Stockholm: ECDC; 2022. Available from: https://www.ecdc.europa.eu/en/publications-data/rapid-risk-assessment-candida-auris-outbreak-healthcare-facilities-northern-italy
  6. Di Pilato V, Codda G, Ball L, Giacobbe DR, Willison E, Mikulska M, et al. Molecular epidemiological investigation of a nosocomial cluster of c. Auris: Evidence of recent emergence in italy and ease of transmission during the covid‐19 pandemic. J Fungi (Basel). 2021;7(2):140.  https://doi.org/10.3390/jof7020140  PMID: 33672021 
  7. Muñoz JF, Welsh RM, Shea T, Batra D, Gade L, Howard D, et al. Clade-specific chromosomal rearrangements and loss of subtelomeric adhesins in Candida auris. Genetics. 2021;218(1):iyab029.  https://doi.org/10.1093/genetics/iyab029  PMID: 33769478 
  8. Welsh RM, Misas E, Forsberg K, Lyman M, Chow NA. Candida auris whole-genome sequence benchmark dataset for phylogenomic pipelines. J Fungi (Basel). 2021;7(3):214.  https://doi.org/10.3390/jof7030214  PMID: 33809682 
  9. Pchelin IM, Azarov DV, Churina MA, Ryabinin IA, Vibornova IV, Apalko SV, et al. Whole genome sequence of first Candida auris strain, isolated in Russia. Med Mycol. 2020;58(3):414-6.  https://doi.org/10.1093/mmy/myz078  PMID: 31290551 
  10. Centers for Disease Control and Prevention (CDC). Antifungal susceptibility testing and interpretation. Atlanta: CDC; 2020. Available from: https://www.cdc.gov/fungal/candida-auris/c-auris-antifungal.html
  11. Briano F, Magnasco L, Sepulcri C, Dettori S, Dentone C, Mikulska M, et al. Candida auris candidemia in critically ill, colonized patients: cumulative incidence and risk factors. Infect Dis Ther. 2022;11(3):1149-60.  https://doi.org/10.1007/s40121-022-00625-9  PMID: 35404010 
  12. Chow NA, Gade L, Tsay SV, Forsberg K, Greenko JA, Southwick KL, et al. Multiple introductions and subsequent transmission of multidrug-resistant Candida auris in the USA: a molecular epidemiological survey. Lancet Infect Dis. 2018;18(12):1377-84.  https://doi.org/10.1016/S1473-3099(18)30597-8  PMID: 30293877 
  13. Biswas C, Wang Q, van Hal SJ, Eyre DW, Hudson B, Halliday CL, et al. Genetic heterogeneity of australian candida auris isolates: Insights from a nonoutbreak setting using whole-genome sequencing. Open Forum Infect Dis. 2020;7(5):ofaa158.  https://doi.org/10.1093/ofid/ofaa158  PMID: 32500091 
  14. Sticchi C, Raso R, Ferrara L, Vecchi E, Ferrero L, Filippi D, et al. Increasing number of cases due to Candida auris in North Italy, July 2019-December 2022. J Clin Med. 2023;12(5):1912.  https://doi.org/10.3390/jcm12051912  PMID: 36902700 
  15. Lyman M, Forsberg K, Sexton DJ, Chow NA, Lockhart SR, Jackson BR, et al. Worsening spread of Candida auris in the United States, 2019 to 2021. Ann Intern Med. 2023;M22-3469.  https://doi.org/10.7326/M22-3469  PMID: 36940442 
  16. Chaabane F, Graf A, Jequier L, Coste AT. Review on antifungal resistance mechanisms in the emerging pathogen Candida auris. Front Microbiol. 2019;10:2788.  https://doi.org/10.3389/fmicb.2019.02788  PMID: 31849919 
  17. Rybak JM, Cuomo CA, Rogers PD. The molecular and genetic basis of antifungal resistance in the emerging fungal pathogen Candida auris. Curr Opin Microbiol. 2022;70:102208.  https://doi.org/10.1016/j.mib.2022.102208  PMID: 36242897 
  18. Sharma D, Paul RA, Rudramurthy SM, Kashyap N, Bhattacharya S, Soman R, et al. Impact of FKS1 genotype on echinocandin in vitro susceptibility in Candida auris and in vivo response in a murine model of infection. Antimicrob Agents Chemother. 2022;66(1):e0165221.  https://doi.org/10.1128/AAC.01652-21  PMID: 34780273 
In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Giulia+Codda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Codda Giulia</a>, <a href="/search?value1=Edward+Willison&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Willison Edward</a>, <a href="/search?value1=Laura+Magnasco&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Magnasco Laura</a>, <a href="/search?value1=Paola+Morici&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morici Paola</a>, <a href="/search?value1=Daniele+Roberto+Giacobbe&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giacobbe Daniele Roberto</a>, <a href="/search?value1=Antonella+Mencacci&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mencacci Antonella</a>, <a href="/search?value1=Daniele+Marini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marini Daniele</a>, <a href="/search?value1=Malgorzata+Mikulska&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mikulska Malgorzata</a>, <a href="/search?value1=Matteo+Bassetti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bassetti Matteo</a>, <a href="/search?value1=Anna+Marchese&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Marchese Anna</a>, <a href="/search?value1=Vincenzo+Di+Pilato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Di Pilato Vincenzo</a></span>. In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022. <a href="/content/ecdc">Euro Surveill.</a> 2023;28(14):pii=2300161. <a href="https://doi.org/10.2807/1560-7917.ES.2023.28.14.2300161" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2023.28.14.2300161</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 09 Mar 2023;&nbsp;&nbsp; <span class="generated">Accepted</span>: 05 Apr 2023 </span> </p>
/content/10.2807/1560-7917.ES.2023.28.14.2300161
/content/10.2807/1560-7917.ES.2023.28.14.2300161
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error