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Abstract

Between December 2021 and June 2022, 10 cases of ceftriaxone-resistant (ST8123; n = 8) were detected in the United Kingdom, compared with nine cases during the previous 6 years. Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. Although all cases were successfully treated, not all partners of cases could be traced, and there is a risk of further transmission of ceftriaxone-resistant gonococcal infection within the UK.

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/content/10.2807/1560-7917.ES.2022.27.46.2200803
2022-11-17
2024-12-21
/content/10.2807/1560-7917.ES.2022.27.46.2200803
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References

  1. Chen SC, Yuan LF, Zhu XY, van der Veen S, Yin YP. Sustained transmission of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone in China. J Antimicrob Chemother. 2020;75(9):2499-502.  https://doi.org/10.1093/jac/dkaa196  PMID: 32473014 
  2. Lee K, Nakayama SI, Osawa K, Yoshida H, Arakawa S, Furubayashi KI, et al. Clonal expansion and spread of the ceftriaxone-resistant Neisseria gonorrhoeae strain FC428, identified in Japan in 2015, and closely related isolates. J Antimicrob Chemother. 2019;74(7):1812-9.  https://doi.org/10.1093/jac/dkz129  PMID: 31002306 
  3. Trinh TM, Nguyen TT, Le TV, Nguyen TT, Ninh DT, Duong BH, et al. Neisseria gonorrhoeae FC428 Subclone, Vietnam, 2019-2020. Emerg Infect Dis. 2022;28(2):432-5.  https://doi.org/10.3201/eid2802.211788  PMID: 35076010 
  4. Nakayama S, Shimuta K, Furubayashi K, Kawahata T, Unemo M, Ohnishi M. New ceftriaxone- and multidrug-resistant Neisseria gonorrhoeae strain with a novel mosaic penA gene isolated in Japan. Antimicrob Agents Chemother. 2016;60(7):4339-41.  https://doi.org/10.1128/AAC.00504-16  PMID: 27067334 
  5. Eyre DW, Sanderson ND, Lord E, Regisford-Reimmer N, Chau K, Barker L, et al. Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018. Euro Surveill. 2018;23(27):1800323.  https://doi.org/10.2807/1560-7917.ES.2018.23.27.1800323  PMID: 29991383 
  6. Pleininger S, Indra A, Golparian D, Heger F, Schindler S, Jacobsson S, et al. Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022. Euro Surveill. 2022;27(24):2200455.  https://doi.org/10.2807/1560-7917.ES.2022.27.24.2200455  PMID: 35713023 
  7. The European Committee on Antimicrobial Susceptibility Testing (EUCAST). Breakpoint tables for interpretation of MICs and zone diameters. Version 12.0. Växjö: EUCAST; 2022. http://www.eucast.org/clinical_breakpoints
  8. Sánchez-Busó L, Yeats CA, Taylor B, Goater RJ, Underwood A, Abudahab K, et al. A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch. Genome Med. 2021;13(1):61.  https://doi.org/10.1186/s13073-021-00858-2  PMID: 33875000 
  9. Harris SR, Cole MJ, Spiteri G, Sánchez-Busó L, Golparian D, Jacobsson S, et al. Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey. Lancet Infect Dis. 2018;18(7):758-68.  https://doi.org/10.1016/S1473-3099(18)30225-1  PMID: 29776807 
  10. Sánchez-Busó L, Cole MJ, Spiteri G, Day M, Jacobsson S, Golparian D, et al. Europe-wide expansion and eradication of multidrug-resistant Neisseria gonorrhoeae lineages: a genomic surveillance study. Lancet Microbe. 2022;3(6):e452-63.  https://doi.org/10.1016/S2666-5247(22)00044-1  PMID: 35659907 
  11. Li Y, Li Y, Xiu L, Zeng Y, Zhang C, Sun L, et al. Typing of Neisseria Gonorrhoeae isolates in Shenzhen, China from 2014-2018 reveals the shift of genotypes associated with antimicrobial resistance. Antimicrob Agents Chemother. 2021;65(5):e02311-20.  https://doi.org/10.1128/AAC.02311-20  PMID: 33593843 
  12. Ng LK, Martin I, Liu G, Bryden L. Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2002;46(9):3020-5.  https://doi.org/10.1128/AAC.46.9.3020-3025.2002  PMID: 12183262 
  13. Lee H, Suh YH, Lee S, Kim YK, Han MS, Bae HG, et al. Emergence and spread of cephalosporin-resistant Neisseria gonorrhoeae with mosaic penA alleles, South Korea, 2012-2017. Emerg Infect Dis. 2019;25(3):416-24.  https://doi.org/10.3201/eid2503.181503  PMID: 30789143 
  14. Gianecini RA, Golparian D, Zittermann S, Litvik A, Gonzalez S, Oviedo C, et al. Genome-based epidemiology and antimicrobial resistance determinants of Neisseria gonorrhoeae isolates with decreased susceptibility and resistance to extended-spectrum cephalosporins in Argentina in 2011-16. J Antimicrob Chemother. 2019;74(6):1551-9.  https://doi.org/10.1093/jac/dkz054  PMID: 30820563 
  15. Shimuta K, Unemo M, Nakayama S, Morita-Ishihara T, Dorin M, Kawahata T, et al. Antimicrobial resistance and molecular typing of Neisseria gonorrhoeae isolates in Kyoto and Osaka, Japan, 2010 to 2012: intensified surveillance after identification of the first strain (H041) with high-level ceftriaxone resistance. Antimicrob Agents Chemother. 2013;57(11):5225-32.  https://doi.org/10.1128/AAC.01295-13  PMID: 23939890 
  16. Unemo M, Nicholas RA. Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea. Future Microbiol. 2012;7(12):1401-22.  https://doi.org/10.2217/fmb.12.117  PMID: 23231489 
  17. Cámara J, Serra J, Ayats J, Bastida T, Carnicer-Pont D, Andreu A, et al. Molecular characterization of two high-level ceftriaxone-resistant Neisseria gonorrhoeae isolates detected in Catalonia, Spain. J Antimicrob Chemother. 2012;67(8):1858-60.  https://doi.org/10.1093/jac/dks162  PMID: 22566592 
  18. Unemo M, Golparian D, Nicholas R, Ohnishi M, Gallay A, Sednaoui P. High-level cefixime- and ceftriaxone-resistant Neisseria gonorrhoeae in France: novel penA mosaic allele in a successful international clone causes treatment failure. Antimicrob Agents Chemother. 2012;56(3):1273-80.  https://doi.org/10.1128/AAC.05760-11  PMID: 22155830 
  19. Chow EPF, Cornelisse VJ, Williamson DA, Priest D, Hocking JS, Bradshaw CS, et al. Kissing may be an important and neglected risk factor for oropharyngeal gonorrhoea: a cross-sectional study in men who have sex with men. Sex Transm Infect. 2019;95(7):516-21.  https://doi.org/10.1136/sextrans-2018-053896  PMID: 31073095 
  20. Eyre DW, Town K, Street T, Barker L, Sanderson N, Cole MJ, et al. Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018. Euro Surveill. 2019;24(10):1900147.  https://doi.org/10.2807/1560-7917.ES.2019.24.10.1900147  PMID: 30862336 
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