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Abstract

Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.

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/content/10.2807/1560-7917.ES.2022.27.4.2101196
2022-01-27
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.4.2101196
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Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Dirk+Eggink&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Eggink Dirk</a>, <a href="/search?value1=Stijn+P+Andeweg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Andeweg Stijn P</a>, <a href="/search?value1=Harry+Vennema&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vennema Harry</a>, <a href="/search?value1=Noortje+van+Maarseveen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Maarseveen Noortje</a>, <a href="/search?value1=Klaas+Vermaas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vermaas Klaas</a>, <a href="/search?value1=Boris+Vlaemynck&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vlaemynck Boris</a>, <a href="/search?value1=Raf+Schepers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schepers Raf</a>, <a href="/search?value1=Arianne+B+van+Gageldonk-Lafeber&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van Gageldonk-Lafeber Arianne B</a>, <a href="/search?value1=Susan+van+den+Hof&option1=author&noRedirect=true" class="nonDisambigAuthorLink">van den Hof Susan</a>, <a href="/search?value1=Chantal+BEM+Reusken&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Reusken Chantal BEM</a>, <a href="/search?value1=Mirjam+J+Knol&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Knol Mirjam J</a></span>. Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(4):pii=2101196. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.4.2101196" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.4.2101196</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 29 Dec 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 27 Jan 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.4.2101196
/content/10.2807/1560-7917.ES.2022.27.4.2101196
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