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Abstract

In Italy, serogroup C meningococci of the clonal complex cc11 (MenC/cc11) have caused several outbreaks of invasive meningococcal disease (IMD) during the past 20 years. Between December 2019 and January 2020, an outbreak of six cases of IMD infected with MenC/cc11 was identified in a limited area in the northern part of Italy. All cases presented a severe clinical picture, and two of them were fatal. This report is focused on the microbiological and molecular analysis of meningococcal isolates with the aim to reconstruct the chain of transmission. It further presents the vaccination strategy adopted to control the outbreak. The phylogenetic evaluation demonstrated the close genetic proximity between the strain involved in this outbreak and a strain responsible for a larger epidemic that had occurred in 2015 and 2016 in the Tuscany Region. The rapid identification and characterisation of IMD cases and an extensive vaccination campaign contributed to the successful control of this outbreak caused by a hyperinvasive meningococcal strain.

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/content/10.2807/1560-7917.ES.2022.27.24.2100919
2022-06-16
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.24.2100919
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Reactive vaccination as control strategy for an outbreak of invasive meningococcal disease caused by Neisseria meningitidis C:P1.5-1,10-8:F3-6:ST-11(cc11), Bergamo province, Italy, December 2019 to January 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Cecilia+Fazio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fazio Cecilia</a>, <a href="/search?value1=Laura+Daprai&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Daprai Laura</a>, <a href="/search?value1=Arianna+Neri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Neri Arianna</a>, <a href="/search?value1=Marcello+Tirani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tirani Marcello</a>, <a href="/search?value1=Paola+Vacca&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vacca Paola</a>, <a href="/search?value1=Milena+Arghittu&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Arghittu Milena</a>, <a href="/search?value1=Luigina+Ambrosio&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ambrosio Luigina</a>, <a href="/search?value1=Danilo+Cereda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cereda Danilo</a>, <a href="/search?value1=Maria+Gramegna&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gramegna Maria</a>, <a href="/search?value1=Annapina+Palmieri&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palmieri Annapina</a>, <a href="/search?value1=Anna+Carannante&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Carannante Anna</a>, <a href="/search?value1=Maria+Rosa+Bertoli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bertoli Maria Rosa</a>, <a href="/search?value1=Lucia+Crottogini&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Crottogini Lucia</a>, <a href="/search?value1=Giorgio+Gennati&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gennati Giorgio</a>, <a href="/search?value1=Eugenia+Quinz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Quinz Eugenia</a>, <a href="/search?value1=Livia+Trezzi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Trezzi Livia</a>, <a href="/search?value1=Andrea+Ciammaruconi&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ciammaruconi Andrea</a>, <a href="/search?value1=Silvia+Fillo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fillo Silvia</a>, <a href="/search?value1=Antonella+Fortunato&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fortunato Antonella</a>, <a href="/search?value1=Giovanni+Rezza&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rezza Giovanni</a>, <a href="/search?value1=Florigio+Lista&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lista Florigio</a>, <a href="/search?value1=Paola+Stefanelli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stefanelli Paola</a></span>. Reactive vaccination as control strategy for an outbreak of invasive meningococcal disease caused by Neisseria meningitidis C:P1.5-1,10-8:F3-6:ST-11(cc11), Bergamo province, Italy, December 2019 to January 2020. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(24):pii=2100919. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.24.2100919" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.24.2100919</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 10 Sept 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 03 Mar 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.24.2100919
/content/10.2807/1560-7917.ES.2022.27.24.2100919
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