1887
  1. Home
  2. Eurosurveillance
  3. Volume 27, Issue 19, 12/May/2022
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

To detect potential concern about severe acute hepatitis in children, we conducted a survey among 50 ERN RARE-LIVER centres. By 26 April 2022, 34 centres, including 25 transplant centres, reported an estimated median of 3–5, 0–2 and 3–5 cases in 2021, 2020 and 2019 and a mean of 2 (range: 0–8) cases between January and April 2022 (mean in 10 large liver transplant centres: 3). Twelve centres reported suspicion of an increase, but no rise.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2022.27.19.2200369
2022-05-12
2024-12-21
/content/10.2807/1560-7917.ES.2022.27.19.2200369
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/27/19/eurosurv-27-19-3.html?itemId=/content/10.2807/1560-7917.ES.2022.27.19.2200369&mimeType=html&fmt=ahah

References

  1. World Health Organization (WHO). Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland. Geneva: WHO; 15 Apr 2022. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/acute-hepatitis-of-unknown-aetiology---the-united-kingdom-of-great-britain-and-northern-ireland
  2. European Centre for Disease Prevention and Control (ECDC). Increase in severe acute hepatitis cases of unknown aetiology in children. Stockholm: ECDC; 28 Apr 2022. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/RRA-20220420-218.pdf
  3. World Health Organization (WHO). Multi-Country – Acute, severe hepatitis of unknown origin in children. Geneva: WHO; 23 Apr 2022. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2022-DON376
  4. Christie B. Scientists search for cause of hepatitis cases in children. BMJ. 2022;377:o982.  https://doi.org/10.1136/bmj.o982  PMID: 35422430 
  5. United Kingdom Health Security Agency (UKHSA). Increase in acute hepatitis cases of unknown aetiology in children. London: UKHSA; 8 Apr 2022. Available from: https://www.gov.uk/government/publications/hepatitis-increase-in-acute-cases-of-unknown-aetiology-in-children/increase-in-acute-hepatitis-cases-of-unknown-aetiology-in-children
  6. Squire s RH Jr, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148(5):652-8. . PMID: 16737880
  7. European Reference Network (ERN). Hepatological Diseases (ERN RARE-LIVER). What is ERN RARE-LIVER? [Accessed: 10 May 2022]. Available from: https://rare-liver.eu/about/what-is-ern-rare-liver
  8. Squires RH Jr, Shneider BL, Bucuvalas J, Alonso E, Sokol RJ, Narkewicz MR, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148(5):652-8.  https://doi.org/10.1016/j.jpeds.2005.12.051  PMID: 16737880 
  9. Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, et al. , STROBE Initiative. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. PLoS Med. 2007;4(10):e297.  https://doi.org/10.1371/journal.pmed.0040297  PMID: 17941715 
  10. Mücke MM, Zeuzem S. The recent outbreak of acute severe hepatitis in children of unknown origin – what is known so far. J Hepatol. 2022;S0168-8278(22)00271-9.  https://doi.org/10.1016/j.jhep.2022.05.001 
  11. Williams H. Epidemic jaundice in New York State, 1921-1922. JAMA. 1923;80(8):532-4.  https://doi.org/10.1001/jama.1923.02640350014007 
Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Ruben+H+de+Kleine&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Kleine Ruben H</a>, <a href="/search?value1=Willem+S+Lexmond&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lexmond Willem S</a>, <a href="/search?value1=Gustav+Buescher&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Buescher Gustav</a>, <a href="/search?value1=Ekkehard+Sturm&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sturm Ekkehard</a>, <a href="/search?value1=Deidre+Kelly&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kelly Deidre</a>, <a href="/search?value1=Ansgar+W+Lohse&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lohse Ansgar W</a>, <a href="/search?value1=Dominic+Lenz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lenz Dominic</a>, <a href="/search?value1=Marianne+H%C3%B8rby+J%C3%B8rgensen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hørby Jørgensen Marianne</a>, <a href="/search?value1=on+behalf+of+the+contributors+to+the+survey&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the contributors to the survey</a></span>. Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(19):pii=2200369. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.19.2200369" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.19.2200369</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 29 Apr 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 12 May 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.19.2200369
/content/10.2807/1560-7917.ES.2022.27.19.2200369
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error