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Abstract

We assessed the protection conferred by naturally-acquired, vaccine-induced and hybrid immunity during the concomitant Omicron and Delta epidemic waves in France on symptomatic infection and severe COVID-19. The greatest levels of protection against both variants were provided by hybrid immunity. Protection against Omicron symptomatic infections was systematically lower and waned at higher speed than against Delta in those vaccinated. In contrast, there were little differences in variant-specific protection against severe inpatient outcomes in symptomatic individuals.

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/content/10.2807/1560-7917.ES.2022.27.16.2200250
2022-04-21
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2022.27.16.2200250
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Vaccine-induced and naturally-acquired protection against Omicron and Delta symptomatic infection and severe COVID-19 outcomes, France, December 2021 to January 2022
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Milena+Suarez+Castillo&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Suarez Castillo Milena</a>, <a href="/search?value1=Hamid+Khaoua&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Khaoua Hamid</a>, <a href="/search?value1=No%C3%A9mie+Courtejoie&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Courtejoie Noémie</a></span>. Vaccine-induced and naturally-acquired protection against Omicron and Delta symptomatic infection and severe COVID-19 outcomes, France, December 2021 to January 2022. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(16):pii=2200250. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.16.2200250" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.16.2200250</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 23 Mar 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 21 Apr 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.16.2200250
/content/10.2807/1560-7917.ES.2022.27.16.2200250
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