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Abstract

In August 2021, a man who has sex with men was diagnosed with HIV-1 infection despite using event-driven pre-exposure prophylaxis for over 2 years with self-reported excellent adherence. Sequencing identified resistance-associated mutations (RAM) M184V and K65R, conferring resistance to emtricitabine and tenofovir, and RAM V108I and E138A. Background RAM prevalence was two of 164 (1.2%) new HIV diagnoses in Amsterdam (2017–19). We reiterate the need for frequent HIV testing among PrEP users and additional testing in case of symptoms.

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/content/10.2807/1560-7917.ES.2022.27.14.2200275
2022-04-07
2024-12-22
/content/10.2807/1560-7917.ES.2022.27.14.2200275
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HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Jeffrey+CD+Koole&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koole Jeffrey CD</a>, <a href="/search?value1=Feline+de+la+Court&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de la Court Feline</a>, <a href="/search?value1=Matthijs+RA+Welkers&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Welkers Matthijs RA</a>, <a href="/search?value1=Kenneth+Yap&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yap Kenneth</a>, <a href="/search?value1=Janneke+E+Stalenhoef&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Stalenhoef Janneke E</a>, <a href="/search?value1=Suzanne+Jurriaans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jurriaans Suzanne</a>, <a href="/search?value1=Henry+JC+de+Vries&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Vries Henry JC</a>, <a href="/search?value1=Eline+LM+Op+de+Coul&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Op de Coul Eline LM</a>, <a href="/search?value1=Maria+Prins&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Prins Maria</a>, <a href="/search?value1=Elske+Hoornenborg&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoornenborg Elske</a></span>. HIV-1-infection in a man who has sex with men despite self-reported excellent adherence to pre-exposure prophylaxis, the Netherlands, August 2021: be alert to emtricitabine/tenofovir-resistant strain transmission. <a href="/content/ecdc">Euro Surveill.</a> 2022;27(14):pii=2200275. <a href="https://doi.org/10.2807/1560-7917.ES.2022.27.14.2200275" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2022.27.14.2200275</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 29 Mar 2022;&nbsp;&nbsp; <span class="generated">Accepted</span>: 06 Apr 2022 </span> </p>
/content/10.2807/1560-7917.ES.2022.27.14.2200275
/content/10.2807/1560-7917.ES.2022.27.14.2200275
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