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Abstract

The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.

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/content/10.2807/1560-7917.ES.2021.26.6.2100096
2021-02-11
2024-12-21
/content/10.2807/1560-7917.ES.2021.26.6.2100096
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Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Kamal+Abu+Jabal&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abu Jabal Kamal</a>, <a href="/search?value1=Hila+Ben-Amram&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ben-Amram Hila</a>, <a href="/search?value1=Karine+Beiruti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Beiruti Karine</a>, <a href="/search?value1=Yunis+Batheesh&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Batheesh Yunis</a>, <a href="/search?value1=Christian+Sussan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sussan Christian</a>, <a href="/search?value1=Salman+Zarka&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Zarka Salman</a>, <a href="/search?value1=Michael+Edelstein&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Edelstein Michael</a></span>. Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(6):pii=2100096. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.6.2100096" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.6.2100096</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Jan 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 10 Feb 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.6.2100096
/content/10.2807/1560-7917.ES.2021.26.6.2100096
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