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Abstract

Background

Toxoplasmosis during pregnancy can result in congenital anomalies or fetal death. Universal antenatal screening is recommended in France, a strategy in place since the 1970s.

Aim

We determined the seroprevalence of toxoplasmosis among pregnant women participating in the 2016 national perinatal survey (ENP), compared results with previous ENPs, and investigated factors associated with infection.

Methods

Using the 2016 ENP data, which contain sociodemographic and clinical information from all women giving birth during a one week period, we calculated adjusted prevalence ratios (aPR) by sociodemographic factors. Using available data from prior ENPs (1995, 2003 and 2010), we calculated age-standardised seroprevalences and aPRs for French women.

Results

In 2016, seroprevalence was 31.3% overall. Among French women, associations with increasing age (aPR: 1.54; 95% CI: 1.39–1.70), residence in Paris (aPR: 1.19; 95% CI: 1.08–1.31) or south-western regions (aPR: 1.19; 95% CI: 1.08–1.31), and higher professional status (aPR: 1.12; 95%CI 1.04–1.21) were observed. An association with increasing age was also evident among women from North Africa and sub-Saharan Africa. Age-standardised seroprevalence decreased from 55.0% in 1995 to 33.7% in 2016. Among French women, significant associations with age, Paris and south-west regions persisted across all ENPs.

Conclusion

Higher prevalences in older women may reflect a higher past risk of exposure while persistent geographical differences may reflect dietary or environmental differences. seroprevalence among pregnant women continues to fall and will impact screening effectiveness. This warrants a comprehensive review to determine the appropriate future of prevention in France.

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2021-02-04
2024-11-19
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.5.1900710
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National perinatal survey demonstrates a decreasing seroprevalence of Toxoplasma gondii infection among pregnant women in France, 1995 to 2016: impact for screening policy
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Eve+Robinson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Robinson Eve</a>, <a href="/search?value1=Henriette+de+Valk&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Valk Henriette</a>, <a href="/search?value1=Isabelle+Villena&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Villena Isabelle</a>, <a href="/search?value1=Yann+Le+Strat&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Le Strat Yann</a>, <a href="/search?value1=Mathieu+Tourdjman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Tourdjman Mathieu</a></span>. National perinatal survey demonstrates a decreasing seroprevalence of Toxoplasma gondii infection among pregnant women in France, 1995 to 2016: impact for screening policy. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(5):pii=1900710. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.5.1900710" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.5.1900710</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 19 Nov 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 13 Jul 2020 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.5.1900710
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