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Abstract

Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. We evaluated the sensitivity of AY.4.2 to neutralisation by sera from 30 Comirnaty (BNT162b2 mRNA) vaccine recipients in Denmark in November 2021. AY.4.2 neutralisation was comparable to other circulating Delta lineages or sub-lineages. Conversely, the less prevalent B.1.617.2 with E484K showed a significant more than 4-fold reduction in neutralisation that warrants surveillance of strains with the acquired E484K mutation.

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/content/10.2807/1560-7917.ES.2021.26.49.2101059
2021-12-09
2024-12-22
/content/10.2807/1560-7917.ES.2021.26.49.2101059
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Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Ria+Lassauni%C3%A8re&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lassaunière Ria</a>, <a href="/search?value1=Charlotta+Polacek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Polacek Charlotta</a>, <a href="/search?value1=Jannik+Fonager&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fonager Jannik</a>, <a href="/search?value1=Marc+Bennedb%C3%A6k&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bennedbæk Marc</a>, <a href="/search?value1=Lasse+Boding&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Boding Lasse</a>, <a href="/search?value1=Morten+Rasmussen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rasmussen Morten</a>, <a href="/search?value1=Anders+Fomsgaard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fomsgaard Anders</a></span>. Neutralisation of the SARS-CoV-2 Delta variant sub-lineages AY.4.2 and B.1.617.2 with the mutation E484K by Comirnaty (BNT162b2 mRNA) vaccine-elicited sera, Denmark, 1 to 26 November 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(49):pii=2101059. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.49.2101059" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.49.2101059</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 11 Nov 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 08 Dec 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.49.2101059
/content/10.2807/1560-7917.ES.2021.26.49.2101059
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