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Abstract

We evaluated routine testing with SARS-CoV-2 Delta variant-specific RT-PCR in regional hospital laboratories in addition to centralised national genomic surveillance in the Netherlands during June and July 2021. The increase of the Delta variant detected by RT-PCR correlated well with data from genomic surveillance and was available ca 2 weeks earlier. This rapid identification of the relative abundance and increase of SARS-CoV-2 variants of concern may have important benefits for implementation of local public health measures.

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/content/10.2807/1560-7917.ES.2021.26.40.2100921
2021-10-07
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.40.2100921
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References

  1. Banada P, Green R, Banik S, Chopoorian A, Streck D, Jones R, et al. A simple RT-PCR melting temperature assay to rapidly screen for widely circulating SARS-CoV-2 variants. medRxiv. 2021;JCM0084521. PMID: 33758892 
  2. Ong DSY, Koeleman JGM, Vaessen N, Breijer S, Paltansing S, de Man P. Rapid screening method for the detection of SARS-CoV-2 variants of concern. J Clin Virol. 2021;141:104903.  https://doi.org/10.1016/j.jcv.2021.104903  PMID: 34182300 
  3. Harvey WT, Carabelli AM, Jackson B, Gupta RK, Thomson EC, Harrison EM, et al. SARS-CoV-2 variants, spike mutations and immune escape. Nat Rev Microbiol. 2021;19(7):409-24.  https://doi.org/10.1038/s41579-021-00573-0  PMID: 34075212 
  4. World Health Organization (WHO). Tracking SARS-CoV-2 variants. Geneva: WHO. [Accessed: 06 Oct 2021]. Available from: https://www.who.int/en/activities/tracking-SARS-CoV-2-variants
  5. Oude Munnink BB, Worp N, Nieuwenhuijse DF, Sikkema RS, Haagmans B, Fouchier RAM, et al. The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology. Nat Med. 2021;27(9):1518-24.  https://doi.org/10.1038/s41591-021-01472-w  PMID: 34504335 
  6. Kustin T, Harel N, Finkel U, Perchik S, Harari S, Tahor M, et al. Evidence for increased breakthrough rates of SARS-CoV-2 variants of concern in BNT162b2-mRNA-vaccinated individuals. Nat Med. 2021;27(8):1379-84.  https://doi.org/10.1038/s41591-021-01413-7  PMID: 34127854 
  7. Luo CH, Morris CP, Sachithanandham J, Amadi A, Gaston D, Li M, Swanson NJ, Schwartz M, Klein EY, Pekosz A, Mostafa HH. Infection with the SARS-CoV-2 delta variant is associated with higher infectious virus loads compared to the alpha variant in both unvaccinated and vaccinated individuals. medRxiv. 2021 Aug 20:2021.08.15.21262077.
  8. Geers D, Shamier MC, Bogers S, den Hartog G, Gommers L, Nieuwkoop NN, et al. SARS-CoV-2 variants of concern partially escape humoral but not T-cell responses in COVID-19 convalescent donors and vaccines. Sci Immunol. 2021;6(59):eabj1750.  PMID: 34035118 
  9. Davies NG, Abbott S, Barnard RC, Jarvis CI, Kucharski AJ, Munday JD, et al. Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England. Science. 2021;372(6538):eabg3055.  https://doi.org/10.1126/science.abg3055  PMID: 33658326 
  10. van der Vries E, Jonges M, Herfst S, Maaskant J, Van der Linden A, Guldemeester J, et al. Evaluation of a rapid molecular algorithm for detection of pandemic influenza A (H1N1) 2009 virus and screening for a key oseltamivir resistance (H275Y) substitution in neuraminidase. J Clin Virol. 2010;47(1):34-7.  https://doi.org/10.1016/j.jcv.2009.09.030  PMID: 19857993 
Supplementing SARS-CoV-2 genomic surveillance with PCR-based variant detection for real-time actionable information, the Netherlands, June to July 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Richard+Molenkamp&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Molenkamp Richard</a>, <a href="/search?value1=Ewout+Fanoy&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fanoy Ewout</a>, <a href="/search?value1=Leonie+Derickx&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Derickx Leonie</a>, <a href="/search?value1=Theun+de+Groot&option1=author&noRedirect=true" class="nonDisambigAuthorLink">de Groot Theun</a>, <a href="/search?value1=Marcel+Jonges&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Jonges Marcel</a>, <a href="/search?value1=Tjalling+Leenstra&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Leenstra Tjalling</a>, <a href="/search?value1=Roel+Nijhuis&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nijhuis Roel</a>, <a href="/search?value1=Suzan+Pas&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pas Suzan</a>, <a href="/search?value1=Ali+Vahidnia&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Vahidnia Ali</a>, <a href="/search?value1=Christian+von+Wintersdorff&option1=author&noRedirect=true" class="nonDisambigAuthorLink">von Wintersdorff Christian</a>, <a href="/search?value1=Bert+Mulder&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mulder Bert</a>, <a href="/search?value1=Marion+Koopmans&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koopmans Marion</a></span>. Supplementing SARS-CoV-2 genomic surveillance with PCR-based variant detection for real-time actionable information, the Netherlands, June to July 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(40):pii=2100921. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.40.2100921" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.40.2100921</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 21 Sept 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 06 Oct 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.40.2100921
/content/10.2807/1560-7917.ES.2021.26.40.2100921
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