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Abstract

Through deterministic data linkage of health registries, mRNA vaccine effectiveness (VE) against COVID-19-related hospitalisations and deaths was measured in 1,880,351 older adults. VE against hospitalisations was 94% (95% confidence interval (CI): 88–97) and 82% (95% CI: 72–89) for those 65–79 and ≥ 80 years old, with no evidence of waning 98 days after dose two. VE against mortality was 96% (95% CI: 92–98) and 81% (95% CI: 74–87) in these two age groups.

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/content/10.2807/1560-7917.ES.2021.26.38.2100833
2021-09-23
2024-12-22
/content/10.2807/1560-7917.ES.2021.26.38.2100833
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References

  1. Administração Central do Sistema de Saúde (ACSS). SDM - BI de Conceitos. [Metainformation - Concept Specification]. Lisbon: ACSS. [Accessed: 27 Aug 2021]. Portuguese Available from: https://sdm.min-saude.pt/bi.aspx?id_con=90
  2. Administração Central do Sistema de Saúde (ACSS). Circular normativa Codificação clínica de doentes internados com diagnóstico de COVID-19. [Normative Circular: Clinical coding of hospitalized patients diagnosed with COVID-19]. Lisbon: ACSS; 2021. Portuguese. Available from: http://www.acss.min-saude.pt/wp-content/uploads/2020/05/Circular-Normativa-5_2020_Codif-Covid-19.pdf
  3. Chung H, He S, Nasreen S, Sundaram ME, Buchan SA, Wilson SE, et al. Effectiveness of BNT162b2 and mRNA-1273 covid-19 vaccines against symptomatic SARS-CoV-2 infection and severe covid-19 outcomes in Ontario, Canada: test negative design study. BMJ. 2021;374:n1943.  https://doi.org/10.1136/bmj.n1943  PMID: 34417165 
  4. Ribeiro AI, Launay L, Guillaume E, Launoy G, Barros H. The Portuguese version of the European Deprivation Index: Development and association with all-cause mortality. PLoS One. 2018;13(12):e0208320.  https://doi.org/10.1371/journal.pone.0208320  PMID: 30517185 
  5. Vasileiou E, Simpson CR, Shi T, Kerr S, Agrawal U, Akbari A, et al. Interim findings from first-dose mass COVID-19 vaccination roll-out and COVID-19 hospital admissions in Scotland: a national prospective cohort study. Lancet. 2021;397(10285):1646-57.  https://doi.org/10.1016/S0140-6736(21)00677-2  PMID: 33901420 
  6. Tenforde MW, Olson SM, Self WH, Talbot HK, Lindsell CJ, Steingrub JS, et al. Effectiveness of Pfizer-BioNTech and Moderna vaccines against COVID-19 among hospitalized adults aged ≥65 years - United States, January-March 2021. MMWR Morb Mortal Wkly Rep. 2021;70(18):674-9.  https://doi.org/10.15585/mmwr.mm7018e1  PMID: 33956782 
  7. Haas EJ, Angulo FJ, McLaughlin JM, Anis E, Singer SR, Khan F, et al. Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet. 2021;397(10287):1819-29.  https://doi.org/10.1016/S0140-6736(21)00947-8  PMID: 33964222 
  8. Instituto Nacional de Saúde Doutor Ricardo Jorge (INSA). Diversidade genética do novo coronavírus SARS-CoV-2 (COVID-19) em Portugal. [Genetic diversity of the novel coronavirus SARS-CoV-2 (COVID-19) in Portugal]. Lisbon: INSA; 2021. Portuguese. Available from: https://insaflu.insa.pt/covid19
  9. Tenforde MW, Self WH, Naioti EA, Ginde AA, Douin DJ, Olson SM, et al. Sustained effectiveness of Pfizer-BioNTech and Moderna vaccines against COVID-19 associated hospitalizations among adults - United States, March-July 2021. MMWR Morb Mortal Wkly Rep. 2021;70(34):1156-62.  https://doi.org/10.15585/mmwr.mm7034e2  PMID: 34437524 
  10. Instituto Nacional de Estatística (INE). População residente (N.o) por Local de residência (NUTS - 2013), Sexo e Grupo etário; Anual - INE, Estimativas anuais da população residente. [Resident population (No.) by place of residence (NUTS - 2013), sex and age group; annual - Statistics Portugal, annual estimates of resident population]. Lisbon: INE. [Accessed: 27 Aug 2021]. Portuguese. Available from: https://www.ine.pt/xportal/xmain?xpid=INE&xpgid=ine_indicadores&indOcorrCod=0008273
mRNA vaccine effectiveness against COVID-19-related hospitalisations and deaths in older adults: a cohort study based on data linkage of national health registries in Portugal, February to August 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Baltazar+Nunes&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nunes Baltazar</a>, <a href="/search?value1=Ana+Paula+Rodrigues&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rodrigues Ana Paula</a>, <a href="/search?value1=Irina+Kislaya&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Kislaya Irina</a>, <a href="/search?value1=Camila+Cruz&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cruz Camila</a>, <a href="/search?value1=Andr%C3%A9+Peralta-Santos&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Peralta-Santos André</a>, <a href="/search?value1=Jo%C3%A3o+Lima&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lima João</a>, <a href="/search?value1=Pedro++Pinto+Leite&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pinto Leite Pedro </a>, <a href="/search?value1=Duarte+Sequeira&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sequeira Duarte</a>, <a href="/search?value1=Carlos++Matias+Dias&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Matias Dias Carlos </a>, <a href="/search?value1=Ausenda+Machado&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Machado Ausenda</a></span>. mRNA vaccine effectiveness against COVID-19-related hospitalisations and deaths in older adults: a cohort study based on data linkage of national health registries in Portugal, February to August 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(38):pii=2100833. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.38.2100833" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.38.2100833</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 27 Aug 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 22 Sept 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.38.2100833
/content/10.2807/1560-7917.ES.2021.26.38.2100833
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