1887
  1. Home
  2. Eurosurveillance
  3. Volume 26, Issue 38, 23/Sep/2021
  4. Article
Research Open Access
Like 0
Download

Abstract

Background

Despite the availability of highly effective direct-acting antivirals (DAAs) and the expected treatment as prevention (TasP) effect, transmission of hepatitis C virus (HCV) persists in men who have sex with men (MSM) who engage in high-risk sexual behaviours.

Aim

We aimed to estimate the incidence of primary HCV infection among MSM living with HIV in France when DAA was readily available.

Methods

We used data from a large French hospital cohort of persons living with HIV (ANRS CO4-FHDH) prospectively collected between 2014 and 2017. HCV incidence rates were calculated using person-time methods for HCV-negative MSM at inclusion who had serological follow-up from 1 January 2014 to 31 December 2017. Sensitivity analyses were performed by varying the main assumptions to assess their impact on the results.

Results

Of 14,273 MSM living with HIV who were initially HCV-seronegative, 330 acquired HCV during follow-up over 45,866 person-years (py), resulting in an overall estimated incidence rate of 0.72/100 py (95% CI: 0.65–0.80). HCV incidence significantly decreased from 0.98/100 py (95% CI: 0.81–1.19) in 2014 to 0.45/100 py (95% CI: 0.35–0.59) in 2017 (54% decrease; 95% CI: 36–67). This trend was confirmed by most of the sensitivity analyses.

Conclusion

The primary incidence of HCV was halved for MSM living with HIV between 2014 and 2017. This decrease may be related to unrestricted DAA availability in France for individuals living with HIV. Further interventions, including risk reduction, are needed to reach HCV micro-elimination in MSM living with HIV.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2021.26.38.2001321
2021-09-23
2024-11-21
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.38.2001321
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/26/38/eurosurv-26-38-3.html?itemId=/content/10.2807/1560-7917.ES.2021.26.38.2001321&mimeType=html&fmt=ahah

References

  1. Hagan H, Jordan AE, Neurer J, Cleland CM. Incidence of sexually transmitted hepatitis C virus infection in HIV-positive men who have sex with men. AIDS. 2015;29(17):2335-45.  https://doi.org/10.1097/QAD.0000000000000834  PMID: 26258525 
  2. van der Helm JJ, Prins M, del Amo J, Bucher HC, Chêne G, Dorrucci M, et al. , CASCADE Collaboration. The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007. AIDS. 2011;25(8):1083-91.  https://doi.org/10.1097/QAD.0b013e3283471cce  PMID: 21537114 
  3. van de Laar T, Pybus O, Bruisten S, Brown D, Nelson M, Bhagani S, et al. Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology. 2009;136(5):1609-17.  https://doi.org/10.1053/j.gastro.2009.02.006  PMID: 19422083 
  4. van Santen DK, van der Helm JJ, Del Amo J, Meyer L, D’Arminio Monforte A, Price M, et al. , CASCADE Collaboration in EuroCoord. Lack of decline in hepatitis C virus incidence among HIV-positive men who have sex with men during 1990-2014. J Hepatol. 2017;67(2):255-62.  https://doi.org/10.1016/j.jhep.2017.03.038  PMID: 28412290 
  5. Larsen C, Chaix M-L, Le Strat Y, Velter A, Gervais A, Aupérin I, et al. , steering committee of the HEPAIG study. Gaining greater insight into HCV emergence in HIV-infected men who have sex with men: the HEPAIG Study. PLoS One. 2011;6(12):e29322.  https://doi.org/10.1371/journal.pone.0029322  PMID: 22216248 
  6. Vanhommerig JW, Lambers FAE, Schinkel J, Geskus RB, Arends JE, van de Laar TJW, et al. , MOSAIC (MSM Observational Study of Acute Infection With Hepatitis C) Study Group. Risk factors for sexual transmission of hepatitis C Virus among human immunodeficiency virus-infected men who have sex with men: a case-control study. Open Forum Infect Dis. 2015;2(3):ofv115.  https://doi.org/10.1093/ofid/ofv115  PMID: 26634219 
  7. Danta M, Brown D, Bhagani S, Pybus OG, Sabin CA, Nelson M, et al. , HIV and Acute HCV (HAAC) group. Recent epidemic of acute hepatitis C virus in HIV-positive men who have sex with men linked to high-risk sexual behaviours. AIDS. 2007;21(8):983-91.  https://doi.org/10.1097/QAD.0b013e3281053a0c  PMID: 17457092 
  8. Urbanus AT, van de Laar TJ, Stolte IG, Schinkel J, Heijman T, Coutinho RA, et al. Hepatitis C virus infections among HIV-infected men who have sex with men: an expanding epidemic. AIDS. 2009;23(12):F1-7.  https://doi.org/10.1097/QAD.0b013e32832e5631  PMID: 19542864 
  9. van de Laar TJW, Matthews GV, Prins M, Danta M. Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection. AIDS. 2010;24(12):1799-812.  https://doi.org/10.1097/QAD.0b013e32833c11a5  PMID: 20601854 
  10. Thein H-H, Yi Q, Dore GJ, Krahn MD. Natural history of hepatitis C virus infection in HIV-infected individuals and the impact of HIV in the era of highly active antiretroviral therapy: a meta-analysis. AIDS. 2008;22(15):1979-91.  https://doi.org/10.1097/QAD.0b013e32830e6d51  PMID: 18784461 
  11. Morlat P. Prise en charge médicale des personnes vivant avec le VIH. Actualisation 2015 du rapport 2013. [French guidelines on medical care of people living with HIV. 2015 update of 2013 record]. Paris: Conseil national du sida et des hépatites virales. [Accessed: 8 Apr 2020]. French. Available from: https://cns.sante.fr/wp-content/uploads/2015/10/experts-vih_actualisation2015.pdf
  12. Ryom L, Boesecke C, Gisler V, Manzardo C, Rockstroh JK, Puoti M, et al. , EACS Governing Board. Essentials from the 2015 European AIDS Clinical Society (EACS) guidelines for the treatment of adult HIV-positive persons. HIV Med. 2016;17(2):83-8.  https://doi.org/10.1111/hiv.12322  PMID: 26548563 
  13. Bischoff J, Rockstroh JK. Are there any challenges left in hepatitis C virus therapy of HIV-infected patients? Int J Antimicrob Agents. 2020;56(1):105527.  https://doi.org/10.1016/j.ijantimicag.2018.08.019  PMID: 30145247 
  14. Sikavi C, Chen PH, Lee AD, Saab EG, Choi G, Saab S. Hepatitis C and human immunodeficiency virus coinfection in the era of direct-acting antiviral agents: No longer a difficult-to-treat population. Hepatology. 2018;67(3):847-57.  https://doi.org/10.1002/hep.29642  PMID: 29108121 
  15. World Health Organization (WHO). Global health sector strategy on viral hepatitis 2016-2021, towards ending viral hepatitis. Geneva: WHO. 2016. Available from: https://apps.who.int/iris/bitstream/handle/10665/246177/WHO-HIV-2016.06-eng.pdf
  16. Comité interministériel pour la santé. Priorité prévention: rester en bonne santé tout au long de sa vie, 2018-2022. [Prevention priority: stay healthy throughout life, 2018-2022]. Paris: Ministère des Solidarités et de la Santé. 2018. French. Available from: https://solidarites-sante.gouv.fr/IMG/pdf/plan_national_de_sante_publique__psnp.pdf
  17. Dessauce C, Semenzato L, Rachas A, Barthélémy P, Lavin L, Comboroure J-C, et al. Direct-acting antivirals in the treatment of chronic hepatitis C: overview of 4 years of coverage by the French health insurance (January 2014-December 2017). Bull Epidemiol Hebd (Paris). 2019;24-25:502-9.
  18. Mary-Krause M, Grabar S, Lièvre L, Abgrall S, Billaud E, Boué F, et al. Cohort Profile: French hospital database on HIV (FHDH-ANRS CO4). Int J Epidemiol. 2014;43(5):1425-36.  https://doi.org/10.1093/ije/dyu002  PMID: 24550249 
  19. Fournier AL, Yazdanpanah Y, Verdon R, Lariven S, Mackoumbou-Nkouka C, Phung B-C, et al. Incidence of and risk factors for medical care interruption in people living with HIV in recent years. Yotebieng M, editor. PLoS ONE. 2019 Mar 13;14(3):e0213526.
  20. Association Française pour l’Étude du Foie (AFEF). Recommandations AFEF pour l’élimination de l’infection par le virus de l’hépatite C en France. [French hepatology society’s recommendations for HCV infection elimination in France]. 2018. Paris: AFEF. French. Available from: https://afef.asso.fr/wp-content/uploads/2018/06/VF-INTERACTIF-RECO-VHC-AFEF-v2103.pdf
  21. Boerekamps A, van den Berk GE, Lauw FN, Leyten EM, van Kasteren ME, van Eeden A, et al. Declining hepatitis C virus (HCV) incidence in Dutch human immunodeficiency virus-positive men who have sex with men after unrestricted access to HCV therapy. Clin Infect Dis. 2018;66(9):1360-5.  https://doi.org/10.1093/cid/cix1007  PMID: 29186320 
  22. Visseaux B, Hué S, Le Hingrat Q, Salmona M, Lebourgeois S, Delaugerre C, et al. Phylogenetic investigation of HCV-4d epidemic in Paris MSM HIV population reveals a still active outbreak and a strong link to the Netherlands. Clin Microbiol Infect. 2020;26(6):785.e1-4.  https://doi.org/10.1016/j.cmi.2020.01.034  PMID: 32035235 
  23. Garvey LJ, Cooke GS, Smith C, Stingone C, Ghosh I, Dakshina S, et al. Decline in hepatitis C virus (HCV) incidence in men who have sex with men living with human immunodeficiency virus: progress to HCV microelimination in the United Kingdom?. Clin Infect Dis. 2020;ciaa021
  24. Champenois K, Seng R, Persoz A, Essat A, Gaud C, Laureillard D, et al. , ANRS PRIMO cohort study group. Calendar trends in sexual behaviours in a cohort of HIV-infected MSM at the era of treatment as prevention of HIV infection. AIDS. 2018;32(13):1871-9.  https://doi.org/10.1097/QAD.0000000000001916  PMID: 29927787 
  25. Roth JA, Franzeck FC, Balakrishna S, Lautenschlager S, Thurnheer MC, Trellu LT, et al. Repeated syphilis episodes in HIV-infected men who have sex with men: a multicenter prospective cohort study on risk factors and the potential role of syphilis immunity. Open Forum Infect Dis. 2020;7(1):ofaa019.
  26. Castry M, Cousien A, Supervie V, Velter A, Ghosn J, Paltiel AD, et al. Impact of test-and-treat and risk reduction strategies on HCV transmission among MSM living with HIV in France: a modelling approach. Gut. 2020;gutjnl-2020-321744.  PMID: 33109688 
  27. Pradat P, Huleux T, Raffi F, Delobel P, Valantin M-A, Poizot-Martin I, et al. , Dat’AIDS study Group. Incidence of new hepatitis C virus infection is still increasing in French MSM living with HIV. AIDS. 2018;32(8):1077-82.  https://doi.org/10.1097/QAD.0000000000001789  PMID: 29438195 
  28. Cotte L, Cua E, Reynes J, Raffi F, Rey D, Delobel P, et al. , Dat’AIDS study Group. Hepatitis C virus incidence in HIV-infected and in preexposure prophylaxis (PrEP)-using men having sex with men. Liver Int. 2018;38(10):1736-40.  https://doi.org/10.1111/liv.13922  PMID: 29959866 
  29. Ramière C, Charre C, Miailhes P, Bailly F, Radenne S, Uhres A-C, et al. , Lyon Acute Hepatitis Study Group. Patterns of hepatitis C virus transmission in human immunodeficiency virus (HIV)–infected and HIV-negative men who have sex with men. Clin Infect Dis. 2019;69(12):2127-35.  https://doi.org/10.1093/cid/ciz160  PMID: 30810158 
  30. Gras J, Mahjoub N, Charreau I, Cotte L, Tremblay C, Chas J, et al. , IPERGAY Study Group. Early diagnosis and risk factors of acute hepatitis C in high-risk MSM on preexposure prophylaxis. AIDS. 2020;34(1):47-52.  https://doi.org/10.1097/QAD.0000000000002364  PMID: 31789889 
  31. Hoornenborg E, Coyer L, Boyd A, Achterbergh RCA, Schim van der Loeff MF, Bruisten S, et al. , Amsterdam PrEP Project team in the HIV Transmission Elimination AMsterdam (H-TEAM) Initiative. High incidence of HCV in HIV-negative men who have sex with men using pre-exposure prophylaxis. J Hepatol. 2020;72(5):855-64.  https://doi.org/10.1016/j.jhep.2019.11.022  PMID: 31862485 
  32. Nguyen T, Delaugerre C, Valantin M-A, Amiel C, Netzer E. Lʼyavanc T, et al. Shared HCV transmission networks among HIV-1-positive and HIV-1-negative men having sex with men by ultradeep sequencing. J Acquir Immune Defic Syndr. 2019;82(1):105-10.  PMID: 31169768 
  33. Lau B, Gange SJ, Moore RD. Interval and clinical cohort studies: epidemiological issues. AIDS Res Hum Retroviruses. 2007;23(6):769-76.  https://doi.org/10.1089/aid.2006.0171  PMID: 17604539 
Hepatitis C virus (HCV) incidence among men who have sex with men (MSM) living with HIV: results from the French Hospital Database on HIV (ANRS CO4-FHDH) cohort study, 2014 to 2017
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Mathieu+Castry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Castry Mathieu</a>, <a href="/search?value1=Anthony+Cousien&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cousien Anthony</a>, <a href="/search?value1=Jonathan+Bellet&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bellet Jonathan</a>, <a href="/search?value1=Karen+Champenois&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Champenois Karen</a>, <a href="/search?value1=Gilles+Pialoux&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pialoux Gilles</a>, <a href="/search?value1=Yazdan+Yazdanpanah&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Yazdanpanah Yazdan</a>, <a href="/search?value1=Dominique+Costagliola&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Costagliola Dominique</a>, <a href="/search?value1=Sophie+Grabar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Grabar Sophie</a>, <a href="/search?value1=Sylvie+Deuffic-Burban&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Deuffic-Burban Sylvie</a>, <a href="/search?value1=on+behalf+of+the+French+Hospital+Database+on+HIV+%28ANRS+CO4-FHDH+Cohort%29&option1=author&noRedirect=true" class="nonDisambigAuthorLink">on behalf of the French Hospital Database on HIV (ANRS CO4-FHDH Cohort)</a></span>. Hepatitis C virus (HCV) incidence among men who have sex with men (MSM) living with HIV: results from the French Hospital Database on HIV (ANRS CO4-FHDH) cohort study, 2014 to 2017. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(38):pii=2001321. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.38.2001321" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.38.2001321</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 01 Jul 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 26 Feb 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.38.2001321
/content/10.2807/1560-7917.ES.2021.26.38.2001321
Loading

Data & Media loading...

Supplementary data

Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error