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Abstract

We compared PCR results from SARS-CoV-2-positive patients tested in the community in France from 14 June to 30 July 2021. In asymptomatic individuals, Cq values were significantly higher in fully vaccinated than non-fully vaccinated individuals (effect size: 1.7; 95% CI: 1–2.3; p < 10−6). In symptomatic individuals and controlling for time since symptoms, the difference vanished (p = 0.26). Infections with the Delta variant had lower Cq values at symptom onset than with Alpha (effect size: −3.32; 95% CI: −4.38 to −2.25; p < 10−6).

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Authors’ correction for Euro Surveill. 2021;26(37)
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2021-09-16
2024-11-23
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.37.2100824
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References

  1. Campbell F, Archer B, Laurenson-Schafer H, Jinnai Y, Konings F, Batra N, et al. Increased transmissibility and global spread of SARS-CoV-2 variants of concern as at June 2021. Euro Surveill. 2021;26(24):2100509.  https://doi.org/10.2807/1560-7917.ES.2021.26.24.2100509  PMID: 34142653 
  2. Mlcochova P, Kemp S, Dhar MS, Papa G, Meng B, Ferreira IATM, et al. SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. Nature. 2021.  https://doi.org/10.1038/s41586-021-03944-y  PMID: 34488225 
  3. Alizon S, Haim-Boukobza S, Foulongne V, Verdurme L, Trombert-Paolantoni S, Lecorche E, et al. Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021. Euro Surveill. 2021;26(28):2100573.  https://doi.org/10.2807/1560-7917.ES.2021.26.28.2100573  PMID: 34269174 
  4. Fisman DN, Tuite AR. Progressive increase in virulence of novel SARS-CoV-2 variants in Ontario, Canada. medRxiv 2021.07.05.21260050. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.07.05.21260050 
  5. Ong SWX, Chiew CJ, Ang LW, Mak T-M, Cui L, Toh MPHS, et al. Clinical and virological features of SARS-CoV-2 variants of concern: a retrospective cohort study comparing B.1.1.7 (Alpha), B.1.315 (Beta), and B.1.617.2 (Delta). Clin Infect Dis. 2021;ciab721. PMID: 34423834 
  6. Sheikh A, McMenamin J, Taylor B, Robertson C, Public Health Scotland and the EAVE II Collaborators. SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness. Lancet. 2021;397(10293):2461-2.  https://doi.org/10.1016/S0140-6736(21)01358-1  PMID: 34139198 
  7. Lopez Bernal J, Andrews N, Gower C, Gallagher E, Simmons R, Thelwall S, et al. Effectiveness of Covid-19 Vaccines against the B.1.617.2 (Delta) Variant. N Engl J Med. 2021;385(7):585-94.  https://doi.org/10.1056/NEJMoa2108891  PMID: 34289274 
  8. Brown CM, Vostok J, Johnson H, Burns M, Gharpure R, Sami S, et al. Outbreak of SARS-CoV-2 infections, including COVID-19 vaccine breakthrough infections, associated with large public gatherings - Barnstable County, Massachusetts, July 2021. MMWR Morb Mortal Wkly Rep. 2021;70(31):1059-62.  https://doi.org/10.15585/mmwr.mm7031e2  PMID: 34351882 
  9. Public Health England (PHE). SARS-CoV-2 variants of concern and variants under investigation in England. Technical briefing 20. London: PHE; 2021. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/1009243/Technical_Briefing_20.pdf
  10. Elliott P, Haw D, Wang H, Eales O, Walters CE, Ainslie KEC, et al. REACT-1 round 13 final report: Exponential growth, high prevalence of SARS-CoV-2 and vaccine effectiveness associated with Delta variant in England during May to July 2021. London: Imperial College; 2021. Available from: https://spiral.imperial.ac.uk/bitstream/10044/1/90800/2/react1_r13_final_preprint_final.pdf
  11. Chia PY, Ong S, Chiew CJ, Ang LW, Chavatte JG, Mak TM, et al. Virological and serological kinetics of SARS-CoV-2 Delta variant vaccine-breakthrough infections: A multi-center cohort study. medRxiv. 2021.07.28.21261295. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.07.28.21261295 
  12. Alizon S, Selinger C, Sofonea MT, Haim-Boukobza S, Giannoli J-M, Ninove L, et al. Epidemiological and clinical insights from SARS-CoV-2 RT-PCR cycle amplification values. medRxiv. 2021.03.15.21253653. Preprint. http://dx.doi.org/  https://doi.org/10.1101/2021.03.15.21253653 
  13. Hay JA, Kennedy-Shaffer L, Kanjilal S, Lennon NJ, Gabriel SB, Lipsitch M, et al. Estimating epidemiologic dynamics from cross-sectional viral load distributions. Science. 2021;373(6552):eabh0635.  https://doi.org/10.1126/science.abh0635  PMID: 34083451 
  14. Cosentino G, Bernard M, Ambroise J, Giannoli J-M, Guedj J, Débarre F, et al. SARS-CoV-2 viral dynamics in infections with Alpha and Beta variants of concern in the French community. J Infect. 2021;S0163-44532100374-1. PMID: 34329672 
  15. Althaus CL, Baggio S, Reichmuth ML, Hodcroft EB, Riou J, Neher RA, et al. A tale of two variants: Spread of SARS-CoV-2 variants Alpha in Geneva, Switzerland, and Beta in South Africa. medRxiv. 2021.06.10.21258468. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.06.10.21258468 
  16. Hay JA, Kennedy-Shaffer L, Mina MJ. Viral loads observed under competing strain dynamics. medRxiv. 2021.07.27.21261224. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.07.27.21261224 
  17. Santé Publique France. Données relatives aux personnes vaccinées contre la Covid-19. [Data relating to people vaccinated against Covid-19]. Paris: French Government. [Accessed: 2021-08-09]. French. Available from: https://www.data.gouv.fr/en/datasets/donnees-relatives-aux-personnes-vaccinees-contre-la-covid-19-1/
  18. Kissler SM, Fauver JR, Mack C, Tai CG, Breban MI, Watkins AE, et al. Viral dynamics of SARS-CoV-2 variants in vaccinated and unvaccinated individuals. medRxiv. 2021.02.16.21251535. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.02.16.21251535 
  19. Lee LYW, Rozmanowski S, Pang M, Charlett A, Anderson C, Hughes GJ, et al. SARS-CoV-2 infectivity by viral load, S gene variants and demographic factors and the utility of lateral flow devices to prevent transmission. Clin Infect Dis. 2021;ciab421. PMID: 33972994 
  20. Marc A, Kerioui M, Blanquart F, Bertrand J, Mitjà O, Corbacho-Monné M, et al. Quantifying the relationship between SARS-CoV-2 viral load and infectiousness. medRxiv. 2021.05.07.21256341. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.05.07.21256341 
  21. Lyngse FP, Mølbak K, Træholt Franck K, Nielsen C, Skov RL, Voldstedlund M, et al. Association between SARS-CoV-2 transmissibility, viral load, and age in households. medRxiv. 2021.02.28.21252608. Preprint. http://dx.doi.org/ https://doi.org/10.1101/2021.02.28.21252608 
Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Fran%C3%A7ois+Blanquart&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Blanquart François</a>, <a href="/search?value1=Cl%C3%A9mence+Abad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Abad Clémence</a>, <a href="/search?value1=Jo%C3%ABvin+Ambroise&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ambroise Joëvin</a>, <a href="/search?value1=Mathieu+Bernard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Bernard Mathieu</a>, <a href="/search?value1=Gina+Cosentino&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Cosentino Gina</a>, <a href="/search?value1=Jean-Marc+Giannoli&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Giannoli Jean-Marc</a>, <a href="/search?value1=Florence+D%C3%A9barre&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Débarre Florence</a></span>. Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(37):pii=2100824. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.37.2100824" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.37.2100824</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 25 Aug 2021 </span> </p>
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/content/10.2807/1560-7917.ES.2021.26.37.2100824
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