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Abstract

On 1 May 2018, a pertussis outbreak was declared and widespread vaccination recommended at an all-female secondary boarding school in southern England. We conducted a retrospective cohort study to determine the extent of pertussis transmission and identify risk factors in this semi-closed population. Of 504 students and staff assessed before post-exposure vaccination, 48% (n = 240) had evidence of pertussis. A sub-analysis of 409 students found that both residential dormitory (p = 0.05) and school year (p = 0.03) were associated with pertussis, with odds decreasing by 11% for each increase in school year (95% confidence interval: 0.7–20.2). Odds of pertussis were 1.7 times higher in those assumed to have received acellular vaccines for their primary course compared with those assumed to have received whole-cell vaccines (based on date of birth), although this difference was not significant (p = 0.12). Our findings support the need for timely, widespread vaccination following identification of cases among adolescents in a semi-closed United Kingdom (UK) setting and to review the evidence for the introduction of an adolescent pertussis booster to the UK routine vaccination programme.

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/content/10.2807/1560-7917.ES.2021.26.26.1900736
2021-07-01
2024-12-21
/content/10.2807/1560-7917.ES.2021.26.26.1900736
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Retrospective cohort study investigating extent of pertussis transmission during a boarding school outbreak, England, December 2017 to June 2018
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Matt+Edmunds&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Edmunds Matt</a>, <a href="/search?value1=Rachel+Mearkle&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mearkle Rachel</a>, <a href="/search?value1=Jennifer+Folliard&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Folliard Jennifer</a>, <a href="/search?value1=Charlotte+Anderson&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Anderson Charlotte</a>, <a href="/search?value1=Sooria+Balasegaram&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Balasegaram Sooria</a>, <a href="/search?value1=Nastassya+Chandra&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Chandra Nastassya</a>, <a href="/search?value1=Clare+Sawyer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Sawyer Clare</a>, <a href="/search?value1=Norman+K+Fry&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fry Norman K</a>, <a href="/search?value1=Sonia+Ribeiro&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ribeiro Sonia</a>, <a href="/search?value1=Gemma+Palmer&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Palmer Gemma</a>, <a href="/search?value1=Michael+Morgan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Morgan Michael</a>, <a href="/search?value1=Gill+Underhill&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Underhill Gill</a>, <a href="/search?value1=Nusreen+Ahmad&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ahmad Nusreen</a>, <a href="/search?value1=Simon+Friar&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Friar Simon</a>, <a href="/search?value1=Andre+Charlett&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Charlett Andre</a>, <a href="/search?value1=David+Litt&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Litt David</a>, <a href="/search?value1=Colin+S+Brown&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brown Colin S</a>, <a href="/search?value1=Gayatri+Amirthalingam&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Amirthalingam Gayatri</a></span>. Retrospective cohort study investigating extent of pertussis transmission during a boarding school outbreak, England, December 2017 to June 2018. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(26):pii=1900736. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.26.1900736" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.26.1900736</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 03 Dec 2019;&nbsp;&nbsp; <span class="generated">Accepted</span>: 11 Mar 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.26.1900736
/content/10.2807/1560-7917.ES.2021.26.26.1900736
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