1887
  1. Home
  2. Eurosurveillance
  3. Volume 26, Issue 18, 06/May/2021
  4. Article
Rapid communication Open Access
Like 0
Download

Abstract

We describe four SARS-CoV-2 re-infections with a B.1.351 variant in 2021, in healthcare workers (HCWs) previously infected in 2020, before detection of this variant in Europe. Cases live in France, near the border with Luxembourg, where variants B.1.351 and B.1.1.7 circulated. All work in the same hospital unit where a cluster of COVID 19 with B1.351 variant occurred, affecting patients and HCWs. Before the cluster onset, HCWs used surgical masks, as per recommendations. After cluster onset, HCWs used FFP2 masks.

© Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Loading

Article metrics loading...

/content/10.2807/1560-7917.ES.2021.26.18.2100423
2021-05-06
2024-12-21
/content/10.2807/1560-7917.ES.2021.26.18.2100423
Loading
Loading full text...

Full text loading...

/deliver/fulltext/eurosurveillance/26/18/eurosurv-26-18-1.html?itemId=/content/10.2807/1560-7917.ES.2021.26.18.2100423&mimeType=html&fmt=ahah

References

  1. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China,2019. N Engl J Med. 2020;382(8):727-33.  https://doi.org/10.1056/NEJMoa2001017  PMID: 31978945 
  2. Cohen JI, Burbelo PD. Reinfections with SARS-CoV-2: Implications for vaccines. Clin Inf Dis. 2020;ciaa1866.  https://doi.org/10.1093/cid/ciaa1866  PMID:33338197
  3. Kellam P, Barclay W. The dynamics of humoral immune responses following SARS-CoV-2 infection and the potential for reinfection. J Gen Virol. 2020;101(8):791-7.  https://doi.org/10.1099/jgv.0.001439  PMID: 32430094 
  4. To KK, Hung IF, Ip JD, Chu AW, Chan WM, Tam AR, et al. COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing. Clin Infect Dis. 2020;ciaa1275. PMID: 32840608 
  5. Larson D, Brodniak SL, Voegtly LJ, Cer RZ, Glang LA, Malagon FJ, et al. A case of early re-infection with SARS-CoV-2. Clin Infect Dis. 2020;ciaa1436. PMID: 32949240 
  6. Tillett RL, Sevinsky JR, Hartley PD, Kerwin H, Crawford N, Gorzalski A, et al. Genomic evidence for reinfection with SARS-CoV-2: a case study. Lancet Infect Dis. 2021;52(1).  https://doi.org/10.1016/S1473-3099(20)30764-7 
  7. European Centre for Disease Prevention and Control (ECDC). Risk related to the spread of new SARS-CoV-2 variants of concern in the EU/EEA – first update. Stockholm: ECDC. 21 Jan 2021. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/COVID-19-risk-related-to-spread-of-new-SARS-CoV-2-variants-EU-EEA-first-update.pdf
  8. Haute Autorité de Santé (HAS). COVID-19 : quelle stratégie de vaccination face aux variants du SARS-CoV-2? [COVID-19: which vaccination strategy for SARS-Cov-2 variants?]. Saint-Denis: HAS. 9 Apr 2021. Press release. French. Available from: https://www.has-sante.fr/jcms/p_3260338/fr/covid-19-quelle-strategie-de-vaccination-face-aux-variants-du-sars-cov-2
  9. Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9(4):357-9.  https://doi.org/10.1038/nmeth.1923  PMID: 22388286 
  10. Hadfield J, Megill C, Bell SM, Huddleston J, Potter B, Callender C, et al. Nextstrain: real-time tracking of pathogen evolution. Bioinformatics. 2018;34(23):4121-3.  https://doi.org/10.1093/bioinformatics/bty407  PMID: 29790939 
  11. Sahin U, Muik A, Derhovanessian E, Vogler I, Kranz LM, Vormehr M, et al. COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses. Nature. 2020;586(7830):594-9.  https://doi.org/10.1038/s41586-020-2814-7  PMID: 32998157 
  12. Zucman N, Uhel F, Descamps D, Roux D, Ricard JD. Severe reinfection with South African SARS-CoV-2 variant 501Y.V2: a case report. Clin Infect Dis. 2021;ciab 129  https://doi.org/10.1093/cid/ciab129  PMID:33566076
  13. Huang SW, Wang SF. SARS-CoV-2 entry related viral and host genetic variations: implications on COVID-19 severity, immune escape and infectivity. Int J Mol Sci. 2021;22(6):3060.  https://doi.org/10.3390/ijms22063060  PMID: 33802729 
  14. Madhi SA, Baillie V, Cutland CL, Voysey M, Koen AL, Fairlie L, et al. Efficacy of the chAdOx1 nCoV-19 Covid-19 vaccine against the B.1.351 Variant. N Engl J Med. 2021;NEJMoa2102214.  https://doi.org/10.1056/NEJMoa2102214  PMID: 33725432 
  15. World Health Organization (WHO). Establishment of the WHO International Standard and Reference Panel for anti-SARS-CoV-2 antibody. Geneva: WHO; 18 Nov 2020. Available from: https://www.who.int/publications/m/item/WHO-BS-2020.2403
  16. Rubio-Acero R, Castelletti N, Fingerle V, Olbrich L, Bakuli A, Wölfel R, et al. In search for the SARS-CoV-2 protection correlate: A head-to-head comparison of two quantitative S1 assays in a group of pre-characterized oligo-/asymptomatic patients. medRxiv. 23 Feb 2021.  https://doi.org/10.1101/2021.02.19.21252080 
Submit comment
Close
Comment moderation successfully completed
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error