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Abstract

Data on effectiveness of the BioNTech­/Pfizer COVID-19 vaccine in real-world settings are limited. In a study of 6,423 healthcare workers in Treviso Province, Italy, we estimated that, within the time intervals of 14–21 days from the first and at least 7 days from the second dose, vaccine effectiveness in preventing SARS-CoV-2 infection was 84% (95% confidence interval (CI): 40–96) and 95% (95% CI: 62–99), respectively. These results could support the ongoing vaccination campaigns by providing evidence for targeted communication.

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/content/10.2807/1560-7917.ES.2021.26.17.2100420
2021-04-29
2024-11-24
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2021.26.17.2100420
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References

  1. World Health Organization (WHO). WHO Coronavirus (COVID-19) Dashboard. Geneva: WHO. [Accessed: 27 Apr 2021]. Available from: https://covid19.who.int
  2. Guzzetta G, Riccardo F, Marziano V, Poletti P, Trentini F, Bella A, et al. Impact of a nationwide lockdown on SARS-CoV-2 transmissibility, Italy. Emerg Infect Dis. 2021;27(1):267-70.  https://doi.org/10.3201/eid2701.202114  PMID: 33080168 
  3. Manica M, Guzzetta G, Riccardo F, Valenti A, Poletti P, Marziano V, et al. Impact of tiered restrictions on human activities and the epidemiology of the second wave of COVID-19 in Italy. medRxiv. 2021.01.10.21249532.  https://doi.org/10.1101/2021.01.10.21249532 
  4. Italian Medicines Agency (AIFA). BioNTech/Pfizer vaccine authorised. Answers to frequently asked questions on AIFA’s website. Rome: AIFA. [Accessed: 27 Apr 2021]. Available from: https://www.aifa.gov.it/en/-/autorizzato-il-vaccino-biontech-pfizer
  5. Polack FP, Thomas SJ, Kitchin N, Absalon J, Gurtman A, Lockhart S, et al. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 2020;383(27):2603-15.  https://doi.org/10.1056/NEJMoa2034577  PMID: 33301246 
  6. Public Health England (PHE). Annex A: Report to JCVI on estimated efficacy of a single dose of Pfizer BioNTech (BNT162b2 mRNA) vaccine and of a single dose of ChAdOx1 vaccine (AZD1222). London: PHE. [Accessed: 27 Apr 2021]. Available from: https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/949505/annex-a-phe-report-to-jcvi-on-estimated-efficacy-of-single-vaccine-dose.pdf
  7. Italian National Institute of Health (ISS). Epidemia COVID-19 – Aggiornamento Nazionale 17 Marzo 2021. [COVID-19 Epidemic - National update]. Rome: ISS.; 2021. Italian. Available from: https://www.epicentro.iss.it/coronavirus/bollettino/Bollettino-sorveglianza-integrata-COVID-19_17-marzo-2021.pdf
  8. Hall VJ, Foulkes S, Saei A, Andrews N, Oguti B, Charlett A, et al. COVID-19 vaccine coverage in health-care workers in England and effectiveness of BNT162b2 mRNA vaccine against infection (SIREN): a prospective, multicentre, cohort study. Lancet. 2021;S0140-6736(21)00790-X. PMID: 33901423 
  9. Amit S, Regev-Yochay G, Afek A, Kreiss Y, Leshem E. Early rate reductions of SARS-CoV-2 infection and COVID-19 in BNT162b2 vaccine recipients. Lancet. 2021;397(10277):875-7.  https://doi.org/10.1016/S0140-6736(21)00448-7  PMID: 33610193 
  10. Schultz LR, Peterson EL, Breslau N. Graphing survival curve estimates for time-dependent covariates. Int J Methods Psychiatr Res. 2002;11(2):68-74.  https://doi.org/10.1002/mpr.124  PMID: 12459796 
  11. Italian Ministry of Health. Covid-19, the new Ministerial Decree (Dpcm) by the Government. Rome: Ministero della Salute. [Accessed: 27 Apr 2021]. Available from: http://www.salute.gov.it/portale/nuovocoronavirus/dettaglioNotizieNuovoCoronavirus.jsp?lingua=english&menu=notizie&p=dalministero&id=5360
Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Massimo+Fabiani&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Fabiani Massimo</a>, <a href="/search?value1=Mauro+Ramigni&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ramigni Mauro</a>, <a href="/search?value1=Valentina+Gobbetto&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gobbetto Valentina</a>, <a href="/search?value1=Alberto+Mateo-Urdiales&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Mateo-Urdiales Alberto</a>, <a href="/search?value1=Patrizio+Pezzotti&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Pezzotti Patrizio</a>, <a href="/search?value1=Cinzia+Piovesan&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Piovesan Cinzia</a></span>. Effectiveness of the Comirnaty (BNT162b2, BioNTech/Pfizer) vaccine in preventing SARS-CoV-2 infection among healthcare workers, Treviso province, Veneto region, Italy, 27 December 2020 to 24 March 2021. <a href="/content/ecdc">Euro Surveill.</a> 2021;26(17):pii=2100420. <a href="https://doi.org/10.2807/1560-7917.ES.2021.26.17.2100420" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2021.26.17.2100420</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 16 Apr 2021;&nbsp;&nbsp; <span class="generated">Accepted</span>: 29 Apr 2021 </span> </p>
/content/10.2807/1560-7917.ES.2021.26.17.2100420
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