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Abstract

Three months after a coronavirus disease (COVID-19) outbreak in Kupferzell, Germany, a population-based study (n = 2,203) found no RT-PCR-positives. IgG-ELISA seropositivity with positive virus neutralisation tests was 7.7% (95% confidence interval (CI): 6.5–9.1) and 4.3% with negative neutralisation tests. We estimate 12.0% (95% CI: 10.4–14.0%) infected adults (24.5% asymptomatic), six times more than notified. Full hotspot containment confirms the effectiveness of prompt protection measures. However, 88% naïve adults are still at high COVID-19 risk.

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/content/10.2807/1560-7917.ES.2020.25.47.2001752
2020-11-26
2024-11-05
http://instance.metastore.ingenta.com/content/10.2807/1560-7917.ES.2020.25.47.2001752
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Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020
<p class="citation"> <span>Citation style for this article:</span> <span class="meta-value authors"> <a href="/search?value1=Claudia+Santos-H%C3%B6vener&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Santos-Hövener Claudia</a>, <a href="/search?value1=Hannelore+K+Neuhauser&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Neuhauser Hannelore K</a>, <a href="/search?value1=Angelika+Schaffrath+Rosario&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Rosario Angelika Schaffrath</a>, <a href="/search?value1=Markus+Busch&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Busch Markus</a>, <a href="/search?value1=Martin+Schlaud&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schlaud Martin</a>, <a href="/search?value1=Robert+Hoffmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoffmann Robert</a>, <a href="/search?value1=Antje+G%C3%B6%C3%9Fwald&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Gößwald Antje</a>, <a href="/search?value1=Carmen+Koschollek&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Koschollek Carmen</a>, <a href="/search?value1=Jens+Hoebel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hoebel Jens</a>, <a href="/search?value1=Jennifer+Allen&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Allen Jennifer</a>, <a href="/search?value1=Antje+Haack-Erdmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Haack-Erdmann Antje</a>, <a href="/search?value1=Stefan+Brockmann&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Brockmann Stefan</a>, <a href="/search?value1=Thomas+Ziese&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Ziese Thomas</a>, <a href="/search?value1=Andreas+Nitsche&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Nitsche Andreas</a>, <a href="/search?value1=Janine+Michel&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Michel Janine</a>, <a href="/search?value1=Sebastian+Haller&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Haller Sebastian</a>, <a href="/search?value1=Hendrik+Wilking&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wilking Hendrik</a>, <a href="/search?value1=Osamah+Hamouda&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Hamouda Osamah</a>, <a href="/search?value1=Victor+M+Corman&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Corman Victor M</a>, <a href="/search?value1=Christian+Drosten&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Drosten Christian</a>, <a href="/search?value1=Lars+Schaade&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Schaade Lars</a>, <a href="/search?value1=Lothar+H+Wieler&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Wieler Lothar H</a>, <a href="/search?value1=CoMoLo+Study+Group&option1=author&noRedirect=true" class="nonDisambigAuthorLink">CoMoLo Study Group</a>, <a href="/search?value1=Thomas+Lampert&option1=author&noRedirect=true" class="nonDisambigAuthorLink">Lampert Thomas</a></span>. Serology- and PCR-based cumulative incidence of SARS-CoV-2 infection in adults in a successfully contained early hotspot (CoMoLo study), Germany, May to June 2020. <a href="/content/ecdc">Euro Surveill.</a> 2020;25(47):pii=2001752. <a href="https://doi.org/10.2807/1560-7917.ES.2020.25.47.2001752" title="doi link" target="_blank">https://doi.org/10.2807/1560-7917.ES.2020.25.47.2001752</a> <span class="ES_Article_citation"> <span class="generated">Received</span>: 06 Oct 2020;&nbsp;&nbsp; <span class="generated">Accepted</span>: 25 Nov 2020 </span> </p>
/content/10.2807/1560-7917.ES.2020.25.47.2001752
/content/10.2807/1560-7917.ES.2020.25.47.2001752
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